Search Results - "Wentworth, Paul"

3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy by Luik, Philipp, Chew, Chee, Aittoniemi, Jussi, Chang, Jason, Wentworth, Paul Jr, Dwek, Raymond A, Biggin, Philip C, Vénien-Bryan, Catherine, Zitzmann, Nicole

“…Infection with the hepatitis C virus (HCV) has a huge impact on global health putting more than 170 million people at risk of developing severe liver disease…”
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A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins by Prapainop, Kanlaya, Witter, Daniel P, Wentworth, Paul

“…A major challenge in nanomaterial science is to develop approaches that ensure that when administered in vivo, nanoparticles can be targeted to their requisite…”
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Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation by Wentworth, Paul, McDunn, Jonathan E., Wentworth, Anita D., Takeuchi, Cindy, Nieva, Jorge, Jones, Teresa, Bautista, Cristina, Ruedi, Julie M., Gutierrez, Abel, Janda, Kim D., Babior, Bernard M., Eschenmoser, Albert, Lerner, Richard A.

“…Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen ($^{1}O_{2}^*$) and water. Here, we show…”
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Evidence for Ozone Formation in Human Atherosclerotic Arteries by Wentworth, Paul, Nieva, Jorge, Takeuchi, Cindy, Galve, Roger, Wentworth, Anita D., Dilley, Ralph B., DeLaria, Giacomo A., Saven, Alan, Babior, Bernard M., Janda, Kim D., Eschenmoser, Albert, Lerner, Richard A.

“…Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic…”
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Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization by Kelly, Jeffery W, Bosco, Daryl A, Fowler, Douglas M, Zhang, Qinghai, Nieva, Jorge, Powers, Evan T, Wentworth, Paul, Lerner, Richard A

“…Oxidative stress, inflammation and α-synuclein overexpression confer risk for development of α-synucleinopathies-neurodegenerative diseases that include…”
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Investigating Antibody-Catalyzed Ozone Generation by Human Neutrophils by Babior, Bernard M., Takeuchi, Cindy, Ruedi, Julie, Gutierrez, Abel, Wentworth, Paul

“…Recent studies have suggested that antibodies can catalyze the generation of previously unknown oxidants including dihydrogen trioxide (H2O3) and ozone (O3)…”
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Metabolite-Initiated Protein Misfolding May Trigger Alzheimer's Disease by Zhang, Qinghai, Powers, Evan T., Nieva, Jorge, Huff, Mary E., Dendle, Maria A., Bieschke, Jan, Glabe, Charles G., Eschenmoser, Albert, Wentworth, Paul, Lerner, Richard A., Kelly, Jeffery W.

“…Anfinsen showed that a protein's fold is specified by its sequence. Although it is clear why mutant proteins form amyloid, it is harder to rationalize why a…”
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Reduction of Ischemia and Reperfusion-Induced Myocardial Damage by Cytochrome P450 Inhibitors by Granville, David J., Tashakkor, Babak, Takeuchi, Cindy, Gustafsson, Åsa B., Huang, Chengqun, Sayen, M. Richard, Wentworth, Paul, Yeager, Mark, Gottlieb, Roberta A.

“…Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when…”
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Antibody Catalysis of the Oxidation of Water by Wentworth, Paul, Jones, Lyn H., Wentworth, Anita D., Zhu, Xueyong, Larsen, Nicholas A., Wilson, Ian A., Xu, Xin, Goddard, William A., Janda, Kim D., Eschenmoser, Albert, Lerner, Richard A.

“…Recently we reported that antibodies can generate hydrogen peroxide (H2O 2) from singlet molecular oxygen (1O 2 *). We now show that this process is catalytic,…”
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Adduction of Cholesterol 5,6-Secosterol Aldehyde to Membrane-Bound Myelin Basic Protein Exposes an Immunodominant Epitope by Cygan, Natalie K, Scheinost, Johanna C, Butters, Terry D, Wentworth, Paul

“…Myelin degradation in the central nervous system (CNS) is a clinical hallmark of multiple sclerosis (MS). A reduction in the net positive charge of myelin…”
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Small Molecule Oxidation Products Trigger Disease-Associated Protein Misfolding by Bieschke, Jan, Zhang, Qinghai, Bosco, Daryl A, Lerner, Richard A, Powers, Evan T, Wentworth, Paul, Kelly, Jeffery W

“…Oxidative stress and inflammation are risk factors for both the development of α-synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies,…”
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The antibody-catalyzed water oxidation pathway – a new chemical arm to immune defense? by Nieva, Jorge, Wentworth, Paul

“…Antibodies are the classical adaptor molecules of the immune system, linking recognition and killing of foreign pathogens. However, the recent discovery of a…”
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Evidence for the Production of Trioxygen Species during Antibody-Catalyzed Chemical Modification of Antigens by Wentworth, Paul, Wentworth, Anita D., Zhu, Xueyong, Wilson, Ian A., Janda, Kim D., Eschenmoser, Albert, Lerner, Richard A.

“…Recent work in our laboratory showed that products formed by the antibody-catalyzed water-oxidation pathway can kill bacteria. Dihydrogen peroxide, the end…”
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A shotgun proteomic study of the protein corona associated with cholesterol and atheronal-B surface-modified quantum dots by Prapainop, Kanlaya, Wentworth, Paul

“…The corona of sterol and oxysterol-coated quantum dots is rich in lipoproteins and their composite proteomes. As part of ongoing research in our group, we are…”
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Antibodies Have the Intrinsic Capacity to Destroy Antigens by Wentworth, Anita D., Jones, Lyn H., Wentworth, Paul, Janda, Kim D., Lerner, Richard A.

“…Research throughout the last century has led to a consensus as to the strategy of the humoral component of the immune system. The essence is that, for killing,…”
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The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo by Wentworth, Anita D, Song, Byeong-Doo, Nieva, Jorge, Shafton, Asher, Tripurenani, Sangeetha, Wentworth, Jr, Paul

“…Ongoing efforts to unravel the origins of the cholesterol 5,6-secosterols (1a and 1b) in biological systems have revealed that the two known chemical routes to…”
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Cholesterol seco-Sterol-Induced Aggregation of Methylated Amyloid-β Peptides--Insights into Aldehyde-Initiated Fibrillization of Amyloid-β by Scheinost, Johanna C, Wang, Hong, Boldt, Grant E, Offer, John, Wentworth, Paul Jr

“…Hot spot on amyloid‐β? Atheronal‐B‐induced aggregation of amyloid‐β (Aβ) involves a site‐specific adduction of the aldehyde to the ε‐amino group of Lys 16,…”
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Synthetic 1-Deoxynojirimycin N-Substituted Peptides Offer Prolonged Disruption to N-Linked Glycan Processing by Aguilar, Aimé López, Escribano, Jaime, Wentworth Jr, Paul, Butters, Terry D.

“…A panel of 1‐deoxynojirimycin (DNJ) N‐linked peptides were synthesized. Their IC50 values were measured in vitro against α‐glucosidases I and II and were found…”
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Cholesterol Secosterol Adduction Inhibits the Misfolding of a Mutant Prion Protein Fragment that Induces Neurodegeneration by Scheinost, Johanna C, Witter, Daniel P, Boldt, Grant E, Offer, John, Wentworth, Paul Jr

“…Aldehyde is critical: Atheronal‐B, a cholesterol secosterol aldehyde (see structure), completely inhibits the misfolding of a prion protein fragment from its α…”
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Total Synthesis of the Depsipeptide FR-901375 by Chen, Yanping, Gambs, Celine, Abe, Yoshito, Wentworth, Paul, Janda, Kim D

“…The first total synthesis of FR-901375, a novel bicyclic depsipeptide isolated from the fermentation broth of Pseudomonas chloroaphis No. 2522, has been…”
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