Search Results - "Wesselink, Thomas H."

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8 + T Cells in the Lungs by Behr, Felix M, Kragten, Natasja A M, Wesselink, Thomas H, Nota, Benjamin, van Lier, Rene A W, Amsen, Derk, Stark, Regina, Hombrink, Pleun, van Gisbergen, Klaas P J M

“…Tissue-resident memory CD8 T (T ) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection…”
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Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment by van der Gracht, Esmé T.I., Beyrend, Guillaume, Abdelaal, Tamim, Pardieck, Iris N., Wesselink, Thomas H., van Haften, Floortje J., van Duikeren, Suzanne, Koning, Frits, Arens, Ramon

“…Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell…”
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Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses by Behr, Felix M., Parga-Vidal, Loreto, Kragten, Natasja A. M., van Dam, Teunis J. P., Wesselink, Thomas H., Sheridan, Brian S., Arens, Ramon, van Lier, Rene A. W., Stark, Regina, van Gisbergen, Klaas P. J. M.

“…Tissue-resident memory CD8 + T cells (T RM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue…”
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Circulating memory CD8+ T cells are limited in forming CD103+ tissue‐resident memory T cells at mucosal sites after reinfection by Behr, Felix M., Beumer‐Chuwonpad, Ammarina, Kragten, Natasja A. M., Wesselink, Thomas H., Stark, Regina, Gisbergen, Klaas P. J. M.

“…Tissue‐resident memory CD8+ T cells (TRM) localize to barrier tissues and mediate local protection against reinvading pathogens. Circulating central memory…”
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Blimp‐1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells by Kragten, Natasja A.M., Behr, Felix M., Vieira Braga, Felipe A., Remmerswaal, Ester B. M., Wesselink, Thomas H., Oja, Anna E., Hombrink, Pleun, Kallies, Axel, Lier, Rene A.W., Stark, Regina, Gisbergen, Klaas P.J.M.

“…CD8 T cells acquire cytotoxic molecules including granzyme B during effector differentiation. Both tissue‐resident memory CD8 T cells (Trm) and circulating…”
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Murine iNKT cells are depleted by liver damage via activation of P2RX7 by Bovens, Astrid A., Wesselink, Thomas H., Behr, Felix M., Kragten, Natasja A. M., Lier, René A. W., Gisbergen, Klaas P. J. M., Stark, Regina

“…Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to immunosurveillance as well as pathogenesis of the liver…”
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Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes by Parga-Vidal, Loreto, Behr, Felix M, Kragten, Natasja A M, Nota, Benjamin, Wesselink, Thomas H, Kavazović, Inga, Covill, Laura E, Schuller, Margo B P, Bryceson, Yenan T, Wensveen, Felix M, van Lier, Rene A W, van Dam, Teunis J P, Stark, Regina, van Gisbergen, Klaas P J M

“…Tissue-resident memory CD8 T cells (T ) constitute a noncirculating memory T cell subset that provides early protection against reinfection. However, how T…”
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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum by van der Sluis, Tetje C., Beyrend, Guillaume, van der Gracht, Esmé T.I., Abdelaal, Tamim, Jochems, Simon P., Belderbos, Robert A., Wesselink, Thomas H., van Duikeren, Suzanne, van Haften, Floortje J., Redeker, Anke, Ouboter, Laura F., Beyranvand Nejad, Elham, Camps, Marcel, Franken, Kees L.M.C., Linssen, Margot M., Hohenstein, Peter, de Miranda, Noel F.C.C., Mei, Hailiang, Bins, Adriaan D., Haanen, John B.A.G., Aerts, Joachim G., Ossendorp, Ferry, Arens, Ramon

“…Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully…”
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Tissue-resident memory CD8.sup.+ T cells shape local and systemic secondary T cell responses by Behr, Felix M, Parga-Vidal, Loreto, Kragten, Natasja A. M, van Dam, Teunis J. P, Wesselink, Thomas H, Sheridan, Brian S, Arens, Ramon

“…Tissue-resident memory CD8.sup.+ T cells (T.sub.RM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue…”
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