Search Results - "Wensing, Annemarie M. J"

Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis by Messiaen, Peter, Wensing, Annemarie M J, Fun, Axel, Nijhuis, Monique, Brusselaers, Nele, Vandekerckhove, Linos

“…Optimal regimen choice of antiretroviral therapy is essential to achieve long-term clinical success. Integrase inhibitors have swiftly been adopted as part of…”
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Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review by Barth, Roos E, Dr, van der Loeff, Maarten F Schim, MD, Schuurman, Rob, PhD, Hoepelman, Andy IM, MD, Wensing, Annemarie MJ, MD

“…Summary Following large-scale roll-out of antiretroviral therapy in sub-Saharan Africa, the non-clinical efficacy of antiretroviral therapy has received little…”
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Human Immunodeficiency Virus Gag and protease: partners in resistance by Fun, Axel, Wensing, Annemarie M J, Verheyen, Jens, Nijhuis, Monique

“…Human Immunodeficiency Virus (HIV) maturation plays an essential role in the viral life cycle by enabling the generation of mature infectious virus particles…”
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HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing by Rhee, Soo-Yon, Jordan, Michael R, Raizes, Elliot, Chua, Arlene, Parkin, Neil, Kantor, Rami, Van Zyl, Gert U, Mukui, Irene, Hosseinipour, Mina C, Frenkel, Lisa M, Ndembi, Nicaise, Hamers, Raph L, Rinke de Wit, Tobias F, Wallis, Carole L, Gupta, Ravindra K, Fokam, Joseph, Zeh, Clement, Schapiro, Jonathan M, Carmona, Sergio, Katzenstein, David, Tang, Michele, Aghokeng, Avelin F, De Oliveira, Tulio, Wensing, Annemarie M J, Gallant, Joel E, Wainberg, Mark A, Richman, Douglas D, Fitzgibbon, Joseph E, Schito, Marco, Bertagnolio, Silvia, Yang, Chunfu, Shafer, Robert W

“…The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and…”
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Transmission of Drug-Resistant HIV-1 Is Stabilizing in Europe by Vercauteren, Jurgen, Wensing, Annemarie M. J., van de Vijver, David A. M. C., Albert, Jan, Balotta, Claudia, Hamouda, Osamah, Kücherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Åsjö, Birgitta, Bruckova, Marie, Camacho, Ricardo J., Clotet, Bonaventura, Coughlan, Suzie, Grossman, Zehava, Horban, Andrzej, Korn, Klaus, Kostrikis, Leondios, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Salminen, Mika, Schuurman, Rob, Sonnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Vandamme, Anne-Mieke, Boucher, Charles A. B.

“…The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793…”
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An automated genotyping system for analysis of HIV-1 and other microbial sequences by de Oliveira, Tulio, Deforche, Koen, Cassol, Sharon, Salminen, Mika, Paraskevis, Dimitris, Seebregts, Chris, Snoeck, Joe, van Rensburg, Estrelita Janse, Wensing, Annemarie M. J., van de Vijver, David A., Boucher, Charles A., Camacho, Ricardo, Vandamme, Anne-Mieke

“…Motivation: Genetic analysis of HIV-1 is important not only for vaccine development, but also to guide treatment strategies, track the emergence of new viral…”
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HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation by Gupta, Ravindra K., Abdul-Jawad, Sultan, McCoy, Laura E., Mok, Hoi Ping, Peppa, Dimitra, Salgado, Maria, Martinez-Picado, Javier, Nijhuis, Monique, Wensing, Annemarie M. J., Lee, Helen, Grant, Paul, Nastouli, Eleni, Lambert, Jonathan, Pace, Matthew, Salasc, Fanny, Monit, Christopher, Innes, Andrew J., Muir, Luke, Waters, Laura, Frater, John, Lever, Andrew M. L., Edwards, Simon G., Gabriel, Ian H., Olavarria, Eduardo

“…A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago 1 , 2 . The individual—who is known as the ‘Berlin patient’—underwent…”
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Sustained virological response on second-line antiretroviral therapy following virological failure in HIV-infected patients in rural South Africa by Schoffelen, Annelot F, Wensing, Annemarie M J, Tempelman, Hugo A, Geelen, Sibyl P M, Hoepelman, Andy I M, Barth, Roos E

“…This study aims to describe the virological, immunological and clinical efficacy of protease inhibitor (PI)-based second-line antiretroviral therapy (ART) in…”
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Evolutionary pathways of transmitted drug-resistant HIV-1 by Pingen, Marieke, Nijhuis, Monique, de Bruijn, Johan A., Boucher, Charles A. B., Wensing, Annemarie M. J.

“…Several large studies in Europe and the USA revealed that approximately 10% of all newly diagnosed patients harbour HIV-1 variants with at least one major…”
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Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance by Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I M, Gisolf, Elizabeth H, Schipper, Pauline J, Wensing, Annemarie M J, Nijhuis, Monique

“…Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection…”
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Periodontal inflammation as a potential driver of HIV low level viremia by Stam, Arjen J, Groenewegen, Hester, Vissink, Arjan, Wensing, Annemarie M J, Nijhuis, Monique, Bierman, Wouter F W

“…HIV can be successfully suppressed to undetectable levels by antiretroviral therapy (ART) in most people with HIV (PWH). However, a small proportion continues…”
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Lower Incidence of HIV-1 Blips Observed During Integrase Inhibitor–Based Combination Antiretroviral Therapy by Dijkstra, Suzan, Hofstra, L. Marije, Mudrikova, Tania, Wensing, Annemarie M. J., Oomen, Patrick G. A., Hoepelman, Andy I. M., van Welzen, Berend J.

“…As the nature of viral blips remains unclear, their occurrence often leads to uncertainty. This study compares blip incidence rates during treatment with…”
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High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates by VERHEYEN, Jens, VERHOFSTEDE, Chris, NIJHUIS, Monique, KNOPS, Elena, VANDEKERCKHOVE, Linos, FUN, Axel, BRUNEN, Diede, DAUWE, Kenny, WENSING, Annemarie M. J, PFISTER, Herbert, KAISER, Rolf

“…Bevirimat is the first drug of a new class of antivirals that hamper the maturation of HIV. The objective of this study was to evaluate the sequence…”
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Failure of Treatment with First-Line Lopinavir Boosted with Ritonavir Can Be Explained by Novel Resistance Pathways with Protease Mutation 76V by Nijhuis, Monique, Wensing, Annemarie M. J., Bierman, Wouter F. W., de Jong, Dorien, Kagan, Ron, Fun, Axel, Jaspers, Christian A. J. J., Schurink, Karin A. M., van Agtmael, Michael A., Boucher, Charles A. B.

“…BackgroundVirological failure of first-line antiretroviral therapy based on lopinavir boosted with ritonavir (lopinavir/r) has rarely been associated with…”
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Virological suppression and clinical management in response to viremia in South African HIV treatment program: A multicenter cohort study by Hermans, Lucas E, Carmona, Sergio, Nijhuis, Monique, Tempelman, Hugo A, Richman, Douglas D, Moorhouse, Michelle, Grobbee, Diederick E, Venter, Willem D F, Wensing, Annemarie M J

“…Uptake of antiretroviral treatment (ART) is expanding rapidly in low- and middle-income countries (LMIC). Monitoring of virological suppression is recommended…”
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Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates by Baatz, Franky, Nijhuis, Monique, Lemaire, Morgane, Riedijk, Martiene, Wensing, Annemarie M J, Servais, Jean-Yves, van Ham, Petra M, Hoepelman, Andy I M, Koopmans, Peter P, Sprenger, Herman G, Devaux, Carole, Schmit, Jean-Claude, Perez Bercoff, Danielle

“…Resistance mutations to the HIV-1 fusion inhibitor enfuvirtide emerge mainly within the drug's target region, HR1, and compensatory mutations have been…”
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Presence of occult HBV, but near absence of active HBV and HCV infections in people infected with HIV in rural South Africa by Barth, Roos E., Huijgen, Quirine, Tempelman, Hugo A., Mudrikova, Tania, Wensing, Annemarie M.J., Hoepelman, Andy I.M.

“…Human immunodeficiency (HIV), hepatitis B (HBV), and hepatitis C (HCV) viruses are endemic in Sub‐Saharan Africa, but data regarding the prevalence of…”
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Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids by Gumbs, Stephanie B H, Berdenis van Berlekom, Amber, Kübler, Raphael, Schipper, Pauline J, Gharu, Lavina, Boks, Marco P, Ormel, Paul R, Wensing, Annemarie M J, de Witte, Lot D, Nijhuis, Monique

“…The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central…”
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Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance by Wensing, Annemarie M.J., van Maarseveen, Noortje M., Nijhuis, Monique

“…HIV protease plays a crucial role in the viral life cycle and is essential for the generation of mature infectious virus particles. Detailed knowledge of the…”
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Continuous intravenous infusion of enfuvirtide in a patient with a multidrug-resistant HIV strain by Neijzen, Robert W., Van Maarseveen, Erik M., Hoepelman, Andy I. M., Wensing, Annemarie M. J., Bonora, Stefano, D’Avolio, Antonio, Mudrikova, Tania

“…Case description To evaluate whether continuous intravenous (i.v.) administration of enfuvirtide (T20) could be a suitable alternative to subcutaneous (s.c.)…”
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