Search Results - "Wesche, Doreen E."

Leukocyte apoptosis and its significance in sepsis and shock by Wesche, Doreen E., Lomas‐Neira, Joanne L., Perl, Mario, Chung, Chun‐Shiang, Ayala, Alfred

“…Sepsis and multiple organ failure continue to be significant problems among trauma, burn, and the critically ill patient population. Thus, a number of…”
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In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury by Lomas‐Neira, Joanne L., Chung, Chun‐Shiang, Wesche, Doreen E., Perl, Mario, Ayala, Alfred

“…Lung injury in trauma patients exposed to a secondary infectious/septic challenge contributes to the high morbidity/mortality observed in this population…”
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In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice by Wesche-Soldato, Doreen E., Chung, Chun-Shiang, Lomas-Neira, Joanne, Doughty, Lesley A., Gregory, Stephen H., Ayala, Alfred

“…Although studies have shown increased evidence of death receptor-driven apoptosis in intestinal lymphoid cells, splenocytes, and the liver following the onset…”
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The apoptotic pathway as a therapeutic target in sepsis by Wesche-Soldato, Doreen E, Swan, Ryan Z, Chung, Chun-Shiang, Ayala, Alfred

“…Recent research has yielded many interesting and potentially important therapeutic targets in sepsis. Specifically, the effects of antagonistic anti-cytokine…”
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Macrophage arginase regulation by CCAAT/enhancer-binding protein β by ALBINA, Jorge E, MAHONEY, Eric J, DALEY, Jean M, WESCHE, Doreen E, MORRIS, Sidney M, REICHNER, Jonathan S

“…Arginase activity is expressed by macrophages in healing wounds and other sites of inflammation and has been shown to modulate the synthesis of nitric oxide,…”
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CD8+ T Cells Promote Inflammation and Apoptosis in the Liver after Sepsis: Role of Fas-FasL by Wesche-Soldato, Doreen E, Chung, Chun-Shiang, Gregory, Stephen H, Salazar-Mather, Thais P, Ayala, Carol A, Ayala, Alfred

“…Although studies blocking the Fas pathway indicate it can decrease organ damage while improving septic (cecal ligation and puncture, CLP) mouse survival,…”
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Hydrodynamic delivery of siRNA in a mouse model of sepsis by Wesche-Soldato, Doreen E, Lomas-Neira, Joanne, Perl, Mario, Chung, Chun-Shiang, Ayala, Alfred

“…The use of siRNA in vivo as well as in animal models has become more widespread in recent years, leading to further questions as to the best mode of delivery…”
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CD8+ T Cells Promote Inflammation and Apoptosis in the Liver after Sepsis by Wesche-Soldato, Doreen E, Chung, Chun-Shiang, Gregory, Stephen H, Salazar-Mather, Thais P, Ayala, Carol A, Ayala, Alfred

“…Although studies blocking the Fas pathway indicate it can decrease organ damage while improving septic (cecal ligation and puncture, CLP) mouse survival,…”
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No good deed goes unpunished by Ayala, Alfred, Wesche-Soldato, Doreen E, Garber, Megan, Swan, Ryan, Perl, Mario

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Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis by Ayala, Alfred, Wesche-Soldato, Doreen E, Perl, Mario, Lomas-Neira, Joanne L, Swan, Ryan, Chung, Chun-Shiang

“…Over time it has become clear that, much like other organ systems, the function and responsiveness of the immune system is impaired during the course of sepsis…”
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Developing pharmacy student empathy using mock HIV antiretroviral therapy regimens: A learning activity by Wesche-Szollosi, Doreen E., Ghoneim, Ola, Edafiogho, Ivan O., Ofosu, Joseph R.

“…To develop empathy among pharmacy students by utilizing a learning simulation of Human Immunodeficiency Virus (HIV) antiretroviral therapies in a first year…”
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MACROPHAGE ARGINASE REGULATION BY CCAAT/ENHANCER-BINDING PROTEIN ?? by Albina, Jorge E, Mahoney, Eric J, Daley, Jean M, Wesche, Doreen E, Morris, Sidney M, Reichner, Jonathan S

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The role and regulation of apoptosis in sepsis by Wesche-Soldato, Doreen E, Lomas-Neira, Joanne L, Perl, Mario, Jones, Leslie, Chung, Chun-Shiang, Ayala, Alfred

“…Today, sepsis continues to be a growing problem in the critically ill patient population. A number of laboratories have been interested in understanding how…”
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CD8+ T CELLS PROMOTE INFLAMMATION IN THE LIVER AFTER SEPSIS by Wesche-Soldato, Doreen E., Chung, Chun-Shiang, Ayala, Alfred

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