Search Results - "Wensveen, Felix"

NKG2D: A Master Regulator of Immune Cell Responsiveness by Wensveen, Felix M, Jelenčić, Vedrana, Polić, Bojan

“…NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune system. Ligands of NKG2D are normally of low abundance,…”
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The “Big Bang” in obese fat: Events initiating obesity‐induced adipose tissue inflammation by Wensveen, Felix M., Valentić, Sonja, Šestan, Marko, Turk Wensveen, Tamara, Polić, Bojan

“…Obesity is associated with the accumulation of pro‐inflammatory cells in visceral adipose tissue (VAT), which is an important underlying cause of insulin…”
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Nonalcoholic fatty liver disease-A multisystem disease? by Mikolasevic, Ivana, Milic, Sandra, Turk Wensveen, Tamara, Grgic, Ivana, Jakopcic, Ivan, Stimac, Davor, Wensveen, Felix, Orlic, Lidija

“…Non-alcoholic fatty liver disease(NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome(Met S). Importantly, NAFLD…”
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Type 2 diabetes and viral infection; cause and effect of disease by Turk Wensveen, Tamara, Gašparini, Dora, Rahelić, Dario, Wensveen, Felix M.

“…The recent pandemic of COVID-19 has made abundantly clear that Type 2 diabetes (T2D) increases the risk of more frequent and more severe viral infections. At…”
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NK cells link obesity-induced adipose stress to inflammation and insulin resistance by Wensveen, Felix M, Jelenčić, Vedrana, Valentić, Sonja, Šestan, Marko, Wensveen, Tamara Turk, Theurich, Sebastian, Glasner, Ariella, Mendrila, Davor, Štimac, Davor, Wunderlich, F Thomas, Brüning, Jens C, Mandelboim, Ofer, Polić, Bojan

“…Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polić and colleagues show that VAT NK cells sense obesity-induced adipose…”
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Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration by Gašparini, Dora, Wensveen, Felix M., Turk Wensveen, Tamara

“…•Type 2 diabetes is associated with increased tumor necrosis factor-α by CD8 T cells.•Increased granzyme B production by natural killer cells and γδ T cells is…”
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Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity by Šestan, Marko, Marinović, Sonja, Kavazović, Inga, Cekinović, Đurđica, Wueest, Stephan, Turk Wensveen, Tamara, Brizić, Ilija, Jonjić, Stipan, Konrad, Daniel, Wensveen, Felix M., Polić, Bojan

“…Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is…”
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Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness by Imširović, Vanna, Lenartić, Maja, Wensveen, Felix M, Polić, Bojan, Jelenčić, Vedrana

“…Natural killer (NK) cells play an important role in the early defense against tumors and virally infected cells. Their function is thought to be controlled by…”
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The “Domino effect” in MASLD: The inflammatory cascade of steatohepatitis by Mladenić, Karlo, Lenartić, Maja, Marinović, Sonja, Polić, Bojan, Wensveen, Felix M.

“…Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly common complication of obesity, affecting over a quarter of the global…”
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The immunology of sickness metabolism by Wensveen, Felix M., Šestan, Marko, Polić, Bojan

“…Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are a part of a…”
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Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity by Kavazović, Inga, Han, Hongya, Balzaretti, Giulia, Slinger, Erik, Lemmermann, Niels A W, Ten Brinke, Anja, Merkler, Doron, Koster, Jan, Bryceson, Yenan T, de Vries, Niek, Jonjić, Stipan, Klarenbeek, Paul L, Polić, Bojan, Eldering, Eric, Wensveen, Felix M

“…The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it…”
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Immunological Mechanisms of Sickness Behavior in Viral Infection by Krapić, Mia, Kavazović, Inga, Wensveen, Felix M

“…Sickness behavior is the common denominator for a plethora of changes in normal behavioral routines and systemic metabolism during an infection. Typical…”
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Regulation of immune cell function and differentiation by the NKG2D receptor by Zafirova, Biljana, Wensveen, Felix M., Gulin, Maja, Polić, Bojan

“…NKG2D is one of the most intensively studied immune receptors of the past decade. Its unique binding and signaling properties, expression pattern, and…”
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‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection by Wensveen, Felix M., Šestan, Marko, Turk Wensveen, Tamara, Polić, Bojan

“…The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system…”
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Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development by Jelenčić, Vedrana, Šestan, Marko, Kavazović, Inga, Lenartić, Maja, Marinović, Sonja, Holmes, Tim D., Prchal-Murphy, Michaela, Lisnić, Berislav, Sexl, Veronika, Bryceson, Yenan T., Wensveen, Felix M., Polić, Bojan

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Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction by Kavazović, Inga, Krapić, Mia, Beumer-Chuwonpad, Ammarina, Polić, Bojan, Turk Wensveen, Tamara, Lemmermann, Niels A, van Gisbergen, Klaas P J M, Wensveen, Felix M

“…Type 2 diabetes (T2D) causes an increased risk of morbidity and mortality in response to viral infection. T2D is characterized by hyperglycemia and is…”
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The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8 + T Cell Responses of Low Antigen Affinity to Protect against Viral Variants by van Gisbergen, Klaas P.J.M., Klarenbeek, Paul L., Kragten, Natasja A.M., Unger, Peter-Paul A., Nieuwenhuis, Marieke B.B., Wensveen, Felix M., ten Brinke, Anja, Tak, Paul P., Eldering, Eric, Nolte, Martijn A., van Lier, Rene A.W.

“…CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8 + T cells. Here, we show that CD27-driven…”
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Interactions between adipose tissue and the immune system in health and malnutrition by Wensveen, Felix M, Valentić, Sonja, Šestan, Marko, Turk Wensveen, Tamara, Polić, Bojan

“…Highlights • Adipose tissue is the primary sensor of nutrient availability in the milieu of an organism. • Adipose tissue communicates the metabolic state of…”
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NKG2D: A versatile player in the immune system by Jelenčić, Vedrana, Lenartić, Maja, Wensveen, Felix M, Polić, Bojan

“…Highlights • NKG2D can induce direct killing of target cells expressing its ligands, which are stress-induced. • NKG2D is expressed in hematopoietic precursors…”
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NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development by Jelenčić, Vedrana, Šestan, Marko, Kavazović, Inga, Lenartić, Maja, Marinović, Sonja, Holmes, Tim D., Prchal-Murphy, Michaela, Lisnić, Berislav, Sexl, Veronika, Bryceson, Yenan T., Wensveen, Felix M., Polić, Bojan

“…The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold…”
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