Search Results - "Wesoowska, Anna"

The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration by Nikiforuk, Agnieszka, Kos, Tomasz, Wesołowska, Anna

“…Rationale Preclinical data suggest a possible role for 5-HT6 receptors in depression and anxiety. However, the results of pharmacological studies are equivocal…”
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Antipsychotic, antidepressant, and cognitive-impairment properties of antipsychotics: rat profile and implications for behavioral and psychological symptoms of dementia by Kołaczkowski, Marcin, Mierzejewski, Paweł, Bienkowski, Przemyslaw, Wesołowska, Anna, Newman-Tancredi, Adrian

“…Many dementia patients exhibit behavioral and psychological symptoms (BPSD), including psychosis and depression. Although antipsychotics are frequently…”
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Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties by Canale, Vittorio, Kurczab, Rafał, Partyka, Anna, Satała, Grzegorz, Lenda, Tomasz, Jastrzębska-Więsek, Magdalena, Wesołowska, Anna, Bojarski, Andrzej J., Zajdel, Paweł

“…A series of 39 arylsulfonamide/amide derivatives of (aryloxy)ethyl alkyl amines, was designed with the support of the Virtual Combinatorial Library-Virtual…”
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ADN-1184, a monoaminergic ligand with 5-HT^sub 6/7^ receptor antagonist action, exhibits activity in animal models of anxiety by Partyka, Anna, Wasik, Anna, Jastrzbska-wisek, Magdalena, Mierzejewski, Pawe, Biekowski, Przemysaw, Koaczkowski, Marcin, Wesoowska, Anna

“…Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood…”
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Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT sub(6) partial agonist in rats by Jastrzbska-Wisek, Magdalena, Siwek, Agata, Partyka, Anna, Antkiewicz-Michaluk, Lucyna, Michaluk, Jerzy, Romaska, Irena, Koaczkowski, Marcin, Wesoowska, Anna

“…It was shown that 5-HT sub(6) receptor agonists can exert pharmacological activity due to various modifications in monoamines' level and metabolism activity in…”
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Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT^sub 6^ partial agonist in rats by Jastrzbska-wisek, Magdalena, Siwek, Agata, Partyka, Anna, Antkiewicz-michaluk, Lucyna, Michaluk, Jerzy, Romaska, Irena, Koaczkowski, Marcin, Wesoowska, Anna

“…It was shown that 5-HT6 receptor agonists can exert pharmacological activity due to various modifications in monoamines' level and metabolism activity in rats'…”
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Antidepressant-like activity of EMD 386088, a 5-HT^sub 6^ receptor partial agonist, following systemic acute and chronic administration to rats by Jastrzbska-wisek, Magdalena, Siwek, Agata, Partyka, Anna, Szewczyk, Bernadeta, Sowa-kucma, Magdalena, Wasik, Anna, Koaczkowski, Marcin, Wesoowska, Anna

“…The study was designed to examine the potency of EMD 386088, a 5-HT^sub 6^ receptor partial agonist, to exert antidepressant-like properties in animal models…”
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Antidepressant-like activity of EMD 386088, a 5-HT sub(6) receptor partial agonist, following systemic acute and chronic administration to rats by Jastrzbska-Wisek, Magdalena, Siwek, Agata, Partyka, Anna, Szewczyk, Bernadeta, Sowa-Kucma, Magdalena, Wasik, Anna, Koaczkowski, Marcin, Wesoowska, Anna

“…The study was designed to examine the potency of EMD 386088, a 5-HT sub(6) receptor partial agonist, to exert antidepressant-like properties in animal models…”
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Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders by Partyka, Anna, Jarosz, Jakub, Wasik, Anna, Jastrzębska-Więsek, Magdalena, Zagórska, Agnieszka, Pawłowski, Maciej, Wesołowska, Anna

“…Objectives The purpose of this study was to investigate the central activity of the two new imidazo[2,1‐f]purine‐2,4‐dione derivatives behaved as presynaptic…”
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Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A/5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity by Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Partyka, Anna, Wesołowska, Anna, Kazek, Grzegorz, Głuch-Lutwin, Monika, Siwek, Agata, Starowicz, Gabriela, Pawłowski, Maciej

“…In the search for potential psychotropic agents, a new series of 3,7‐dimethyl‐ and 1,3‐dimethyl‐8‐alkoxypurine‐2,6‐dione derivatives of arylpiperazines,…”
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Novel Mannich Bases, 5-Arylimidazolidine-2,4-dione Derivatives with Dual 5-HT1A Receptor and Serotonin Transporter Affinity by Czopek, Anna, Kołaczkowski, Marcin, Bucki, Adam, Byrtus, Hanna, Pawłowski, Maciej, Siwek, Agata, Bojarski, Andrzej J., Bednarski, Marek, Wróbel, Dagmara, Wesołowska, Anna

“…A computer aided ligand design study of imidazolidine‐2,4‐dione derivatives was conducted in order to obtain compounds with dual 5‐HT1A receptor and serotonin…”
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Structure-5-HT/D2 Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione by Żmudzki, Paweł, Satała, Grzegorz, Chłoń-Rzepa, Grażyna, Bojarski, Andrzej J., Kazek, Grzegorz, Siwek, Agata, Gryboś, Anna, Głuch-Lutwin, Monika, Wesołowska, Anna, Pawłowski, Maciej

“…In our previous papers, we have reported that some 8‐amino‐1,3‐dimethyl‐1H‐purine‐2,6(3H,7H)‐dione derivatives possessed high affinity and displayed agonistic,…”
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Synthesis and Pharmacological Evaluation of Novel Tricyclic[2,1-f]theophylline Derivatives by Zagórska, Agnieszka, Pawłowski, Maciej, Siwek, Agata, Kazek, Grzegorz, Partyka, Anna, Wróbel, Dagmara, Jastrzębska-Więsek, Magdalena, Wesołowska, Anna

“…The multireceptor strategy was implemented to obtain potential antipsychotics and/or antidepressants in a series of long‐chain arylpiperazines bearing a…”
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New Arylpiperazinylalkyl Derivatives of 8-Alkoxy-purine-2,6-dione and Dihydro[1,3]oxazolo[2,3-f]purinedione Targeting the Serotonin 5-HT1A/5-HT2A/5-HT7 and Dopamine D2 Receptors by Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Bucki, Adam, Kołaczkowski, Marcin, Pawłowski, Maciej, Satała, Grzegorz, Bojarski, Andrzej J., Partyka, Anna, Wesołowska, Anna, Pękala, Elżbieta, Słoczyńska, Karolina

“…To obtain potential antidepressants and/or antipsychotics, a series of new long‐chain arylpiperazine derivatives of 8‐alkoxy‐purine‐2,6‐dione (10–24) and…”
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MD-354 selectively antagonizes the antinociceptive effects of (−)nicotine in the mouse tail-flick assay by Dukat, Małgorzata, Wesołowska, Anna, Alley, Genevieve, Young, Shawquia, Abdrakhmanova, Galya R., Navarro, Hernán A., Young, Richard, Glennon, Richard A.

“…Rationale (−)Nicotine produces antinociceptive effects in rodents. meta -Chlorophenylguanidine (MD-354), an analgesia-enhancing agent, binds at 5-HT 3 and α 2…”
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