Search Results - "Wesa, Amy K"

Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI) by Balducci, Anthony, Helfer, Brooke M, Ahrens, Eric T, O'Hanlon, 3rd, Charles F, Wesa, Amy K

“…Non-invasive imaging of inflammation to measure the progression of autoimmune diseases, such as rheumatoid arthritis (RA), and to monitor responses to therapy…”
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Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients by Wesa, Amy K, Mandic, Maja, Taylor, Jennifer L, Moschos, Stergios, Kirkwood, John M, Kwok, William W, Finke, James Harold, Storkus, Walter J

“…Cancer patients frequently exhibit a deficiency in Type-1 (but not Type-2 or regulatory) CD4(+) T cell responses against tumor-associated antigens (TAA), which…”
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Effect of Renal Cell Carcinomas on the Development of Type 1 T-Cell Responses by RAYMAN, Patricia, WESA, Amy K, FINKE, James, RICHMOND, Amy L, DAS, Tanya, BISWAS, Kaushik, RAVAL, Gira, STORKUS, Walter J, TANNENBAUM, Charles, NOVICK, Andrew, BUKOWSKI, Ronald

“…Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly…”
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A novel probe for the non-invasive detection of tumor-associated inflammation by Balducci, Anthony, Wen, Yi, Zhang, Yang, Helfer, Brooke M., Hitchens, T. Kevin, Meng, Wilson S., Wesa, Amy K., Janjic, Jelena M.

“…A novel dual-mode contrast agent was formulated through the addition of an optical near infrared (NIR) probe to a perfluorocarbon (PFC)-based 19 F magnetic…”
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Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells by KAWABE, Mayumi, MANDIC, Maja, TAYLOR, Jennifer L, VASQUEZ, Cecilia A, WESA, Amy K, NECKERS, Leonard M, STORKUS, Walter J

“…EphA2, a member of the receptor tyrosine kinase family, is commonly expressed by a broad range of cancer types, where its level of (over)expression correlates…”
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Intralesional delivery of dendritic cells engineered to express T-bet promotes protective type 1 immunity and the normalization of the tumor microenvironment by Qu, Yanyan, Chen, Lu, Pardee, Angela D, Taylor, Jennifer L, Wesa, Amy K, Storkus, Walter J

“…T-bet (Tbx21), a T-box transcription factor, has been previously identified as a master regulator of type 1 T cell polarization. We have also recently shown…”
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DC expressing transgene Foxp3 are regulatory APC by Lipscomb, Michael W, Taylor, Jennifer L, Goldbach, Cristina J, Watkins, Simon C, Wesa, Amy K, Storkus, Walter J

“…Tolerogenic DC and suppressive Foxp3⁺ Treg play important roles in preventing autoimmunity and allograft rejection. We report that (adenovirus mediated)…”
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Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro by Lipscomb, Michael W, Chen, Lu, Taylor, Jennifer L, Goldbach, Christina, Watkins, Simon C, Kalinski, Pawel, Butterfield, Lisa H, Wesa, Amy K, Storkus, Walter J

“…T-bet (TBX21) is a transcription factor required for the optimal development of type 1 immune responses. Although initially characterized for its intrinsic…”
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Enhancement in Specific CD8+ T Cell Recognition of EphA2+ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists by Wesa, Amy K, Herrem, Christopher J, Mandic, Maja, Taylor, Jennifer L, Vasquez, Cecilia, Kawabe, Mayumi, Tatsumi, Tomohide, Leibowitz, Michael S, Finke, James H, Bukowski, Ronald M, Bruckheimer, Elizabeth, Kinch, Michael S, Storkus, Walter J

“…The EphA2 receptor tyrosine kinase is an attractive therapeutic target that is commonly overexpressed on solid tumors, with the degree of overexpression…”
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CD8+ T-cell responses against hemoglobin-beta prevent solid tumor growth by Komita, Hideo, Zhao, Xi, Taylor, Jennifer L, Sparvero, Louis J, Amoscato, Andrew A, Alber, Sean, Watkins, Simon C, Pardee, Angela D, Wesa, Amy K, Storkus, Walter J

“…Bone marrow-derived dendritic cells engineered using recombinant adenovirus to secrete high levels of IL-12p70 dramatically inhibited the growth of established…”
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IL-1β induces dendritic cells to produce IL-12 by Wesa, Amy K., Galy, Anne

“…The cytokine IL-12, a product of dendritic cells (DC), plays a major role in cellular immunity, notably by inducing lymphocytes to produce IFN-γ. Microbial…”
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Interferon-alpha (IFN-α)-conditioned DC Preferentially Stimulate Type-1 and Limit Treg-type In Vitro T-cell Responses From RCC Patients by GIGANTE, Margherita, MANDIC, Maja, WESA, Amy K, CAVALCANTI, Elisabetta, DAMBROSIO, Michele, MANCINI, Vito, BATTAGLIA, Michele, GESUALDO, Loreto, STORKUS, Walter J, RANIERI, Elena

“…Dendritic cells (DCs) are potent antigen presenting cells and represent attractive candidates for use in novel immunotherapies for patients with renal cell…”
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Integrating costimulatory agonists to optimize immune-based cancer therapies by Pardee, Angela D, Wesa, Amy K, Storkus, Walter J

“…While immunotherapy for cancer has become increasingly popular, clinical benefits for such approaches remain limited. This is likely due to tumor-associated…”
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Improving immunotherapy by conditionally enhancing MHC class I presentation of tumor antigen-derived Peptide epitopes by Storkus, Walter J, Herrem, Christopher, Kawabe, Mayumi, Cohen, Peter A, Bukowski, Ronald M, Finke, James H, Wesa, Amy K

“…Tumors represent an altered self cell type that can be recognized by both the host humoral (B cells, antibodies) and cellular (T cells) adaptive immune…”
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INTRALESIONAL DELIVERY OF DENDRITIC CELLS ENGINEERED TO EXPRESS T-BET PROMOTES PROTECTIVE TYPE-1 IMMUNITY AND THE NORMALIZATION OF THE TUMOR MICROENVIRONMENT1 by Qu, Yanyan, Chen, Lu, Pardee, Angela D., Taylor, Jennifer L., Wesa, Amy K., Storkus, Walter J.

“…T-bet (Tbx21), a T-box transcription factor, has been previously identified as a master regulator of Type-1 T cell polarization. We have also recently shown…”
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HSP90 inhibitor 17-DMAG enhances EphA2+ tumor cell recognition by specific CD8+ T cells by Kawabe, Mayumi, Mandic, Maja, Taylor, Jennifer L., Vasquez, Cecilia A., Wesa, Amy K., Neckers, Leonard M., Storkus, Walter J.

“…EphA2, a member of the receptor tyrosine kinase (RTK) family, is commonly expressed by a broad range of cancer types, where its level of (over)expression…”
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Ectopic T-bet expression licenses dendritic cells for interleukin (IL)-12-independent priming of Type-1 T cells in vitro1 by Lipscomb, Michael W., Chen, Lu, Taylor, Jennifer L., Goldbach, Christina, Watkins, Simon C., Kalinski, Pawel, Butterfield, Lisa H., Wesa, Amy K., Storkus, Walter J.

“…T-bet (TBX21) is a transcription factor required for the optimal development of Type-1 immune responses. While initially characterized for its intrinsic role…”
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Enhancement in Specific CD8+ T cell Recognition of EphA2+ Tumors In Vitro and In Vivo After Treatment with Ligand Agonists1 by Wesa, Amy K., Herrem, Christopher J., Mandic, Maja, Taylor, Jennifer L., Vasquez, Cecilia, Kawabe, Mayumi, Tatsumi, Tomohide, Leibowitz, Michael S., Finke, James H., Bukowski, Ronald M., Bruckheimer, Elizabeth, Kinch, Michael S., Storkus, Walter J.

“…The EphA2 receptor tyrosine kinase (RTK) is an attractive therapeutic target that is commonly overexpressed on solid tumors, with the degree of overexpression…”
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IL-1[beta] induces dendritic cells to produce IL-12 by Wesa, Amy K, Galy, Anne

“…The cytokine IL-12, a product of dendritic cells (DC), plays a major role in cellular immunity, notably by inducing lymphocytes to produce IFN-[gamma]…”
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CDB+ T-Cell Responses against Hemoglobin-β Prevent Solid Tumor Growth by KOMITA, Hideo, XI ZHAO, TAYLOR, Jennifer L, SPARVERO, Louis J, AMOSCATO, Andrew A, ALBER, Sean, WATKINS, Simon C, PARDEE, Angela D, WESA, Amy K, STORKUS, Walter J

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