Search Results - "Wersto, Robert P."

Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells by Bodogai, Monica, Moritoh, Kanako, Lee-Chang, Catalina, Hollander, Christine M, Sherman-Baust, Cheryl A, Wersto, Robert P, Araki, Yoshihiko, Miyoshi, Ichiro, Yang, Li, Trinchieri, Giorgio, Biragyn, Arya

“…Myeloid-derived suppressive cells (MDSC) have been reported to promote metastasis, but the loss of cancer-induced B cells/B regulatory cells (tBreg) can block…”
Get full text

Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L by BODOGAI, Monica, CHANG, Catalina Lee, WEJKSZA, Katarzyna, JINPING LAI, MERINO, Maria, WERSTO, Robert P, GRESS, Ronald E, CHAN, Andrew C, HESDORFFER, Charles, BIRAGYN, Arya

“…The possible therapeutic benefits of B-cell depletion in combating tumoral immune escape have been debated. In support of this concept, metastasis of highly…”
Get full text

Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells by Valle, Blanca L, D'Souza, Theresa, Becker, Kevin G, Wood, 3rd, William H, Zhang, Yongqing, Wersto, Robert P, Morin, Patrice J

“…Epidemiological studies have shown that the regular use of non-steroidal anti-inflammatory (NSAIDs) drugs is associated with a reduced risk of various cancers…”
Get full text

Male rat leukocyte population dynamics predict a window for intervention in aging by Yanai, Hagai, Dunn, Christopher, Park, Bongsoo, Coletta, Christopher, McDevitt, Ross A, McNeely, Taylor, Leone, Michael, Wersto, Robert P, Perdue, Kathy A, Beerman, Isabel

“…Many age-associated changes in the human hematopoietic system have been reproduced in murine models; however, such changes have not been as robustly explored…”
Get full text

A Human Pluripotent Stem Cell Surface N-Glycoproteome Resource Reveals Markers, Extracellular Epitopes, and Drug Targets by Boheler, Kenneth R., Bhattacharya, Subarna, Kropp, Erin M., Chuppa, Sandra, Riordon, Daniel R., Bausch-Fluck, Damaris, Burridge, Paul W., Wu, Joseph C., Wersto, Robert P., Chan, Godfrey Chi Fung, Rao, Sridhar, Wollscheid, Bernd, Gundry, Rebekah L.

“…Detailed knowledge of cell-surface proteins for isolating well-defined populations of human pluripotent stem cells (hPSCs) would significantly enhance their…”
Get full text

Translational Control of TOP2A Influences Doxorubicin Efficacy by Srikantan, Subramanya, Abdelmohsen, Kotb, Lee, Eun Kyung, Tominaga, Kumiko, Subaran, Sarah S., Kuwano, Yuki, Kulshrestha, Ritu, Panchakshari, Rohit, Kim, Hyeon Ho, Yang, Xiaoling, Martindale, Jennifer L., Marasa, Bernard S., Kim, Mihee M., Wersto, Robert P., Indig, Fred E., Chowdhury, Dipanjan, Gorospe, Myriam

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability by BIBO YUAN, YI XU, WOO, Ju-Hyung, YUNYUE WANG, YOUNG KYUNG BAE, YOON, Dae-Sung, WERSTO, Robert P, TULLY, Ellen, WILSBACH, Kathleen, GABRIELSON, Edward

“…Purpose: Most breast cancers have chromosomal instability that seems related to defective mitotic spindle checkpoints. Because the molecular basis of this…”
Get full text

Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage by Kruman, Inna I, Wersto, Robert P, Cardozo-Pelaez, Fernando, Smilenov, Lubomir, Chan, Sic L, Chrest, Francis J, Emokpae, Roland, Gorospe, Myriam, Mattson, Mark P

“…Increasing evidence indicates that neurodegeneration involves the activation of the cell cycle machinery in postmitotic neurons. However, the purpose of these…”
Get full text

The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells by Zhan, Ming, Riordon, Daniel R, Yan, Bin, Tarasova, Yelena S, Bruweleit, Sarah, Tarasov, Kirill V, Li, Ronald A, Wersto, Robert P, Boheler, Kenneth R

“…Embryonic stem cells (ESCs) are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively,…”
Get full text

Krüppel‐like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL‐17 expression during Th17 differentiation by An, Jie, Golech, Susanne, Klaewsongkram, Jettanong, Zhang, Yongqing, Subedi, Kalpana, Huston, Gail E., Wood, William H., Wersto, Robert P., Becker, Kevin G., Swain, Susan L., Weng, Nanping

“…ABSTRACT Krüppel‐like factor 4 (KLF4), a transcription factor, plays a key role in the pluripotency of stem cells. We sought to determine the function of KLF4…”
Get full text

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells by Zhang, Peisu, Pazin, Michael J., Schwartz, Catherine M., Becker, Kevin G., Wersto, Robert P., Dilley, Caroline M., Mattson, Mark P.

“…Removal of TRF2, a telomere shelterin protein, recapitulates key aspects of telomere attrition including the DNA-damage response and cell-cycle arrest [1]…”
Get full text

Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma by Yamanaka, Satoshi, Zahanich, Ihor, Wersto, Robert P, Boheler, Kenneth R

“…Cardiomyocyte (CM) cell cycle analysis has been impeded because of a reliance on primary neonatal cultures of poorly proliferating cells or chronic transgenic…”
Get full text

B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells by Tarasov, Kirill V, Tarasova, Yelena S, Tam, Wai Leong, Riordon, Daniel R, Elliott, Steven T, Kania, Gabriela, Li, Jinliang, Yamanaka, Satoshi, Crider, David G, Testa, Gianluca, Li, Ronald A, Lim, Bing, Stewart, Colin L, Liu, Yie, Van Eyk, Jennifer E, Wersto, Robert P, Wobus, Anna M, Boheler, Kenneth R

“…The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation…”
Get full text

Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress by Liu, Dong, Chan, Sic L, de Souza-Pinto, Nadja C, Slevin, John R, Wersto, Robert P, Zhan, Ming, Mustafa, Khadija, de Cabo, Rafael, Mattson, Mark P

“…The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of…”
Get full text

Different Mutation Signatures in DNA Polymerase η- and MSH6-Deficient Mice Suggest Separate Roles in Antibody Diversification by Martomo, Stella A., Yang, William W., Wersto, Robert P., Ohkumo, Tsuyoshi, Kondo, Yuji, Yokoi, Masayuki, Masutani, Chikahide, Hanaoka, Fumio, Gearhart, Patricia J., Gellert, Martin

“…Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases…”
Get full text

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells by OLKHANUD, Purevdorj B, DAMDINSUREN, Bazarragchaa, BODOGAI, Monica, GRESS, Ronald E, SEN, Ranjan, WEJKSZA, Katarzyna, MALCHINKHUU, Enkhzol, WERSTO, Robert P, BIRAGYN, Arya

“…Pulmonary metastasis of breast cancer requires recruitment and expansion of T-regulatory cells (Treg) that promote escape from host protective immune cells…”
Get full text

Arsenic Trioxide Promotes Histone H3 Phosphoacetylation at the Chromatin of CASPASE-10 in Acute Promyelocytic Leukemia Cells by Li, Ji, Chen, Peili, Sinogeeva, Natasha, Gorospe, Myriam, Wersto, Robert P., Chrest, Francis J., Barnes, Janice, Liu, Yusen

“…Arsenic trioxide (As2O3) is highly effective for the treatment of acute promyelocytic leukemia, even in patients who are unresponsive to all-trans-retinoic…”
Get full text

Variable Levels of Chromosomal Instability and Mitotic Spindle Checkpoint Defects in Breast Cancer by Yoon, Dae-Sung, Wersto, Robert P., Zhou, Weibo, Chrest, Francis J., Garrett, Elizabeth S., Kwon, Teag Kyu, Gabrielson, Edward

“…Cytogenetic analyses have revealed that many aneuploid breast cancers have cell-to-cell variations of chromosome copy numbers, suggesting that these neoplasms…”
Get full text

Zscan4 regulates telomere elongation and genomic stability in ES cells by Ko, Minoru S. H, Zalzman, Michal, Falco, Geppino, Sharova, Lioudmila V, Nishiyama, Akira, Thomas, Marshall, Lee, Sung-Lim, Stagg, Carole A, Hoang, Hien G, Yang, Hsih-Te, Indig, Fred E, Wersto, Robert P

“…Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We…”
Get full text

Embryonic Stem Cell-Derived Cardiomyocyte Heterogeneity and the Isolation of Immature and Committed Cells for Cardiac Remodeling and Regeneration by Wersto, Robert P., Zhou, Rong, Boheler, Kenneth R., Gundry, Rebekah L., Chuppa, Sandra L., Urick, Amanda L., Joodi, Robert N., Qiao, Hui, Juhasz, Ondrej

“…Pluripotent stem cells represent one promising source for cell replacement therapy in heart, but differentiating embryonic stem cell-derived cardiomyocytes…”
Get full text