Search Results - "Werner, Hendrikje"

Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy by Chai, Ruth Jinfen, Werner, Hendrikje, Li, Peter Yiqing, Lee, Yin Loon, Nyein, Khaing Thet, Solovei, Irina, Luu, Tuan Danh Anh, Sharma, Bhavya, Navasankari, Raju, Maric, Martina, Sim, Lois Yu En, Loh, Ying Jie, Aliwarga, Edita, Cheong, Jason Wen Long, Chojnowski, Alexandre, Autio, Matias Ilmari, Haiyang, Yu, Boon Tan, Kenneth Kian, Keng, Choong Tat, Ng, Shi Ling, Chew, Wei Leong, Ferenczi, Michael, Burke, Brian, Foo, Roger Sik Yin, Stewart, Colin L.

“…Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop…”
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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity by Tan, Chia Yee, Chan, Pui Shi, Tan, Hansen, Tan, Sung Wei, Lee, Chang Jie Mick, Wang, Jiong-Wei, Ye, Shu, Werner, Hendrikje, Loh, Ying Jie, Lee, Yin Loon, Ackers-Johnson, Matthew, Foo, Roger S. Y, Jiang, Jianming

“…Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have…”
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Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus by Imielski, Yvonne, Schwamborn, Jens C, Lüningschrör, Patrick, Heimann, Peter, Holzberg, Magdalena, Werner, Hendrikje, Leske, Oliver, Püschel, Andreas W, Memet, Sylvie, Heumann, Rolf, Israel, Alain, Kaltschmidt, Christian, Kaltschmidt, Barbara

“…Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated…”
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The DtxR protein acting as dual transcriptional regulator directs a global regulatory network involved in iron metabolism of Corynebacterium glutamicum by Brune, Iris, Werner, Hendrikje, Hüser, Andrea T, Kalinowski, Jörn, Pühler, Alfred, Tauch, Andreas

“…The knowledge about complete bacterial genome sequences opens the way to reconstruct the qualitative topology and global connectivity of transcriptional…”
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Rheb and mTOR Regulate Neuronal Polarity through Rap1B by Li, Ying-Hua, Werner, Hendrikje, Püschel, Andreas W.

“…The development of polarized hippocampal neurons with a single axon and multiple dendrites depends on the activity of phosphoinositide 3-kinase (PI3K) and the…”
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Nesprin-1 LINC complexes recruit microtubule cytoskeleton proteins and drive pathology in Lmna-mutant striated muscle by Leong, Ei Leen, Khaing, Nyein Thet, Cadot, Bruno, Hong, Wei Liang, Kozlov, Serguei, Werner, Hendrikje, Wong, Esther Sook Miin, Stewart, Colin L, Burke, Brian, Lee, Yin Loon

“…Mutations in LMNA, the gene encoding A-type lamins, cause laminopathies-diseases of striated muscle and other tissues. The aetiology of laminopathies has been…”
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Abstract 13927: AAV Gene Therapy to Treat Underlying Cardiac Biomechanical Defects in Lmna Dilated Cardiomyopathy Improves Lifespan and Preserves Ejection Fraction in Lmna DCM Mouse Model by Werner, Hendrikje, Gan, Esther S, Loh, Connie Y, Khaing, Nyein Thet, Zhang, Jinqiu, Ong, Mervyn, Burke, Brian, Tan, Yann Chong, Stewart, Colin L, Lee, Yin Loon

“…Mutations in the LMNA gene are the second most common cause of genetic dilated cardiomyopathies (DCMs) with a prevalence of ~1/12500. Adeno-associated virus…”
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Abstract 12498: AAV-Mediated LINC Complex Uncoupling Ameliorates Pathology in a Mouse Model of LMNA Dilated Cardiomyopathy by Werner, Hendrikje, Gan, Esther S, Loh, Connie, Ng, Jennifer, Khaing, Nyein Thet, Zhang, Jinqiu, Ong, Mervyn, Lee, John, Russell, David W, Tan, Yann Chong, Stewart, Colin, Burke, Brian, Lee, Yin Loon

“…Abstract only Mutations in the LMNA gene, encoding lamin A/C, are one of the most frequent genetic causes of dilated cardiomyopathy. While gene therapy using…”
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Protein-Protein Interaction Mapping by 2C-BioID by Chojnowski, Alexandre, Werner, Hendrikje, Cook, Matthew, Sobota, Radoslaw M, Burke, Brian, Stewart, Colin L

“…Protein-protein interactions (PPIs) add an essential layer of complexity to the information encoded by the genome. Modulation of such interactions is a key…”
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Dynamic composition of the nuclear envelope during mouse pre-implantation development by Werner, Hendrikje, Stewart, Colin

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Rheb and mTOR Regulate Neuronal Polarity through Rap1BS by Li, Ying-Hua, Werner, Hendrikje, Püschel, Andreas W.

“…The development of polarized hippocampal neurons with a single axon and multiple dendrites depends on the activity of phosphoinositide 3-kinase (PI3K) and the…”
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Regrowing the Adult Brain: NF-[kappa]B Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus by Imielski, Yvonne, Schwamborn, Jens C, Lüningschrör, Patrick, Heimann, Peter, Holzberg, Magdalena, Werner, Hendrikje, Leske, Oliver, Püschel, Andreas W, Memet, Sylvie, Heumann, Rolf, Israel, Alain, Kaltschmidt, Christian, Kaltschmidt, Barbara

“…Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated…”
Get full text