Search Results - "Wert, Susan"

Diseases of Pulmonary Surfactant Homeostasis by Whitsett, Jeffrey A, Wert, Susan E, Weaver, Timothy E

“…Advances in physiology and biochemistry have provided fundamental insights into the role of pulmonary surfactant in the pathogenesis and treatment of preterm…”
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Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease by Whitsett, Jeffrey A, Wert, Susan E, Weaver, Timothy E

“…The alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after…”
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Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells by Tompkins, David H, Besnard, Valérie, Lange, Alexander W, Wert, Susan E, Keiser, Angela R, Smith, April N, Lang, Richard, Whitsett, Jeffrey A

“…The bronchioles of the murine lung are lined by a simple columnar epithelium composed of ciliated, Clara, and goblet cells that together mediate barrier…”
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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production by Chen, Gang, Korfhagen, Thomas R, Xu, Yan, Kitzmiller, Joseph, Wert, Susan E, Maeda, Yutaka, Gregorieff, Alexander, Clevers, Hans, Whitsett, Jeffrey A

“…Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and…”
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Genotype-Phenotype Correlations for Infants and Children with ABCA3 Deficiency by WAMBACH, Jennifer A, CASEY, Alicia M, FISHMAN, Martha P, WEGNER, Daniel J, WERT, Susan E, COLE, F. Sessions, HAMVAS, Aaron, NOGEE, Lawrence M

“…Recessive mutations in the ATP-binding cassette transporter A3 (ABCA3) cause lethal neonatal respiratory failure and childhood interstitial lung disease. Most…”
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Heterogeneous Pulmonary Phenotypes Associated With Mutations in the Thyroid Transcription Factor Gene NKX2-1 by Hamvas, Aaron, MD, Deterding, Robin R., MD, Wert, Susan E., PhD, White, Frances V., MD, Dishop, Megan K., MD, Alfano, Danielle N., MD, Halbower, Ann C., MD, Planer, Benjamin, MD, Stephan, Mark J., MD, Uchida, Derek A., MD, Williames, Lee D., MD, Rosenfeld, Jill A., MS, Lebel, Robert Roger, MD, Young, Lisa R., MD, Cole, F. Sessions, MD, Nogee, Lawrence M., MD

“…Background Mutations in the gene encoding thyroid transcription factor, NKX2-1 , result in neurologic abnormalities, hypothyroidism, and neonatal respiratory…”
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Genetic Disorders of Surfactant Dysfunction by Wert, Susan E., Whitsett, Jeffrey A., Nogee, Lawrence M.

“…Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the phospholipid transporter, ABCA3, are associated with respiratory…”
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Transcriptional programs controlling perinatal lung maturation by Xu, Yan, Wang, Yanhua, Besnard, Valérie, Ikegami, Machiko, Wert, Susan E, Heffner, Caleb, Murray, Stephen A, Donahue, Leah Rae, Whitsett, Jeffrey A

“…The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in…”
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Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis by Luisetti, Maurizio, Sakagami, Takuro, Uchida, Kanji, Suzuki, Takuji, Carey, Brenna C, Wood, Robert E, Wert, Susan E, Whitsett, Jeffrey A, Trapnell, Bruce C

“…To the Editor: Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipids and proteins accumulate in pulmonary alveolar macrophages…”
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Sox2 activates cell proliferation and differentiation in the respiratory epithelium by Tompkins, David H, Besnard, Valérie, Lange, Alexander W, Keiser, Angela R, Wert, Susan E, Bruno, Michael D, Whitsett, Jeffrey A

“…Sox2, a transcription factor critical for the maintenance of embryonic stem cells and induction of pluripotent stem cells, is expressed exclusively in the…”
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Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA by Suzuki, Takuji, Sakagami, Takuro, Rubin, Bruce K, Nogee, Lawrence M, Wood, Robert E, Zimmerman, Sarah L, Smolarek, Teresa, Dishop, Megan K, Wert, Susan E, Whitsett, Jeffrey A, Grabowski, Gregory, Carey, Brenna C, Stevens, Carrie, van der Loo, Johannes C M, Trapnell, Bruce C

“…Primary pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation of surfactant in the lungs that is presumed to be mediated by…”
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Genome-Wide Transcriptional Profiling Reveals Connective Tissue Mast Cell Accumulation in Bronchopulmonary Dysplasia by BHATTACHARYA, Soumyaroop, GO, Diana, PRYHUBER, Gloria S, KRENITSKY, Daria L, HUYCK, Heidi L, KUMAR SOLLETI, Siva, LUNGER, Valerie A, METLAY, Leon, SRISUMA, Sorachai, WERT, Susan E, MARIANI, Thomas J

“…Bronchopulmonary dysplasia (BPD) is a major complication of premature birth. Risk factors for BPD are complex and include prenatal infection and O(2) toxicity…”
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Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis by Plantier, Laurent, Crestani, Bruno, Wert, Susan E, Dehoux, Monique, Zweytick, Barbara, Guenther, Andreas, Whitsett, Jeffrey A

“…Bronchiolisation of distal airspaces is an unexplained feature of idiopathic pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the…”
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R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis by Bell, Sheila M, Schreiner, Claire M, Wert, Susan E, Mucenski, Michael L, Scott, William J, Whitsett, Jeffrey A

“…Herein, we demonstrate that Lrp6-mediated R-spondin 2 signaling through the canonical Wnt pathway is required for normal morphogenesis of the respiratory tract…”
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Ontology-guided segmentation and object identification for developmental mouse lung immunofluorescent images by Masci, Anna Maria, White, Scott, Neely, Ben, Ardini-Polaske, Maryanne, Hill, Carol B, Misra, Ravi S, Aronow, Bruce, Gaddis, Nathan, Yang, Lina, Wert, Susan E, Palmer, Scott M, Chan, Cliburn

“…Immunofluorescent confocal microscopy uses labeled antibodies as probes against specific macromolecules to discriminate between multiple cell types. For images…”
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Sox17 is required for normal pulmonary vascular morphogenesis by Lange, Alexander W., Haitchi, Hans Michael, LeCras, Timothy D., Sridharan, Anusha, Xu, Yan, Wert, Susan E., James, Jeanne, Udell, Nicholas, Thurner, Philipp J., Whitsett, Jeffrey A.

“…The SRY-box containing transcription factor Sox17 is required for endoderm formation and vascular morphogenesis during embryonic development. In the lung,…”
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Hereditary Pulmonary Alveolar Proteinosis: Pathogenesis, Presentation, Diagnosis, and Therapy by SUZUKI, Takuji, SAKAGAMI, Takuro, WHITSETT, Jeffrey A, STEVENS, Carrie, NOGEE, Lawrence M, CAMPO, Ilaria, TRAPNELL, Bruce C, YOUNG, Lisa R, CAREY, Brenna C, WOOD, Robert E, LUISETTI, Maurizio, WERT, Susan E, RUBIN, Bruce K, KEVILL, Katharine, CHALK, Claudia

“…We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor…”
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Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung by Pan, Huaqin, Deutsch, Gail H, Wert, Susan E

“…Although the mouse is widely used to model human lung development, function, and disease, our understanding of the molecular mechanisms involved in…”
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Diffuse Lung Disease in Young Children: Application of a Novel Classification Scheme by Deutsch, Gail H, Young, Lisa R, Deterding, Robin R, Fan, Leland L, Dell, Sharon D, Bean, Judy A, Brody, Alan S, Nogee, Lawrence M, Trapnell, Bruce C, Langston, Claire, and Pathology Cooperative Group, Albright, Eric A, Askin, Frederic B, Baker, Peter, Chou, Pauline M, Cool, Carlyne M, Coventry, Susan C, Cutz, Ernest, Davis, Mary M, Dishop, Megan K, Galambos, Csaba, Patterson, Kathleen, Travis, William D, Wert, Susan E, White, Frances V, on behalf of ChILD Research Co-operative

“…Considerable confusion exists regarding nomenclature, classification, and management of pediatric diffuse lung diseases due to the relative rarity and…”
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ABCA3 Gene Mutations in Newborns with Fatal Surfactant Deficiency by Shulenin, Sergey, Nogee, Lawrence M, Annilo, Tarmo, Wert, Susan E, Whitsett, Jeffrey A, Dean, Michael

“…This study describes the genetic cause of some cases of fatal surfactant deficiency in newborns. The gene encoding ATP-binding cassette transporter A3 ( ABCA3…”
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