Search Results - "Wennström, Malin"

Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals by Schultz, Nina, Byman, Elin, Wennström, Malin

“…Previous studies have used immunohistology to demonstrate Alzheimer's disease (AD) characteristic accumulation of amyloid-β (Aβ) in the retina of AD patients,…”
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Amylin alters human brain pericyte viability and NG2 expression by Schultz, Nina, Byman, Elin, Fex, Malin, Wennström, Malin

“…Amylin, a pancreatic β-cell-derived peptide hormone, forms inclusions in brain microvessels of patients with dementia who have been diagnosed with type 2…”
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Okinawa-Based Nordic Diet Decreases Plasma Glial Fibrillary Acidic Protein Levels in Type 2 Diabetes Patients by Pocevičiūtė, Dovilė, Wennström, Malin, Ohlsson, Bodil

“…Elevated levels of glial fibrillary acidic protein (GFAP) in plasma reflect neuroinflammation and are linked to cognitive decline. Preclinical studies show…”
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Okinawa-Based Nordic Diet Decreases Plasma Levels of IAPP and IgA against IAPP Oligomers in Type 2 Diabetes Patients by Pocevičiūtė, Dovilė, Roth, Bodil, Ohlsson, Bodil, Wennström, Malin

“…Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to…”
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Levels of retinal IAPP are altered in Alzheimer's disease patients and correlate with vascular changes and hippocampal IAPP levels by Schultz, Nina, Byman, Elin, Wennström, Malin

“…Islet amyloid polypeptide (IAPP) forms toxic aggregates in the brain of patients with Alzheimer's disease (AD). Whether IAPP also affects the retina in these…”
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Increased blood-brain barrier permeability is associated with dementia and diabetes, but not amyloid pathology or APOE genotype by Janelidze, Shorena, PhD, Hertze, Joakim, MD, PhD, Nägga, Katarina, MD, PhD, Nilsson, Karin, Nilsson, Christer, MD, PhD, Wennström, Malin, PhD, van Westen, Danielle, MD, PhD, Blennow, Kaj, MD, PhD, Zetterberg, Henrik, MD, PhD, Hansson, Oskar, MD, PhD

“…Abstract Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in…”
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Brain alpha‐amylase: a novel energy regulator important in Alzheimer disease? by Byman, Elin, Schultz, Nina, Fex, Malin, Wennström, Malin

“…Reduced glucose metabolism and formation of polyglucosan bodies (PGB) are, beside amyloid beta plaques and neurofibrillary tangles, well‐known pathological…”
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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease by Boza-Serrano, Antonio, Ruiz, Rocío, Sanchez-Varo, Raquel, García-Revilla, Juan, Yang, Yiyi, Jimenez-Ferrer, Itzia, Paulus, Agnes, Wennström, Malin, Vilalta, Anna, Allendorf, David, Davila, Jose Carlos, Stegmayr, John, Jiménez, Sebastian, Roca-Ceballos, Maria A., Navarro-Garrido, Victoria, Swanberg, Maria, Hsieh, Christine L., Real, Luis M., Englund, Elisabet, Linse, Sara, Leffler, Hakon, Nilsson, Ulf J., Brown, Guy C., Gutierrez, Antonia, Vitorica, Javier, Venero, Jose Luis, Deierborg, Tomas

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary…”
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NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells by Rippe, Catarina, Morén, Björn, Liu, Li, Stenkula, Karin G., Mustaniemi, Johan, Wennström, Malin, Swärd, Karl

“…The present work addressed the hypothesis that NG2/ CSPG4 , CD146/ MCAM , and VAP1/ AOC3 are target genes of myocardin-related transcription factors (MRTFs:…”
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NG2-glia: rising stars in stress-related mental disorders? by Poggi, G., Wennström, Malin, Müller, M. B., Treccani, G.

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Neuronal α‐amylase is important for neuronal activity and glycogenolysis and reduces in presence of amyloid beta pathology by Byman, Elin, Martinsson, Isak, Haukedal, Henriette, Gouras, Gunnar, Freude, Kristine K., Wennström, Malin

“…Recent studies indicate a crucial role for neuronal glycogen storage and degradation in memory formation. We have previously identified alpha‐amylase…”
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Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy by Wennström, Malin, Surova, Yulia, Hall, Sara, Nilsson, Christer, Minthon, Lennart, Boström, Fredrik, Hansson, Oskar, Nielsen, Henrietta M

“…Neurosin is a protease that in vitro degrades α-synuclein, the main constituent of Lewy bodies found in brains of patients with synucleinopathy including…”
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Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2 by Schultz, Nina, Nielsen, Henrietta M, Minthon, Lennart, Wennström, Malin

“…ABSTRACTDeposition of amyloid-β (Aβ) 1–42, the major component of senile plaques characteristic of Alzheimer disease, affects brain microvascular integrity and…”
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Increased levels of hyaluronic acid in cerebrospinal fluid in patients with vascular dementia by Nägga, Katarina, Hansson, Oskar, van Westen, Danielle, Minthon, Lennart, Wennström, Malin

“…Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been…”
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Pro-inflammatory cytokines reduce the proliferation of NG2 cells and increase shedding of NG2 in vivo and in vitro by Wennström, Malin, Janelidze, Shorena, Bay-Richter, Cecilie, Minthon, Lennart, Brundin, Lena

“…Neuron glial 2 (NG2) cells become strongly activated in injured brain areas. The activation is characterized by increased proliferation as well as increased…”
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The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and App NL−F/NL−F mice by Nuñez-Diaz, Cristina, Andersson, Emelie, Schultz, Nina, Pocevičiūtė, Dovilė, Hansson, Oskar, Nilsson, K. Peter R., Wennström, Malin

“…Background: Amyloid beta (Aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer’s disease (AD) patients…”
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Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia by Byman, Elin, Nägga, Katarina, Gustavsson, Anna-Märta, Andersson-Assarsson, Johanna, Hansson, Oskar, Sonestedt, Emily, Wennström, Malin

“…Previous studies have shown that copy number variation (CNV) in the alpha (α)-amylase gene (AMY1A) is associated with body mass index, insulin resistance, and…”
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Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity by Gharibyan, Anna L, Islam, Tohidul, Pettersson, Nina, Golchin, Solmaz A, Lundgren, Johanna, Johansson, Gabriella, Genot, Mélany, Schultz, Nina, Wennström, Malin, Olofsson, Anders

“…Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer's disease (AD), where the ApoE4 variant…”
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Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients by Wennström, Malin, Hall, Sara, Nägga, Katarina, Londos, Elisabet, Minthon, Lennart, Hansson, Oskar

“…Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular…”
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Corticosterone-Induced Inhibition of Gliogenesis in Rat Hippocampus is Counteracted by Electroconvulsive Seizures by Wennström, Malin, Hellsten, Johan, Ekstrand, Joakim, Lindgren, Hanna, Tingström, Anders

“…Volumetric changes and glial pathology have been reported in the central nervous system (CNS) of patients with depressive disorder, an illness often associated…”
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