Search Results - "Werner, Sabine"

Fibroblast growth factors: key players in regeneration and tissue repair by Maddaluno, Luigi, Urwyler, Corinne, Werner, Sabine

“…Tissue injury initiates a complex repair process, which in some organisms can lead to the complete regeneration of a tissue. In mammals, however, the repair of…”
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Regulation of Wound Healing by the NRF2 Transcription Factor-More Than Cytoprotection by Hiebert, Paul, Werner, Sabine

“…The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their…”
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Cancer as an overhealing wound: an old hypothesis revisited by Werner, Sabine, Schäfer, Matthias

“…Key Points A series of clinical and preclinical findings suggest a relationship between wound repair and cancer: malignant tumours often develop at sites of…”
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Keratinocyte–Fibroblast Interactions in Wound Healing by Werner, Sabine, Krieg, Thomas, Smola, Hans

“…Cutaneous tissue repair aims at restoring the barrier function of the skin. To achieve this, defects need to be replaced by granulation tissue to form new…”
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The bright and the dark sides of activin in wound healing and cancer by Antsiferova, Maria, Werner, Sabine

“…Activin was initially described as a protein that stimulates release of follicle stimulating hormone from the pituitary, and it is well known for its important…”
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Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice by Joshi, Natasha, Werner, Sabine

“…Immune cells of the myeloid lineage are key players in skin wound healing, since they secrete various cytokines and growth factors that orchestrate the repair…”
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NRF2 and microRNAs: new but awaited relations by Kurinna, Svitlana, Werner, Sabine

“…The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various…”
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Regulation of wound healing by growth factors and cytokines by Werner, Sabine, Grose, Richard

“…Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described…”
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The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin by Di Domizio, Jeremy, Belkhodja, Cyrine, Chenuet, Pauline, Fries, Anissa, Murray, Timothy, Mondéjar, Paula Marcos, Demaria, Olivier, Conrad, Curdin, Homey, Bernhard, Werner, Sabine, Speiser, Daniel E., Ryffel, Bernhard, Gilliet, Michel

“…Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role…”
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A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair by Telorack, Michèle, Meyer, Michael, Ingold, Irina, Conrad, Marcus, Bloch, Wilhelm, Werner, Sabine

“…The tripeptide glutathione is the most abundant cellular antioxidant with high medical relevance, and it is also required as a co-factor for various enzymes…”
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Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome by Hiebert, Paul, Wietecha, Mateusz S., Cangkrama, Michael, Haertel, Eric, Mavrogonatou, Eleni, Stumpe, Michael, Steenbock, Heiko, Grossi, Serena, Beer, Hans-Dietmar, Angel, Peter, Brinckmann, Jürgen, Kletsas, Dimitris, Dengjel, Jörn, Werner, Sabine

“…Nrf2 is a key regulator of the antioxidant defense system, and pharmacological Nrf2 activation is a promising strategy for cancer prevention and promotion of…”
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Injury-activated glial cells promote wound healing of the adult skin in mice by Parfejevs, Vadims, Debbache, Julien, Shakhova, Olga, Schaefer, Simon M., Glausch, Mareen, Wegner, Michael, Suter, Ueli, Riekstina, Una, Werner, Sabine, Sommer, Lukas

“…Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral…”
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Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals by Werner, Sabine, Nies, Eberhard

“…Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive…”
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Transcriptional control of wound repair by Schäfer, Matthias, Werner, Sabine

“…Injury to the skin initiates a complex process of events involving inflammation as well as the formation and remodeling of new tissue. These processes result…”
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NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair by Yan, Shen, Ripamonti, Raphael, Kawabe, Hiroshi, Ben-Yehuda Greenwald, Maya, Werner, Sabine

“…The ubiquitin ligase NEDD4-1 plays key roles in organ development, tissue homeostasis, and cancer, but its functions in the skin are largely unknown. In this…”
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Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds by Wietecha, Mateusz S., Pensalfini, Marco, Cangkrama, Michael, Müller, Bettina, Jin, Juyoung, Brinckmann, Jürgen, Mazza, Edoardo, Werner, Sabine

“…Matrix deposition is essential for wound repair, but when excessive, leads to hypertrophic scars and fibrosis. The factors that control matrix deposition in…”
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An important role of lymphatic vessel activation in limiting acute inflammation by Huggenberger, Reto, Siddiqui, Shoib S., Brander, Daniela, Ullmann, Stefan, Zimmermann, Kathrin, Antsiferova, Maria, Werner, Sabine, Alitalo, Kari, Detmar, Michael

“…In contrast to the established role of blood vessel remodeling in inflammation, the biologic function of the lymphatic vasculature in acute inflammation has…”
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Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma by Yerly, Laura, Pich-Bavastro, Christine, Di Domizio, Jeremy, Wyss, Tania, Tissot-Renaud, Stéphanie, Cangkrama, Michael, Gilliet, Michel, Werner, Sabine, Kuonen, François

“…Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential…”
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HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers by Khambu, Bilon, Huda, Nazmul, Chen, Xiaoyun, Antoine, Daniel J, Li, Yong, Dai, Guoli, Köhler, Ulrike A, Zong, Wei-Xing, Waguri, Satoshi, Werner, Sabine, Oury, Tim D, Dong, Zheng, Yin, Xiao-Ming

“…Autophagy is important for liver homeostasis, and the deficiency leads to injury, inflammation, ductular reaction (DR), fibrosis, and tumorigenesis. It is not…”
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MicroRNA therapy for infected wounds by Hiebert, Paul, Werner, Sabine

“…A novel approach for identification of functional miRNAs in skin wounds reveals miR‐223 as a key regulator of inflammation during tissue repair. The findings…”
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