Search Results - "Wesemann, Duane"

Omicron’s message on vaccines: Boosting begets breadth by Wesemann, Duane R.

“…In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense—neutralizing antibodies. However, while one- or…”
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The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease by Wesemann, Duane R., Nagler, Cathryn R.

“…Allergic disease affects millions. Despite many advances in our understanding of the immune system in the past century, the physiologic underpinning for the…”
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Antibody repertoire and autoimmunity by Skevaki, Chrysanthi, Wesemann, Duane R.

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Analyzing Immunoglobulin Repertoires by Chaudhary, Neha, Wesemann, Duane R

“…Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast diversity of lymphocyte antigen recognition capacity. The advent of…”
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Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant by Zhang, Jun, Xiao, Tianshu, Cai, Yongfei, Lavine, Christy L, Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Mayer, Megan L, Walsh, Jr, Richard M, Rits-Volloch, Sophia, Wesemann, Duane R, Yang, Wei, Seaman, Michael S, Lu, Jianming, Chen, Bing

“…The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain…”
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Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants by Cai, Yongfei, Zhang, Jun, Xiao, Tianshu, Lavine, Christy L, Rawson, Shaun, Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Lu, Shen, Sterling, Sarah M, Walsh, Jr, Richard M, Rits-Volloch, Sophia, Lu, Jianming, Wesemann, Duane R, Yang, Wei, Seaman, Michael S, Chen, Bing

“…Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19…”
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Whence and wherefore IgE? by Rahman, Rifat S, Wesemann, Duane R

“…Despite the near ubiquitous presence of Ig-based antibodies in vertebrates, IgE is unique to mammals. How and why it emerged remains mysterious. IgE expression…”
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Antibody Dynamics and Durability in Coronavirus Disease-19 by Zuiani, Adam, Wesemann, Duane R.

“…Severe acute respiratory syndrome coronavirus 2 (COVID)-19 has emerged as the greatest global health threat in generations. An unprecedented mobilization of…”
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Affinity war: forging immunoglobulin repertoires by Zuo, Teng, Gautam, Avneesh, Wesemann, Duane R

“…[Display omitted] •Ig tolerance checkpoints themselves may be subject to regulation.•Microbial symbionts influence naïve and experienced Ig repertoires.•Early…”
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Structural and functional impact by SARS-CoV-2 Omicron spike mutations by Zhang, Jun, Cai, Yongfei, Lavine, Christy L., Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Mayer, Megan L., Rits-Volloch, Sophia, Wang, Shaowei, Sliz, Piotr, Wesemann, Duane R., Yang, Wei, Seaman, Michael S., Lu, Jianming, Xiao, Tianshu, Chen, Bing

“…The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bearing an unusually high number of mutations, has become a dominant…”
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Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women by Gosmann, Christina, Anahtar, Melis N., Handley, Scott A., Farcasanu, Mara, Abu-Ali, Galeb, Bowman, Brittany A., Padavattan, Nikita, Desai, Chandni, Droit, Lindsay, Moodley, Amber, Dong, Mary, Chen, Yuezhou, Ismail, Nasreen, Ndung’u, Thumbi, Ghebremichael, Musie S., Wesemann, Duane R., Mitchell, Caroline, Dong, Krista L., Huttenhower, Curtis, Walker, Bruce D., Virgin, Herbert W., Kwon, Douglas S.

“…Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their…”
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Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production by Chen, Yuezhou, Zuiani, Adam, Fischinger, Stephanie, Mullur, Jyotsna, Atyeo, Caroline, Travers, Meghan, Lelis, Felipe J.N., Pullen, Krista M., Martin, Hannah, Tong, Pei, Gautam, Avneesh, Habibi, Shaghayegh, Bensko, Jillian, Gakpo, Deborah, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Cai, Yongfei, Burke, John S., Lin, Junrui, Lederer, James A., Lam, Evan Christopher, Lavine, Christy L., Seaman, Michael S., Chen, Bing, Schmidt, Aaron G., Balazs, Alejandro Benjamin, Lauffenburger, Douglas A., Alter, Galit, Wesemann, Duane R.

“…Antibodies are key immune effectors that confer protection against pathogenic threats. The nature and longevity of the antibody response to SARS-CoV-2…”
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Microbes and B cell development by Wesemann, Duane R

“…Animals and many of their chronic microbial inhabitants form relationships of symbiotic mutualism, which occurs when coexisting life-forms derive mutual…”
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Rituximab Monotherapy for Common Variable Immune Deficiency-Associated Granulomatous-Lymphocytic Interstitial Lung Disease by Ng, Julie, Wright, Kyle, Alvarez, Maura, Hunninghake, Gary M., Wesemann, Duane R.

“…Patients with common variable immunodeficiency (CVID) can develop granulomatous-lymphocytic interstitial lung disease (GLILD), which is associated with…”
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Microbial colonization influences early B-lineage development in the gut lamina propria by Wesemann, Duane R., Portuguese, Andrew J., Meyers, Robin M., Gallagher, Michael P., Cluff-Jones, Kendra, Magee, Jennifer M., Panchakshari, Rohit A., Rodig, Scott J., Kepler, Thomas B., Alt, Frederick W.

“…Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it…”
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53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions by Callen, Elsa, Di Virgilio, Michela, Kruhlak, Michael J., Nieto-Soler, Maria, Wong, Nancy, Chen, Hua-Tang, Faryabi, Robert B., Polato, Federica, Santos, Margarida, Starnes, Linda M., Wesemann, Duane R., Lee, Ji-Eun, Tubbs, Anthony, Sleckman, Barry P., Daniel, Jeremy A., Ge, Kai, Alt, Frederick W., Fernandez-Capetillo, Oscar, Nussenzweig, Michel C., Nussenzweig, André

“…The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as…”
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SARS-CoV-2-specific ELISA development by Roy, Vicky, Fischinger, Stephanie, Atyeo, Caroline, Slein, Matthew, Loos, Carolin, Balazs, Alejandro, Luedemann, Corinne, Astudillo, Michael Gerino, Yang, Diane, Wesemann, Duane R., Charles, Richelle, Lafrate, A. John, Feldman, Jared, Hauser, Blake, Caradonna, Tim, Miller, Tyler E., Murali, Mandakolathur R., Baden, Lindsey, Nilles, Eric, Ryan, Edward, Lauffenburger, Douglas, Beltran, Wilfredo Garcia, Alter, Galit

“…Critical to managing the spread of COVID-19 is the ability to diagnose infection and define the acquired immune response across the population. While genomic…”
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Primary immunoglobulin repertoire development: time and space matter by Granato, Alessandra, Chen, Yuezhou, Wesemann, Duane R

“…Highlights • V(D)J recombination drives the generation of the primary immunoglobulin repertoire. • Selection forces define limits to emerging immunoglobulin…”
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Origins of peanut allergy-causing antibodies by Wesemann, Duane R, Nagler, Cathryn R

“…Analysis of gut-produced antibodies raises questions about how food allergy arises Some people produce immunoglobulin E (IgE) antibodies to proteins in common…”
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Microbial symbionts regulate the primary Ig repertoire by Chen, Yuezhou, Chaudhary, Neha, Yang, Nicole, Granato, Alessandra, Turner, Jacob A, Howard, Shannon L, Devereaux, Colby, Zuo, Teng, Shrestha, Akritee, Goel, Rishi R, Neuberg, Donna, Wesemann, Duane R

“…The ability of immunoglobulin (Ig) to recognize pathogens is critical for optimal immune fitness. Early events that shape preimmune Ig repertoires, expressed…”
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