Search Results - "Wentland, M P"

Selective protection and functionalization of morphine: Synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives by WENTLAND, Mark P, WENHU DUAN, COHEN, Dana J, BIDLACK, Jean M

“…As part of an effort to identify novel opioid receptor interactive agents, we recently prepared a series of 8-(substituted)amino analogues of cyclazocine. We…”
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8-aminocyclazocine analogues : Synthesis and structure-activity relationships by WENTLAND, M. P, GUOYOU XU, CIOFFI, C. L, YINGCHUN YE, WENHU DUAN, COHEN, D. J, COLASURDO, A. M, BIDLACK, J. M

“…Opioid binding affinities were assessed for a series of cyclazocine analogues where the prototypic 8-OH substituent of cyclazocine was replaced by amino and…”
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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by COUGHLIN, S. A, DANZ, D. W, RAKE, J. B, ROBINSON, R. G, KLINGBEIL, K. M, WENTLAND, M. P, CORBETT, T. H, WAUD, W. R, ZWELLING, L. A, ALTSCHULER, E, BALES, E

“…(S)-10-(2,6-Dimethyl-4-pyridinyl) 9-fluoro-3-methyl-7-oxo 2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives by Perni, Robert B, Wentland, Mark P, Huang, Jianhua I, Powles, Ronald G, Aldous, Suzanne, Klingbeil, Kristina M, Peverly, A. Danielle, Robinson, Ronald G, Corbett, Thomas H, Jones, Julie L, Mattes, Kenneth C, Rake, James B, Coughlin, Susan A

“…Two new series of antitumor agents, 4-aminomethylthioxanthenones (6 − 50) and 5-aminomethylbenzothiopyranoindazoles (51 − 61), are described and compared…”
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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
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3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Brundage, R. Pauline, Castaldi, Michael J, Bailey, Thomas R, Carabateas, Philip M, Bacon, Edward R, Young, Dorothy C

“…A series of novel 3-quinolinecarboxamides that are structurally similar to the quinolone class of antibacterial agents possess excellent antiherpetic…”
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Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity by Wentland, Mark P, Carlson, John A, Dorff, Peter H, Aldous, Suzanne C, Perni, Robert B, Young, Dorothy C, Woods, Maureen G, Kingsley, Susan D, Ryan, Kathryn A, Rosi, David, Drozd, Marion L, Dutko, Frank J

“…Supported by the antiherpetic properties of 3-quinolinecarboxamides and the importance of the planar intramolecular H-bonded beta-keto amide pharmacophore, a…”
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8-Carboxamidocyclazocine analogues: redefining the structure–activity relationships of 2,6-methano-3-benzazocines by Wentland, Mark P., Lou, Rongliang, Ye, Yingchun, Cohen, Dana J., Richardson, Gregory P., Bidlack, Jean M.

“…Unexpectedly high affinity for opioid receptors has been observed for a novel series of cyclazocine analogues where the prototypic 8-OH was replaced by a…”
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In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin) by CORNETT, J. B, WAGNER, R. B, DOBSON, R. A, WENTLAND, M. P, BAILEY, D. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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DNA sequence preferences at sites cleaved by human DNA topoisomerase II in response to novel quinolone derivatives by Huff, A C, Robinson, R G, Evans, A C, Selander, K N, Wentland, M P, Rake, J B, Coughlin, S A

“…We have examined the DNA cleavage site specificity of human type II DNA topoisomerase in the presence of each of five novel quinolone derivatives. Each…”
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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Rake, James B

“…A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared…”
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Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships by Wentland, Mark P, Bailey, Denis M, Cornett, James B, Dobson, Richard A, Powles, Ronald G, Wagner, Roland B

“…A series of novel 3-quinolinecarboxylic acid derivatives have been prepared and their antibacterial activity evaluated. These derivatives are characterized by…”
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3-Carboxamido analogues of morphine and naltrexone: synthesis and opioid receptor binding properties by Wentland, Mark P., Lou, Rongliang, Dehnhardt, Christoph M., Duan, Wenhu, Cohen, Dana J., Bidlack, Jean M.

“…In response to the unexpectedly high affinity for opioid receptors observed in a novel series of cyclazocine analogues where the prototypic 8-OH was replaced…”
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Partial Opioids: Medications for the Treatment of Pain and Drug Abuse by BIDLACK, JEAN M., McLAUGHLIN, JAY P., WENTLAND, MARK P.

“…: Pentazocine and cyclazocine are two benzomorphans that were synthesized by the late Sydney Archer in 1962. These benzomorphans were synthesized as part of an…”
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Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives by Wentland, Mark P, Bailey, Denis M, Alexander, E. John, Castaldi, Michael J, Ferrari, Richard A, Haubrich, Dean R, Luttinger, Daniel A, Perrone, Mark H

“…A unique combination of alpha 2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of…”
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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives by Wentland, Mark P, Lesher, George Y, Reuman, Michael, Gruett, Monte D, Singh, Baldev, Aldous, Suzanne C, Dorff, Peter H, Rake, James B, Coughlin, Susan A

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Arylacetamide kappa-selective opioid ligands by Pechulis, Anthony D., Archer, Sydney, Wentland, Mark P., Colasurdo, Ann M., Bidlack, Jean M.

“…A family of arylacetamide opioid ligands was prepared. Competition binding studies indicate that in each case the ( S)-(+) series was two orders of magnitude…”
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In vitro dental plaque inhibitory properties of a series of N-[1-alkyl-4(1H)-pyridinylidene]alkylamines by Wentland, Mark P, Bailey, Denis M, Powles, Ronald G, Slee, Andrew M, Sedlock, David M

“…A series of novel N-[1-alkyl-4(1H)-pyridinylidene]alkylamine hydrohalides has been prepared and evaluated as inhibitors of dental plaque formation, in vitro…”
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Synthesis of aza-macrocycles from polycyclic 5-aminoisoxazoline precursors by Wentland, Mark P, Kullnig, Rudolph K, Tham, Fook S

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Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling by Ding, Xinxin, Hough, Lindsay B, Conroy, Jennie L, Fang, Cheng, Gu, Jun, Zeitlin, Scott O, Yang, Weizhu, Yang, Jun, VanAlstine, Melissa A, Nalwalk, Julia W, Albrecht, Phillip J, Mazurkiewicz, Joseph E, Snyder-Keller, Abigail, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Behr, Melissa, Knapp, Brian I, Bidlack, Jean M, Zuiderveld, Obbe P, Leurs, Rob

“…To assess the importance of brain cytochrome P450 (P450) activity in μ opioid analgesic action, we generated a mutant mouse with brain neuron-specific…”
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