Search Results - "Wernstedt Asterholm, Ingrid"

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling by Wernstedt Asterholm, Ingrid, Tao, Caroline, Morley, Thomas S., Wang, Qiong A., Delgado-Lopez, Fernando, Wang, Zhao V., Scherer, Philipp E.

“…Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals…”
Get full text

Dichotomous effects of VEGF-A on adipose tissue dysfunction by Sun, Kai, Asterholm, Ingrid Wernstedt, Kusminski, Christine M, Bueno, Ana Carolina, Wang, Zhao V, Pollard, Jeffrey W, Brekken, Rolf A, Scherer, Philipp E

“…Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized…”
Get full text

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion by Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik

“…Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers…”
Get full text

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model by Benrick, Anna, Chanclón, Belén, Micallef, Peter, Wu, Yanling, Hadi, Laila, Shelton, John M., Stener-Victorin, Elisabet, Asterholm, Ingrid Wernstedt

“…Adiponectin, together with adipocyte size, is the strongest factor associated with insulin resistance in women with polycystic ovary syndrome (PCOS). This…”
Get full text

Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1 by Wernstedt Asterholm, Ingrid, Mundy, Dorothy I., Weng, Jian, Anderson, Richard G.W., Scherer, Philipp E.

“…Caveolin-1 is a major structural component of raft structures within the plasma membrane and has been implicated as a regulator of cellular signal transduction…”
Get full text

Comparing lipid remodeling of brown adipose tissue, white adipose tissue, and liver after one‐week high fat diet intervention with quantitative Raman microscopy by Paul, Alexandra, Chanclón, Belén, Brännmark, Cecilia, Wittung‐Stafshede, Pernilla, Olofsson, Charlotta S., Asterholm, Ingrid Wernstedt, Parekh, Sapun H.

“…Brown adipose tissue (BAT) consists of highly metabolically active adipocytes that catabolize nutrients to produce heat. Playing an active role in…”
Get full text

White Adipocyte Adiponectin Exocytosis Is Stimulated via β3-Adrenergic Signaling and Activation of Epac1: Catecholamine Resistance in Obesity and Type 2 Diabetes by Komai, Ali M, Musovic, Saliha, Peris, Eduard, Alrifaiy, Ahmed, El Hachmane, Mickaël F, Johansson, Marcus, Wernstedt Asterholm, Ingrid, Olofsson, Charlotta S

“…We investigated the physiological regulation of adiponectin exocytosis in health and metabolic disease by a combination of membrane capacitance patch-clamp…”
Get full text

Acute fat loss does not affect bone mass by Lagerquist, Marie K., Gustafsson, Karin L., Henning, Petra, Farman, Helen, Wu, Jianyao, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha, Ohlsson, Claes, Wernstedt Asterholm, Ingrid, Grahnemo, Louise

“…Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent…”
Get full text

Suppressing adipocyte inflammation promotes insulin resistance in mice by Zhu, Qingzhang, An, Yu A., Kim, Min, Zhang, Zhuzhen, Zhao, Shangang, Zhu, Yi, Asterholm, Ingrid Wernstedt, Kusminski, Christine M., Scherer, Philipp E.

“…Obesity-induced insulin resistance is closely associated with chronic subclinical inflammation in white adipose tissue. However, the mechanistic involvement of…”
Get full text

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes by Kim, Angela, Knudsen, Jakob G, Madara, Joseph C, Benrick, Anna, Hill, Thomas G, Abdul Kadir, Lina, Kellard, Joely A, Mellander, Lisa, Miranda, Caroline, Lin, Haopeng, James, Timothy, Suba, Kinga, Spigelman, Aliya F, Wu, Yanling, MacDonald, Patrick E, Wernstedt Asterholm, Ingrid, Magnussen, Tore, Christensen, Mikkel, Vilsbøll, Tina, Salem, Victoria, Knop, Filip K, Rorsman, Patrik, Lowell, Bradford B, Briant, Linford Jb

“…Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating…”
Get full text

Adipose Tissue-Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth by Micallef, Peter, Wu, Yanling, Bauzá-Thorbrügge, Marco, Chanclón, Belén, Vujičić, Milica, Peris, Eduard, Ek, C Joakim, Wernstedt Asterholm, Ingrid

“…We sought to identify therapeutic targets for breast cancer by investigating the metabolic symbiosis between breast cancer and adipose tissue. To this end, we…”
Get full text

Elevated circulating adiponectin levels do not prevent anxiety-like behavior in a PCOS-like mouse model by Samad, Manisha, Ek, Joakim, Börchers, Stina, Krieger, Jean-Philippe, Stener-Victorin, Elisabet, Skibicka, Karolina P., Asterholm, Ingrid Wernstedt, Benrick, Anna

“…Polycystic ovary syndrome (PCOS) is associated with symptoms of moderate to severe anxiety and depression. Hyperandrogenism is a key feature together with…”
Get full text

Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes by Peris, Eduard, Micallef, Peter, Paul, Alexandra, Palsdottir, Vilborg, Enejder, Annika, Bauzá-Thorbrügge, Marco, Olofsson, Charlotta S., Wernstedt Asterholm, Ingrid

“…β-Adrenergic stimulation of adipose tissue increases mitochondrial density and activity (browning) that are associated with improved whole-body metabolism…”
Get full text

Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages by Fischer-Posovszky, Pamela, Wang, Qiong A, Asterholm, Ingrid Wernstedt, Rutkowski, Joseph M, Scherer, Philipp E

“…Obesity is frequently associated with an infiltration of macrophages into adipose tissue. Adipocyte dysfunction causes a phenotypic switch of macrophages from…”
Get full text

Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice by Nuñez-Durán, Esther, Chanclón, Belén, Sütt, Silva, Real, Joana, Marschall, Hanns-Ulrich, Wernstedt Asterholm, Ingrid, Cansby, Emmelie, Mahlapuu, Margit

“…Characterising the molecular networks that negatively regulate pancreatic β-cell function is essential for understanding the underlying pathogenesis and…”
Get full text

Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS by Stener-Victorin, Elisabet, Eriksson, Gustaw, Mohan Shrestha, Man, Rodriguez Paris, Valentina, Lu, Haojiang, Banks, Jasmine, Samad, Manisha, Perian, Charlène, Jude, Baptiste, Engman, Viktor, Boi, Roberto, Nilsson, Emma, Ling, Charlotte, Nyström, Jenny, Wernstedt Asterholm, Ingrid, Turner, Nigel, Lanner, Johanna, Benrick, Anna

“…Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders. Gene expression analyses in…”
Get full text

Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice by Xia, Ying, Andersson, Emma, Caputo, Mara, Cansby, Emmelie, Sedda, Francesca, Font-Gironès, Ferran, Ruud, Johan, Kurhe, Yeshwant, Hallberg, Bengt, Marschall, Hanns-Ulrich, Asterholm, Ingrid Wernstedt, Romeo, Stefano, Blüher, Matthias, Mahlapuu, Margit

“…Abstract Objective Non-alcoholic fatty liver disease (NAFLD), the primary hepatic consequence of obesity, is affecting about 25% of the global adult…”
Get full text

Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice by Mohan Shrestha, Man, Wermelin, Sanne, Stener-Victorin, Elisabet, Wernstedt Asterholm, Ingrid, Benrick, Anna

“…Adiponectin administration to pregnant mice decreases nutrient transport and fetal growth. An adiponectin deficiency, on the other hand, as seen in obese women…”
Get full text

Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism by Mishra, Devesh, Richard, Jennifer E., Maric, Ivana, Porteiro, Begona, Häring, Martin, Kooijman, Sander, Musovic, Saliha, Eerola, Kim, López-Ferreras, Lorena, Peris, Eduard, Grycel, Katarzyna, Shevchouk, Olesya T., Micallef, Peter, Olofsson, Charlotta S., Wernstedt Asterholm, Ingrid, Grill, Harvey J., Nogueiras, Ruben, Skibicka, Karolina P.

“…Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls…”
Get full text

C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization by Micallef, Peter, Vujičić, Milica, Wu, Yanling, Peris, Eduard, Wang, Ying, Chanclón, Belén, Ståhlberg, Anders, Cardell, Susanna L., Wernstedt Asterholm, Ingrid

“…The adipose tissue undergoes substantial tissue remodeling during weight gain-induced expansion as well as in response to the mechanical and immunological…”
Get full text