Search Results - "Wesseling, John F"

Emerging roles of GluN3-containing NMDA receptors in the CNS by Pérez-Otaño, Isabel, Larsen, Rylan S., Wesseling, John F.

“…Key Points GluN3 subunits (A and B) were the last members of the glutamate receptor subunit family to be cloned. They assemble with GluN1 and GluN2 (A–D)…”
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Considerations for Measuring Activity-Dependence of Recruitment of Synaptic Vesicles to the Readily Releasable Pool by Wesseling, John F

“…The connection strength of most chemical synapses changes dynamically during normal use as a function of the recent history of activity. The phenomenon is…”
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Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses by Rodriguez Gotor, Juan Jose, Mahfooz, Kashif, Perez-Otano, Isabel, Wesseling, John F

“…Vesicles within presynaptic terminals are thought to be segregated into a variety of readily releasable and reserve pools. The nature of the pools and…”
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Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts by Raja, Mathan K, Preobraschenski, Julia, Del Olmo-Cabrera, Sergio, Martinez-Turrillas, Rebeca, Jahn, Reinhard, Perez-Otano, Isabel, Wesseling, John F

“…Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic…”
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A Well-Defined Readily Releasable Pool with Fixed Capacity for Storing Vesicles at Calyx of Held by Mahfooz, Kashif, Singh, Mahendra, Renden, Robert, Wesseling, John F

“…The readily releasable pool (RRP) of vesicles is a core concept in studies of presynaptic function. However, operating principles lack consensus definition and…”
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Levetiracetam accelerates the onset of supply rate depression in synaptic vesicle trafficking by García‐Pérez, Elizabeth, Mahfooz, Kashif, Covita, João, Zandueta, Aitor, Wesseling, John F.

“…Summary Objective To determine if levetiracetam (LEV) enhances the impact in excitatory presynaptic terminals of a rate‐limiting mechanism in vesicle…”
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GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models by Mahfooz, Kashif, Marco, Sonia, Martínez-Turrillas, Rebeca, Raja, Mathan K, Pérez-Otaño, Isabel, Wesseling, John F

“…Abstract Age-inappropriate expression of juvenile NMDA receptors (NMDARs) containing GluN3A subunits has been linked to synapse loss and death of spiny…”
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Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation by Roberts, Adam C., Díez-García, Javier, Rodriguiz, Ramona M., López, Iciar Paula, Luján, Rafael, Martínez-Turrillas, Rebeca, Picó, Esther, Henson, Maile A., Bernardo, Danilo R., Jarrett, Thomas M., Clendeninn, Dallis J., López-Mascaraque, Laura, Feng, Guoping, Lo, Donald C., Wesseling, John F., Wetsel, William C., Philpot, Benjamin D., Pérez-Otaño, Isabel

“…NR3A is the only NMDA receptor (NMDAR) subunit that downregulates sharply prior to the onset of sensitive periods for plasticity, yet the functional importance…”
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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly by Conde-Dusman, María J, Dey, Partha N, Elía-Zudaire, Óscar, Rabaneda, Luis G, García-Lira, Carmen, Grand, Teddy, Briz, Victor, Velasco, Eric R, Andero, Raül, Niñerola, Sergio, Barco, Angel, Paoletti, Pierre, Wesseling, John F, Gardoni, Fabrizio, Tavalin, Steven J, Perez-Otaño, Isabel

“…De novo protein synthesis is required for synapse modifications underlying stable memory encoding. Yet neurons are highly compartmentalized cells and how…”
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Editorial: Methods for Synaptic Interrogation by Feldmeyer, Dirk, Wesseling, John F., Sjöström, P. Jesper

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Activity-Dependent Modulation of the Rate at which Synaptic Vesicles Become Available to Undergo Exocytosis by Stevens, Charles F, Wesseling, John F

“…The number of vesicles contained in the readily releasable pool at excitatory hippocampal synapses has recently been identified as a major determinant of the…”
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Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles by Park, Daehun, Fujise, Kenshiro, Wu, Yumei, Luján, Rafael, Del Olmo-Cabrera, Sergio, Wesseling, John F, De Camilli, Pietro

“…Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV)…”
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Limit on the Role of Activity in Controlling the Release-Ready Supply of Synaptic Vesicles by Wesseling, John F, Lo, Donald C

“…Typical fast chemical synapses in the brain weaken transiently during normal high-frequency use after expending their presynaptic supply of release-ready…”
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Modulation of GluN3A expression in Huntington disease: a new n-methyl-D-aspartate receptor-based therapeutic approach? by Wesseling, John F, Pérez-Otaño, Isabel

“…Huntington disease (HD) is an inherited neurodegenerative disorder with no cure or effective palliative treatment. An ideal therapy would arrest pathogenesis…”
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Augmentation Is a Potentiation of the Exocytotic Process by Stevens, Charles F, Wesseling, John F

“…Short-term synaptic enhancement is caused by an increase in the probability with which synaptic terminals release transmitter in response to presynaptic action…”
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Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models by Marco, Sonia, Giralt, Albert, Petrovic, Milos M, Pouladi, Mahmoud A, Martínez-Turrillas, Rebeca, Martínez-Hernández, José, Kaltenbach, Linda S, Torres-Peraza, Jesús, Graham, Rona K, Watanabe, Masahiko, Luján, Rafael, Nakanishi, Nobuki, Lipton, Stuart A, Lo, Donald C, Hayden, Michael R, Alberch, Jordi, Wesseling, John F, Pérez-Otaño, Isabel

“…Huntington's disease is a neurodegenerative disorder associated with glutamate receptor dysfunction. Now Isabel Pérez-Otaño and colleagues report that the HTT…”
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Sparse force-bearing bridges between neighboring synaptic vesicles by Wesseling, John F., Phan, Sébastien, Bushong, Eric A., Siksou, Léa, Marty, Serge, Pérez-Otaño, Isabel, Ellisman, Mark

“…Most vesicles in the interior of synaptic terminals are clustered in clouds close to active zone regions of the plasma membrane where exocytosis occurs…”
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Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors by Chowdhury, Dhrubajyoti, Marco, Sonia, Brooks, Ian M, Zandueta, Aitor, Rao, Yijian, Haucke, Volker, Wesseling, John F, Tavalin, Steven J, Pérez-Otaño, Isabel

“…Selective control of receptor trafficking provides a mechanism for remodeling the receptor composition of excitatory synapses, and thus supports synaptic…”
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Augmentation Controls the Fast Rebound From Depression at Excitatory Hippocampal Synapses by Garcia-Perez, Elizabeth, Wesseling, John F

“…Departamento de Neurociencias, Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona, Spain Submitted 14 December 2007; accepted in final…”
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A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs by Gabriel, Thomas, García-Pérez, Elizabeth, Mahfooz, Kashif, Goñi, Joaquín, Martínez-Turrillas, Rebeca, Pérez-Otaño, Isabel, Lo, Donald C, Wesseling, John F

“…At least two rate-limiting mechanisms in vesicle trafficking operate at mouse Schaffer collateral synapses, but their molecular/physical identities are…”
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