Search Results - "Wert, S."

Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin by Tunc-Ozcan, E, Wert, S L, Lim, P H, Ferreira, A, Redei, E E

“…Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2–11% of children worldwide, with no effective treatments…”
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Pilot validation of blood-based biomarkers during pregnancy and postpartum in women with prior or current depression by Redei, E. E., Ciolino, J. D., Wert, S. L., Yang, A., Kim, S., Clark, C., Zumpf, K. B., Wisner, K. L.

“…Major depressive disorder (MDD) is more common in women than in men, and evidence of gender-related subtypes of depression is emerging. Previously identified…”
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Genetic stress-reactivity, sex, and conditioning intensity affect stress-enhanced fear learning by Przybyl, K.J., Jenz, S.T., Lim, P.H., Ji, M.T., Wert, S.L., Luo, W., Gacek, S.A., Schaack, A.K., Redei, E.E.

“…•Stress-Enhanced Fear Learning and fear memory modified by genetic stress-sensitivity.•Stress-Enhanced Fear Learning and fear memory are highly…”
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Heterogeneous stock rats: a model to study the genetics of despair‐like behavior in adolescence by Holl, K., He, H., Wedemeyer, M., Clopton, L., Wert, S., Meckes, J. K., Cheng, R., Kastner, A., Palmer, A. A., Redei, E. E., Solberg Woods, L. C.

“…Major depressive disorder (MDD) is a complex illness caused by both genetic and environmental factors. Antidepressant resistance also has a genetic component…”
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Nature and nurture: environmental influences on a genetic rat model of depression by Mehta-Raghavan, N S, Wert, S L, Morley, C, Graf, E N, Redei, E E

“…In this study, we sought to learn whether adverse events such as chronic restraint stress (CRS), or ‘nurture’ in the form of environmental enrichment (EE),…”
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Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1 by Besnard, V, Wert, S E, Kaestner, K H, Whitsett, J A

“…Foxa1 is a member of the winged helix family of transcription factors that is expressed in epithelial cells of the conducting airways and in alveolar type II…”
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Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis by Plantier, Laurent, Crestani, Bruno, Wert, Susan E, Dehoux, Monique, Zweytick, Barbara, Guenther, Andreas, Whitsett, Jeffrey A

“…Bronchiolisation of distal airspaces is an unexplained feature of idiopathic pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the…”
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Allelic Heterogeneity in Hereditary Surfactant Protein B (SP-B) Deficiency by NOGEE, LAWRENCE M, WERT, SUSAN E, PROFFIT, SHERRI A, HULL, WILLIAM M, WHITSETT, JEFFREY A

“…Inability to produce surfactant protein B (SP-B) causes fatal neonatal respiratory disease. A frame-shift mutation (121ins2) is the predominant but not…”
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A Mutation in the Surfactant Protein C Gene Associated with Familial Interstitial Lung Disease by Nogee, Lawrence M, Dunbar, Alston E, Wert, Susan E, Askin, Frederic, Hamvas, Aaron, Whitsett, Jeffrey A

“…Interstitial lung diseases are a heterogeneous group of disorders that are poorly understood at a molecular level. 1 , 2 The cause is often unknown, and the…”
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Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung by Peters, K., Werner, S., Liao, X., Wert, S., Whitsett, J., Williams, L.

“…Mouse lung development begins when two lung buds sprout from the epithelium of the embryonic gut. Patterning of the airways is then accomplished by the…”
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Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice by Clark, J C, Wert, S E, Bachurski, C J, Stahlman, M T, Stripp, B R, Weaver, T E, Whitsett, J A

“…Surfactant protein B (SP-B) is an 8.7-kDa, hydrophobic protein that enhances the spreading and stability of surfactant phospholipids in the alveolus. To…”
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Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice by SUBRAMANIAM, A, JONES, W. K, GULICK, J, WERT, S, NEUMANN, J, ROBBINS, J

“…The intergenic region between the mouse alpha-myosin heavy chain (MHC) and beta-MHC genes was analyzed in terms of its ability to drive gene expression in…”
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Altered Surfactant Function and Structure in SP-A Gene Targeted Mice by Korfhagen, Thomas R., Bruno, Michael D., Ross, Gary F., Huelsman, Karen M., Ikegami, Machiko, Jobe, Alan H., Wert, Susan E., Stripp, Barry R., Morris, Randal E., Glasser, Stephan W., Bachurski, Cindy J., Iwamoto, Harriet S., Whitsett, Jeffrey A.

“…The surfactant protein A (SP-A) gene was disrupted by homologous recombination in embryonic stem cells that were used to generate homozygous SP-A-deficient…”
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Prolonged survival in hereditary surfactant protein B (SP-B) deficiency associated with a novel splicing mutation by DUNBAR, A. E, WERT, S. E, IKEGAMI, M, WHITSETT, J. A, HAMVAS, A, WHITE, F. V, PIEDBOEUF, B, JOBIN, C, GUTTENTAG, S, NOGEE, L. M

“…Hereditary surfactant protein B (SP-B) deficiency has been lethal in the first year of life without lung transplantation. We tested the hypothesis that SP-B…”
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Increased Metalloproteinase Activity, Oxidant Production, and Emphysema in Surfactant Protein D Gene-Inactivated Mice by Wert, Susan E., Yoshida, Mitsuhiro, LeVine, Ann Marie, Ikegami, Machiko, Jones, Tracy, Ross, Gary F., Fisher, James H., Korfhagen, Thomas R., Whitsett, Jeffrey A.

“…Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflammation, emphysema, and fibrosis in the lungs of SP-D (-/-) mice. Although lung…”
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Transcriptional Elements from the Human SP-C Gene Direct Expression in the Primordial Respiratory Epithelium of Transgenic Mice by Wert, Susan E., Glasser, Stephan W., Korfhagen, Thomas R., Whitsett, Jeffrey A.

“…Transgenic animals bearing a chimeric gene containing 5′-flanking regions of the human surfactant protein C (SPC) gene ligated to the bacterial chloramphenicol…”
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Correction of Lethal Intestinal Defect in a Mouse Model of Cystic Fibrosis by Human CFTR by Zhou, Lan, Dey, Chitta R., Wert, Susan E., DuVall, Michael D., Frizzell, Raymond A., Whitsett, Jeffrey A.

“…Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). A potential animal model of…”
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Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells by Ikeda, Kazushige, Shaw-White, Jessica R., Wert, Susan E., Whitsett, Jeffrey A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pulmonary Malformation in Transgenic Mice Expressing Human Keratinocyte Growth Factor in the Lung by Simonet, W S, DeRose, M L, Bucay, N, Nguyen, H Q, Wert, S E, Zhou, L, Ulich, T R, Thomason, A, Danilenko, D M, Whitsett, J A

“…Expression of human keratinocyte growth factor (KGF/FGF-7) was directed to epithelial cells of the developing embryonic lung of transgenic mice disrupting…”
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Deficiency of lamellar bodies in alveolar type II cells associated with fatal respiratory disease in a full-term infant by CUTZ, E, WERT, S. E, NOGEE, L. M, MOORE, A. M

“…We report a case of a full-term female infant who presented with severe respiratory distress shortly after birth and died at 23 d of age with unremitting…”
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