Search Results - "Wesolowska, O"

Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal by Michalak, K, Wesolowska, O, Motohashi, N, Molnar, J, Hendrich, A B

“…The mechanism of multidrug resistance (MDR) reversal is not fully understood yet. Interaction of MDR modifiers with lipid bilayer of cell membranes and…”
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Benzo[a]phenoxazines: A New Group of Potent P-glycoprotein Inhibitors by Wesolowska, Olga, Molnar, Joseph, Westman, Gunnar, Samuelsson, Kristin, Kawase, Masami, Ocsovszki, Imre, Motohashi, Noboru, Michalak, Krystyna

“…The ability of fifteen novel phenoxazine derivatives (four phenoxazines and eleven benzo[a]phenoxazines) to modulate multidrug resistance (MDR) in a…”
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Human Sarcoma Cell Lines MES-SA and MES-SA/Dx5 as a Model for Multidrug Resistance Modulators Screening by WESOLOWSKA, Olga, PAPROCKA, Maria, KOZLAK, Joanna, MOTOHASHI, Noboru, DUS, Danuta, MICHALAK, Krystyna

“…The choice of cell lines for multidrug resistance (MDR) modulators screening may affect the results obtained. Screening is most often performed in model…”
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Trifluoperazine induces domain formation in zwitterionic phosphatidylcholine but not in charged phosphatidylglycerol bilayers by Hendrich, A B, Wesolowska, O, Michalak, K

“…The interaction of trifluoperazine with the zwitterionic lipids dipalmitoylphosphatidylcholine and dimyristoylphosphatidylcholine and with anionic…”
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Phenothiazine maleates stimulate MRP1 transport activity in human erythrocytes by Wesołowska, Olga, Mosiądz, Daniela, Motohashi, Noboru, Kawase, Masami, Michalak, Krystyna

“…The expression of multidrug resistance-associated protein (MRP1) results in ATP-dependent reduction of drugs' concentration in cancer cells, i.e., multidrug…”
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New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency by Hendrich, Andrzej B., Wesołowska, Olga, Motohashi, Noboru, Molnár, Joseph, Michalak, Krystyna

“…The phenothiazine multidrug resistance (MDR) modulators are chemically diversified but share the common feature to be hydrophobic cationic molecules. Molecular…”
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ANTICANCER PROPERTIES AND MULTIDRUG RESISTANCE MODULATORY EFFECT OF PLANT POLYPHENOLS AND THEIR INTERACTION WITH MEMBRANE COMPONENTS by Michalak, K, Wesolowska, O, Wisniewski, J, Sroda, K, Teisseyre, A, Kuzdzal, M, Strancar, J, Duarte, N, Ferreira, M-JU

“…Many compounds of plant origin were formed to be interesting for potential application in cancer prevention or chemotherapy. Such agents were found among…”
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ANTICANCER PROPERITES AND MDR MODULATORY EFFECT OF PLANT POLYPHENOLS AND THEIR INTERACTION WITH MEMBRANE COMPONENTS by Michalak, K, Wesolowska, O, Wisniewski, J, Sroda, K, Teisseyre, A, Kuzdzal, M, Strancar, J, Duarte, N, Ferreira, M-JU

“…Many compounds of plant origin have been identified to be interesting for potential application in cancer prevention or chemotherapy. Such agents were found…”
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Inhibition of P-glycoprotein transport function by N-acylphenothiazines by Wesolowska, Olga, Molnár, Joseph, Motohashi, Noboru, Michalak, Krystyna

“…Multidrug resistance (mdr) constitutes the major obstacle to successful cancer treatment. The ability of fifteen newly-synthesised N-acylphenothiazine…”
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The alterations of lipid bilayer fluidity induced by newly synthesized phenothiazine derivative by Hendrich, Andrzej B., Wesołowska, Olga, Komorowska, Małgorzata, Motohashi, Noboru, Michalak, Krystyna

“…Using fluorescence spectroscopy, calorimetry and ESR the interactions of the phenothiazine derivative…”
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Presence of anionic phospholipids rules the membrane localization of phenothiazine type multidrug resistance modulator by Wesołowska, Olga, Hendrich, Andrzej B., Motohashi, Noboru, Kawase, Masami, Dobryszycki, Piotr, Ożyhar, Andrzej, Michalak, Krystyna

“…Substances able to modulate multidrug resistance (MDR), including antipsychotic phenothiazine derivatives, are mainly cationic amphiphiles. The molecular…”
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Phage display of proteins by Kościelska, K, Kiczak, L, Kasztura, M, Wesołowska, O, Otlewski, J

“…In recent years the phage display approach has become an increasingly popular method in protein research. This method enables the presentation of large peptide…”
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Enhancement of chymotrypsin-inhibitor/substrate interactions by 3 M NaCl by Wesołowska, O, Krokoszyńska, I, Krowarsch, D, Otlewski, J

“…A series of 16 bovine pancreatic trypsin inhibitor variants mutated at the P(1) position of the binding loop and seven tetrapeptide p-nitroanilide (pNa)…”
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Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity by Hendrich, Andrzej B, Wesołowska, Olga, Poła, Andrzej, Motohashi, Noboru, Molnár, Joseph, Michalak, Kystyna

“…Although phenothiazines are known as multidrug resistance modifiers, the molecular mechanism of their activity remains unclear. Since phenothiazine molecules…”
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A new phenothiazine derivative alters the fluidity and thermotropic behaviour of phosphatidylcholine model membranes by Wesołowska, Olga, Hendrich, Andrzej B, Motohashi, Noboru, Michalak, Krystyna

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Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance by Michalak, Krystyna, Hendrich, Andrzej B, Wesołowska, Olga, Poła, Andrzej, Łania-Pietrzak, Barbara, Motohashi, Noboru, Shirataki, Yoshiaki, Molnar, Joseph

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Reversal of multidrug resitance by natural substances from plants by Molnár, J, Engi, H, Hohmann, J, Molnár, P, Deli, J, Wesolowska, O, Michalak, K, Wang, Q

“…The multidrug resistance (MDR) proteins that belong to the ATP-binding cassette superfamily such as P-glycoprotein (P-gp) and MRP1, are present in a majority…”
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Antimicrobial Activity of N-Acylphenothiazines and Their Influence on Lipid Model Membranes and Erythrocyte Membranes by Motohashi, Noboru, Kawase, Masami, Molnár, Joseph, Ferenczy, Lajos, Wesolowska, Olga, Hendrich, Andrzej B., Bobrowska-Hägerstrand, Malgorzata, Hägerstrand, Henry, Michalak, Krystyna

“…Summary The antibacterial activity and influence on lipid model membranes and erythrocyte membranes of 24 N-acylphenothiazines and trifluoperazine were…”
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