Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers

Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers

Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4‐dibromo‐2‐butene and tetramethyl‐1,3‐propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more tha...

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Bibliographic Details
Published in:Macromolecular bioscience Vol. 15; no. 12; pp. 1710 - 1723
Main Authors: Strassburg, Arne, Kracke, Frauke, Wenners, Julia, Jemeljanova, Anna, Kuepper, Jannis, Petersen, Hanne, Tiller, Joerg C.
Format: Journal Article
Language:English
Published: Germany Blackwell Publishing Ltd 01-12-2015
Wiley Subscription Services, Inc
Subjects:
Anti-Infective Agents - chemistry
Antiinfectives and antibacterials
antimicrobial
Bacteria
Biocides
Manganese
Membranes, Artificial
Molecular weight
non-toxic
Polybenzimidazoles
polyionenes
polyquaternium
selective
Selectivity
Staphylococcus epidermidis - growth & development
Toxicology
antimicrobial
polyionenes
selective
non-toxic
polyquaternium
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Summary:Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4‐dibromo‐2‐butene and tetramethyl‐1,3‐propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40 000 μg · mL−1. They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50/MIC is more than 20 000 for S. epidermidis. Investigations on sequentially prepared PBIs with defined molecular weight Mn and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups. Antimicrobially active and nontoxic hydrophilic polycations based on 1,4‐dibromo‐2‐butene and tetramethyl‐1,3‐propanediamine (PBI) are an alternative to toxic biocides and amphiphilic polycations. Investigations on PBIs with defined molecular weight (Mn) and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups.
Bibliography:ark:/67375/WNG-R5LLBXQ3-W
butcher shops Niemann and Vollmer
istex:A09B84C0E1ED3F1FAB922778233C45604428C005
ArticleID:MABI201500207
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201500207