Search Results - "Werner, Georg"

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury by Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian

“…Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such…”
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Calcium Carbide: A Unique Reagent for Organic Synthesis and Nanotechnology by Rodygin, Konstantin S., Werner, Georg, Kucherov, Fedor A., Ananikov, Valentine P.

“…Acetylene, HC≡CH, is one of the primary building blocks in synthetic organic and industrial chemistry. Several highly valuable processes have been developed…”
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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian

“…Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid…”
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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region by Schlepckow, Kai, Monroe, Kathryn M, Kleinberger, Gernot, Cantuti‐Castelvetri, Ludovico, Parhizkar, Samira, Xia, Dan, Willem, Michael, Werner, Georg, Pettkus, Nadine, Brunner, Bettina, Sülzen, Alice, Nuscher, Brigitte, Hampel, Heike, Xiang, Xianyuan, Feederle, Regina, Tahirovic, Sabina, Park, Joshua I, Prorok, Rachel, Mahon, Cathal, Liang, Chun‐Chi, Shi, Ju, Kim, Do Jin, Sabelström, Hanna, Huang, Fen, Di Paolo, Gilbert, Simons, Mikael, Lewcock, Joseph W, Haass, Christian

“…Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for the transition of homeostatic microglia to a disease‐associated microglial state. To…”
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Best-fitting growth curves of the von Bertalanffy-Pütter type by Kühleitner, Manfred, Brunner, Norbert, Nowak, Werner-Georg, Renner-Martin, Katharina, Scheicher, Klaus

“…A large body of literature aims at identifying growth models that fit best to given mass-at-age data. The von Bertalanffy-Pütter differential equation is a…”
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Best fitting tumor growth models of the von Bertalanffy-PütterType by Kühleitner, Manfred, Brunner, Norbert, Nowak, Werner-Georg, Renner-Martin, Katharina, Scheicher, Klaus

“…Longitudinal studies of tumor volume have used certain named mathematical growth models. The Bertalanffy-Pütter differential equation unifies them: It uses…”
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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 by Nihei, Yoshihiro, Mori, Kohji, Werner, Georg, Arzberger, Thomas, Zhou, Qihui, Khosravi, Barham, Japtok, Julia, Hermann, Andreas, Sommacal, Andreas, Weber, Markus, Kamp, Frits, Nuscher, Brigitte, Edbauer, Dieter, Haass, Christian

“…Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in…”
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Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice by Götzl, Julia K, Colombo, Alessio-Vittorio, Fellerer, Katrin, Reifschneider, Anika, Werner, Georg, Tahirovic, Sabina, Haass, Christian, Capell, Anja

“…Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to frontotemporal lobar degeneration (FTLD) while the complete loss of progranulin…”
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Improved Syntheses of 1,2‐Disubstituted Ferrocenes by Werner, Georg, Butenschön, Holger

“…1,2‐Disubstituted ferrocenes, in particular 1,2‐dihaloferrocenes, are important starting materials. Herein, we describe significantly improved high‐yielding…”
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Anionic Thia-Fries Rearrangements of Electron-Rich Ferrocenes and the Unanticipated Formation of Diferrocenyl Sulfate from 2‑(Trimethylsilyl)ferrocenyl Imidazolylsulfonate by Werner, Georg, Butenschön, Holger

“…Upon ortho lithiation ferrocenyl triflate and 1,1′-ferrocenediyl ditriflate undergo anionic thia-Fries rearrangements instead of triflate elimination. To…”
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Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study by AlTarabeen, Mousa, Al-Balas, Qosay, Albohy, Amgad, Müller, Werner Ernst Georg, Proksch, Peter

“…Manzamines are chemically related compounds extracted from the methanolic extract of species. Seven compounds were identified by our research group and are…”
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Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism by Götzl, Julia K, Brendel, Matthias, Werner, Georg, Parhizkar, Samira, Sebastian Monasor, Laura, Kleinberger, Gernot, Colombo, Alessio‐Vittorio, Deussing, Maximilian, Wagner, Matias, Winkelmann, Juliane, Diehl‐Schmid, Janine, Levin, Johannes, Fellerer, Katrin, Reifschneider, Anika, Bultmann, Sebastian, Bartenstein, Peter, Rominger, Axel, Tahirovic, Sabina, Smith, Scott T, Madore, Charlotte, Butovsky, Oleg, Capell, Anja, Haass, Christian

“…Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of…”
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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons by Lüningschrör, Patrick, Werner, Georg, Stroobants, Stijn, Kakuta, Soichiro, Dombert, Benjamin, Sinske, Daniela, Wanner, Renate, Lüllmann-Rauch, Renate, Wefers, Benedikt, Wurst, Wolfgang, D’Hooge, Rudi, Uchiyama, Yasuo, Sendtner, Michael, Haass, Christian, Saftig, Paul, Knöll, Bernd, Capell, Anja, Damme, Markus

“…Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and…”
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Comparing growth patterns of three species: Similarities and differences by Brunner, Norbert, Kühleitner, Manfred, Nowak, Werner Georg, Renner-Martin, Katharina, Scheicher, Klaus

“…Quantitative studies of the growth of dinosaurs have made comparisons with modern animals possible. Therefore, it is meaningful to ask, if extinct dinosaurs…”
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Attempts Directed towards the Synthesis of Intermediate (Aryne)chromium Complexes from Aryl Triflates and from (Haloarene)chromium Complexes by Werner, Georg, Butenschön, Holger

“…The generation of (η6‐aryne)chromium complexes as reactive intermediates was investigated in two ways. Although earlier attempts directed towards triflate…”
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On the exponent in the Von Bertalanffy growth model by Renner-Martin, Katharina, Brunner, Norbert, Kühleitner, Manfred, Nowak, Werner Georg, Scheicher, Klaus

“…Von Bertalanffy proposed the differential equation '( ) =   ×  ( )  -   ×  ( ) for the description of the mass growth of animals as a function ( ) of time . He…”
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Depletion and activation of microglia impact metabolic connectivity of the mouse brain by Gnörich, Johannes, Reifschneider, Anika, Wind, Karin, Zatcepin, Artem, Kunte, Sebastian T, Beumers, Philipp, Bartos, Laura M, Wiedemann, Thomas, Grosch, Maximilian, Xiang, Xianyuan, Fard, Maryam K, Ruch, Francois, Werner, Georg, Koehler, Mara, Slemann, Luna, Hummel, Selina, Briel, Nils, Blume, Tanja, Shi, Yuan, Biechele, Gloria, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bartenstein, Peter, Albert, Nathalie L, Herms, Jochen, Tahirovic, Sabina, Haass, Christian, Capell, Anja, Ziegler, Sibylle, Brendel, Matthias

“…We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine…”
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Optimal and near-optimal exponent-pairs for the Bertalanffy-Pütter growth model by Renner-Martin, Katharina, Brunner, Norbert, Kühleitner, Manfred, Nowak, Werner-Georg, Scheicher, Klaus

“…The Bertalanffy-Pütter growth model describes mass at age by means of the differential equation d /d = * m  -  * . The special case using the von Bertalanffy…”
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Fluorescence optical imaging and musculoskeletal ultrasonography in juvenile idiopathic polyarticular disease before and during antirheumatic treatment - a multicenter non-interventional diagnostic evaluation by Klein, Ariane, Just, Georg Werner, Werner, Stephanie Gabriele, Oommen, Prasad T, Minden, Kirsten, Becker, Ingrid, Langer, Hans-Eckhard, Klee, Dirk, Horneff, Gerd

“…Valid detection of inflamed joints is essential for correct classification, therapeutic decisions, prognosis and assessment of treatment efficacy in juvenile…”
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The First Anionic Thia-Fries Rearrangements at Ferrocene: Ready Access to Trifluoromethylsulfonyl-Substituted Hydroxyferrocenes and an Extremely High Interannular Stereoinduction between Cyclopentadienyl Ligands by Werner, Georg, Lehmann, Christian W., Butenschön, Holger

“…Attempts originally directed towards the generation of ferrocyne (1,2‐dehydroferrocene, 4) and ferrocenediyne (1,2,1′,2′‐tetradehydroferrocene, 5) by triflate…”
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