Search Results - "Wertheimer, Stanley J."

Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site by Dunten, Pete, Belunis, Charles, Crowther, Robert, Hollfelder, Kurt, Kammlott, Ursula, Levin, Wayne, Michel, Hanspeter, Ramsey, Gwendolyn B, Swain, Amy, Weber, David, Wertheimer, Stanley J

“…We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to…”
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Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes by Qian, Yimin, Wertheimer, Stanley J, Ahmad, Mushtaq, Cheung, Adrian Wai-Hing, Firooznia, Fariborz, Hamilton, Matthew M, Hayden, Stuart, Li, Shiming, Marcopulos, Nicholas, McDermott, Lee, Tan, Jenny, Yun, Weiya, Guo, Liang, Pamidimukkala, Anjula, Chen, Yingsi, Huang, Kuo-Sen, Ramsey, Gwendolyn B, Whittard, Toni, Conde-Knape, Karin, Taub, Rebecca, Rondinone, Cristina M, Tilley, Jefferson, Bolin, David

“…Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of…”
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Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors by Yun, Weiya, Ahmad, Mushtaq, Chen, Yingsi, Gillespie, Paul, Conde-Knape, Karin, Kazmer, Sonja, Li, Shiming, Qian, Yimin, Taub, Rebecca, Wertheimer, Stanley J., Whittard, Toni, Bolin, David

“…The discovery and SAR studies of a phenyloxazole based diacylglycerol acyltransferase-1 inhibitor are reported. The optimized compound 25 is orally available…”
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C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase by Pietranico, Sherrie L., Foley, Louise H., Huby, Nicholas, Yun, Weiya, Dunten, Pete, Vermeulen, John, Wang, Ping, Toth, Katherine, Ramsey, Gwendolyn, Gubler, Mary-Lou, Wertheimer, Stanley J.

“…Enzyme and cellular assay results for a number of new modifications on the C-8 aminobenzyl unit are reported. Pyrazole sulfonic acid amide analogs are shown to…”
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Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells by Chen, Hui, Wertheimer, Stanley J., Lin, Chung H., Katz, Susan L., Amrein, Kurt E., Burn, Paul, Quon, Michael J.

“…The protein-tyrosine phosphatases PTP1B and Syp have both been implicated as modulators of the mitogenic actions of insulin. However, the roles of these…”
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Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover…”
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X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The…”
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Fatty acid modulators for the treatment of diabesity by Wertheimer, Stanley J, Bolin, David, Erickson, Shawn, Conde-Knape, Karin, Belunis, Charles, Konkar, Anish, Taub, Rebecca, Rondinone, Cristina M

“…Body weight is determined by the net difference in calorie consumption and energy expenditure. The balance between triglyceride biosynthesis and breakdown…”
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Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate by WERTHEIMER, S. J, MYERS, C. L, WALLACE, R. W, PARKS, T. P

“…Intercellular adhesion molecule-1 (ICAM-1) is an inducible glycoprotein expressed on the surface of inflamed endothelium which mediates in part the…”
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Transcriptional patterns for the thrS-infC-rplT operon of Escherichia coli by Wertheimer, S J, Klotsky, R A, Schwartz, I

“…The genes coding for threonyl-tRNA synthetase (thrS), translation initiation factor 3 (infC) and ribosomal protein L20 (rplT) are clustered in the Escherichia…”
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Changes in thymidine kinase activity during differentiation of HL-60 leukemic cells by Borelli, T J, Miyamoto, S, Wertheimer, S J, Wu, J M

“…Induction of granulocyte maturation in HL-60 leukemic cells by DMSO (1.2%) or RA (1 microM) is accompanied by a 50-60% decrease in cellular thymidine kinase…”
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Some properties of 2-5A binding/nucleolytic activities in gel filtered rabbit reticulocyte lysates by Wu, J M, Wertheimer, S J, Eslami, B, Figuereido, J C, Goswami, B B

“…Rabbit reticulocyte lysates, gel filtered on Sephadex G-25 with or without ATP (or its analogs), were preincubated at 37 degrees C and their subsequent binding…”
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