Search Results - "Werner, Hauke B"

Myelination of the Nervous System: Mechanisms and Functions by Nave, Klaus-Armin, Werner, Hauke B

“…Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse propagation, one of the best-understood concepts in neurophysiology…”
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Ensheathment and Myelination of Axons: Evolution of Glial Functions by Nave, Klaus-Armin, Werner, Hauke B

“…Myelination of axons provides the structural basis for rapid saltatory impulse propagation along vertebrate fiber tracts, a well-established neurophysiological…”
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Oligodendrocytes support axonal transport and maintenance via exosome secretion by Frühbeis, Carsten, Kuo-Elsner, Wen Ping, Müller, Christina, Barth, Kerstin, Peris, Leticia, Tenzer, Stefan, Möbius, Wiebke, Werner, Hauke B, Nave, Klaus-Armin, Fröhlich, Dominik, Krämer-Albers, Eva-Maria

“…Neurons extend long axons that require maintenance and are susceptible to degeneration. Long-term integrity of axons depends on intrinsic mechanisms including…”
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Myelin Proteomics: Molecular Anatomy of an Insulating Sheath by Jahn, Olaf, Tenzer, Stefan, Werner, Hauke B

“…Fast-transmitting vertebrate axons are electrically insulated with multiple layers of nonconductive plasma membrane of glial cell origin, termed myelin. The…”
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Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin by Snaidero, Nicolas, Velte, Caroline, Myllykoski, Matti, Raasakka, Arne, Ignatev, Alexander, Werner, Hauke B., Erwig, Michelle S., Möbius, Wiebke, Kursula, Petri, Nave, Klaus-Armin, Simons, Mikael

“…The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent…”
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Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin by Wakhloo, Debia, Scharkowski, Franziska, Curto, Yasmina, Javed Butt, Umer, Bansal, Vikas, Steixner-Kumar, Agnes A., Wüstefeld, Liane, Rajput, Ashish, Arinrad, Sahab, Zillmann, Matthias R., Seelbach, Anna, Hassouna, Imam, Schneider, Katharina, Qadir Ibrahim, Abdul, Werner, Hauke B., Martens, Henrik, Miskowiak, Kamilla, Wojcik, Sonja M., Bonn, Stefan, Nacher, Juan, Nave, Klaus-Armin, Ehrenreich, Hannelore

“…Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed…”
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White matter integrity in mice requires continuous myelin synthesis at the inner tongue by Meschkat, Martin, Steyer, Anna M., Weil, Marie-Theres, Kusch, Kathrin, Jahn, Olaf, Piepkorn, Lars, Agüi-Gonzalez, Paola, Phan, Nhu Thi Ngoc, Ruhwedel, Torben, Sadowski, Boguslawa, Rizzoli, Silvio O., Werner, Hauke B., Ehrenreich, Hannelore, Nave, Klaus-Armin, Möbius, Wiebke

“…Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises…”
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The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay by Jahn, Olaf, Siems, Sophie B, Kusch, Kathrin, Hesse, Dörte, Jung, Ramona B, Liepold, Thomas, Uecker, Marina, Sun, Ting, Werner, Hauke B

“…Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional…”
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Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia by Trevisiol, Andrea, Kusch, Kathrin, Steyer, Anna M, Gregor, Ingo, Nardis, Christos, Winkler, Ulrike, Köhler, Susanne, Restrepo, Alejandro, Möbius, Wiebke, Werner, Hauke B, Nave, Klaus-Armin, Hirrlinger, Johannes

“…In several neurodegenerative disorders, axonal pathology may originate from impaired oligodendrocyte-to-axon support of energy substrates. We previously…”
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Proteome profile of peripheral myelin in healthy mice and in a neuropathy model by Siems, Sophie B, Jahn, Olaf, Eichel, Maria A, Kannaiyan, Nirmal, Wu, Lai Man N, Sherman, Diane L, Kusch, Kathrin, Hesse, Dörte, Jung, Ramona B, Fledrich, Robert, Sereda, Michael W, Rossner, Moritz J, Brophy, Peter J, Werner, Hauke B

“…Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin…”
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Molecular evolution of myelin basic protein, an abundant structural myelin component by Nawaz, Schanila, Schweitzer, Jörn, Jahn, Olaf, Werner, Hauke B.

“…Rapid nerve conduction in jawed vertebrates is facilitated by the myelination of axons, which evolved in ancient cartilaginous fish. We aim to understand the…”
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Cortical network dysfunction caused by a subtle defect of myelination by Poggi, Giulia, Boretius, Susann, Möbius, Wiebke, Moschny, Nicole, Baudewig, Jürgen, Ruhwedel, Torben, Hassouna, Imam, Wieser, Georg L., Werner, Hauke B., Goebbels, Sandra, Nave, Klaus-Armin, Ehrenreich, Hannelore

“…Subtle white matter abnormalities have emerged as a hallmark of brain alterations in magnetic resonance imaging or upon autopsy of mentally ill subjects…”
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Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice by Gargareta, Vasiliki-Ilya, Reuschenbach, Josefine, Siems, Sophie B, Sun, Ting, Piepkorn, Lars, Mangana, Carolina, Späte, Erik, Goebbels, Sandra, Huitinga, Inge, Möbius, Wiebke, Nave, Klaus-Armin, Jahn, Olaf, Werner, Hauke B

“…Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to…”
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CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves by Eichel, Maria A., Gargareta, Vasiliki-Ilya, D’Este, Elisa, Fledrich, Robert, Kungl, Theresa, Buscham, Tobias J., Lüders, Katja A., Miracle, Cristina, Jung, Ramona B., Distler, Ute, Kusch, Kathrin, Möbius, Wiebke, Hülsmann, Swen, Tenzer, Stefan, Nave, Klaus-Armin, Werner, Hauke B.

“…The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid…”
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Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy by Kettwig, Matthias, Ternka, Katharina, Wendland, Kristin, Krüger, Dennis Manfred, Zampar, Silvia, Schob, Charlotte, Franz, Jonas, Aich, Abhishek, Winkler, Anne, Sakib, M. Sadman, Kaurani, Lalit, Epple, Robert, Werner, Hauke B., Hakroush, Samy, Kitz, Julia, Prinz, Marco, Bartok, Eva, Hartmann, Gunther, Schröder, Simone, Rehling, Peter, Henneke, Marco, Boretius, Susann, Alia, A., Wirths, Oliver, Fischer, Andre, Stadelmann, Christine, Nessler, Stefan, Gärtner, Jutta

“…Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and…”
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Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin by Erwig, Michelle S, Patzig, Julia, Steyer, Anna M, Dibaj, Payam, Heilmann, Mareike, Heilmann, Ingo, Jung, Ramona B, Kusch, Kathrin, Möbius, Wiebke, Jahn, Olaf, Nave, Klaus-Armin, Werner, Hauke B

“…Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath…”
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Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction by Patzig, Julia, Erwig, Michelle S, Tenzer, Stefan, Kusch, Kathrin, Dibaj, Payam, Möbius, Wiebke, Goebbels, Sandra, Schaeren-Wiemers, Nicole, Nave, Klaus-Armin, Werner, Hauke B

“…Myelination of axons facilitates rapid impulse propagation in the nervous system. The axon/myelin-unit becomes impaired in myelin-related disorders and upon…”
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Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance by Mita, Sakura, de Monasterio-Schrader, Patricia, Fünfschilling, Ursula, Kawasaki, Takahiko, Mizuno, Hidenobu, Iwasato, Takuji, Nave, Klaus-Armin, Werner, Hauke B, Hirata, Tatsumi

“…The function of mature neurons critically relies on the developmental outgrowth and projection of their cellular processes. It has long been postulated that…”
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A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system by Werner, Hauke B., Krämer-Albers, Eva-Maria, Strenzke, Nicola, Saher, Gesine, Tenzer, Stefan, Ohno-Iwashita, Yoshiko, De Monasterio-Schrader, Patricia, Möbius, Wiebke, Moser, Tobias, Griffiths, Ian R., Nave, Klaus-Armin

“…The formation of central nervous system myelin by oligodendrocytes requires sterol synthesis and is associated with a significant enrichment of cholesterol in…”
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Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity by Arinrad, Sahab, Depp, Constanze, Siems, Sophie B, Sasmita, Andrew Octavian, Eichel, Maria A, Ronnenberg, Anja, Hammerschmidt, Kurt, Lüders, Katja A, Werner, Hauke B, Ehrenreich, Hannelore, Nave, Klaus-Armin

“…A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar…”
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