Search Results - "Werdich, A."

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes by Kikuchi, Kazu, Holdway, Jennifer E., Werdich, Andreas A., Anderson, Ryan M., Fang, Yi, Egnaczyk, Gregory F., Evans, Todd, MacRae, Calum A., Stainier, Didier Y. R., Poss, Kenneth D.

“…Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is…”
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Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture by Feinberg, Adam W, Alford, Patrick W, Jin, Hongwei, Ripplinger, Crystal M, Werdich, Andreas A, Sheehy, Sean P, Grosberg, Anna, Parker, Kevin Kit

“…Abstract The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascular networks, collagen fibrils, fibroblasts, and…”
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Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy by Arndt, Anne-Karin, Schafer, Sebastian, Drenckhahn, Jorg-Detlef, Sabeh, M. Khaled, Plovie, Eva R., Caliebe, Almuth, Klopocki, Eva, Musso, Gabriel, Werdich, Andreas A., Kalwa, Hermann, Heinig, Matthias, Padera, Robert F., Wassilew, Katharina, Bluhm, Julia, Harnack, Christine, Martitz, Janine, Barton, Paul J., Greutmann, Matthias, Berger, Felix, Hubner, Norbert, Siebert, Reiner, Kramer, Hans-Heiner, Cook, Stuart A., MacRae, Calum A., Klaassen, Sabine

“…Deletion 1p36 syndrome is recognized as the most common terminal deletion syndrome. Here, we describe the loss of a gene within the deletion that is…”
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Rapid behavior-based identification of neuroactive small molecules in the zebrafish by Kokel, David, Peterson, Randall T, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J, Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A, Haggarty, Stephen J, MacRae, Calum A, Shoichet, Brian

“…Despite the need for new psychoactive drugs, there are few robust approaches for discovering novel neuroactive molecules. Development of a behavior-based…”
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The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion by Wang, Jinhu, Panáková, Daniela, Kikuchi, Kazu, Holdway, Jennifer E, Gemberling, Matthew, Burris, James S, Singh, Sumeet Pal, Dickson, Amy L, Lin, Yi-Fan, Sabeh, M Khaled, Werdich, Andreas A, Yelon, Deborah, Macrae, Calum A, Poss, Kenneth D

“…Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in…”
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Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel by Panáková, Daniela, Werdich, Andreas A., MacRae, Calum A.

“…Signalling cardiac currents Many important biological processes, including the normal functioning of the heart, require an electrical gradient. The mechanisms…”
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Chamber identity programs drive early functional partitioning of the heart by Mosimann, Christian, Panáková, Daniela, Werdich, Andreas A., Musso, Gabriel, Burger, Alexa, Lawson, Katy L., Carr, Logan A., Nevis, Kathleen R., Sabeh, M. Khaled, Zhou, Yi, Davidson, Alan J., DiBiase, Anthony, Burns, Caroline E., Burns, C. Geoffrey, MacRae, Calum A., Zon, Leonard I.

“…The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and expands by adding second heart field (SHF) cells. While both lineages…”
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An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes by McPheeters, Matthew T, Wang, Yves T, Werdich, Andreas A, Jenkins, Michael W, Laurita, Kenneth R

“…Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however,…”
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Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations by Zhang, Kun, Yuan, Guanxiang, Werdich, Andreas A., Zhao, Yanbin

“…The non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen and diclofenac are highly prescribed worldwide and their presence in aquatic system may pose a…”
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Differential pH measurements of metabolic cellular activity in nl culture volumes using microfabricated iridium oxide electrodes by Ges, Igor A., Ivanov, Borislav L., Werdich, Andreas A., Baudenbacher, Franz J.

“…In this paper we describe a new approach to measure pH differences in microfluidic devices and demonstrated acidification rate measurements in on-chip cell…”
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Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish by Becker, Jason R, Deo, Rahul C, Werdich, Andreas A, Panàkovà, Daniela, Coy, Shannon, MacRae, Calum A

“…To assess the effects during cardiac development of mutations that cause human cardiomyopathy, we modeled a sarcomeric gene mutation in the embryonic…”
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Thin-film IrOx pH microelectrode for microfluidic-based microsystems by GES, Igor A, IVANOV, Borislav L, SCHAFFER, David K, LIMA, Eduardo A, WERDICH, Andreas A, BAUDENBACHER, Franz J

“…Microsensors are valuable tools to monitor cell metabolism in cell culture volumes. The present research describes the fabrication and characterization of…”
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Rapid Zebrafish Behavioral Profiling Assay Accelerates the Identification of Environmental Neurodevelopmental Toxicants by Zhang, Kun, Liang, Jiahui, Brun, Nadja R, Zhao, Yanbin, Werdich, Andreas A

“…Rapid and cost-effective in vivo assays to screen potential environmental neurodevelopmental toxicants are necessary to address the limitations of in vitro…”
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Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk by Nikolova-Krstevski, Vesna, PhD, Wagner, Soeren, MD, Yu, Ze Yan, MD, Cox, Charles D., PhD, Cvetkovska, Jasmina, BSc, Hill, Adam P., PhD, Huttner, Inken G., MD, Benson, Victoria, PhD, Werdich, Andreas A., PhD, MacRae, Calum, MD, PhD, Feneley, Michael P., MD, PhD, Friedrich, Oliver, PhD, Martinac, Boris, PhD, Fatkin, Diane, MD

“…Visual Abstract…”
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Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel by Panáková, Daniela, Werdich, Andreas A, Macrae, Calum A

“…Electrical gradients are critical for many biological processes, including the normal function of excitable tissues, left-right patterning, organogenesis and…”
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A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings by Werdich, Andreas A, Lima, Eduardo A, Ivanov, Borislav, Ges, Igor, Anderson, Mark E, Wikswo, John P, Baudenbacher, Franz J

“…A hybrid chip is described which combines a microfluidic network fabricated in a silicone elastomer (PDMS) with planar microelectrodes. It was used to measure…”
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Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish by Wythe, Joshua D, Jurynec, Michael J, Urness, Lisa D, Jones, Christopher A, Sabeh, M Khaled, Werdich, Andreas A, Sato, Mariko, Yost, H Joseph, Grunwald, David J, Macrae, Calum A, Li, Dean Y

“…The vertebrate heart is one of the first organs to form, and its early function and morphogenesis are crucial for continued embryonic development. Here we…”
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Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation by Ghazizadeh, Zaniar, Kiviniemi, Tuomas, Olafsson, Sigurast, Plotnick, David, Beerens, Manu E., Zhang, Kun, Gillon, Leah, Steinbaugh, Michael J., Barrera, Victor, Sui, Shannan Ho, Werdich, Andreas A., Kapur, Sunil, Eranti, Antti, Gunn, Jarmo, Jalkanen, Juho, Airaksinen, Juhani, Kleber, Andre G., Hollmén, Maija, MacRae, Calum A.

“…BACKGROUND:Atrial fibrillation (AF) is the most common clinical arrhythmia and is associated with heart failure, stroke, and increased mortality. The…”
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Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice by Werdich, Andreas A, Baudenbacher, Franz, Dzhura, Igor, Jeyakumar, Loice H, Kannankeril, Prince J, Fleischer, Sidney, LeGrone, Alison, Milatovic, Dejan, Aschner, Michael, Strauss, Arnold W, Anderson, Mark E, Exil, Vernat J

“…Patients with mutations in the mitochondrial very-long-chain acyl-CoA dehydrogenase (VLCAD) gene are at risk for cardiomyopathy, myocardial dysfunction,…”
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Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression by Colombo, Sophie, de Sena-Tomás, Carmen, George, Vanessa, Werdich, Andreas A, Kapur, Sunil, MacRae, Calum A, Targoff, Kimara L

“…is the most commonly mutated gene associated with human congenital heart defects (CHDs), with a predilection for cardiac pole abnormalities. This homeodomain…”
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