Search Results - "Wenker, Ian C."

Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism by Wenker, Ian C, Kréneisz, Orsolya, Nishiyama, Akiko, Mulkey, Daniel K

“…Central chemoreception is the mechanism by which CO(2)/pH sensors regulate breathing in response to tissue pH changes. There is compelling evidence that…”
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Blood Pressure Regulation by the Rostral Ventrolateral Medulla in Conscious Rats: Effects of Hypoxia, Hypercapnia, Baroreceptor Denervation, and Anesthesia by Wenker, Ian C, Abe, Chikara, Viar, Kenneth E, Stornetta, Daniel S, Stornetta, Ruth L, Guyenet, Patrice G

“…Current understanding of the contribution of C1 neurons to blood pressure (BP) regulation derives predominantly from experiments performed in anesthetized…”
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Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death by Wenker, Ian C, Blizzard, Elizabeth A, Wagley, Pravin K, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are unknown, one…”
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Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy by Wengert, Eric R, Wenker, Ian C, Wagner, Elizabeth L, Wagley, Pravin K, Gaykema, Ronald P, Shin, Jung-Bum, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies…”
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Forebrain epileptiform activity is not required for seizure-induced apnea in a mouse model of Scn8a epilepsy by Wenker, Ian C, Boscia, Alexis R, Lewis, Christine, Tariq, Anas, Miralles, Raquel, Hanflink, Jessica C, Saraf, Priyanka, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are essentially…”
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Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe by Hawkins, Virginia E, Takakura, Ana C, Trinh, Ashley, Malheiros-Lima, Milene R, Cleary, Colin M, Wenker, Ian C, Dubreuil, Todd, Rodriguez, Elliot M, Nelson, Mark T, Moreira, Thiago S, Mulkey, Daniel K

“…Cerebral blood flow is highly sensitive to changes in CO /H where an increase in CO /H causes vasodilation and increased blood flow. Tissue CO /H also…”
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Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy by Thompson, Jeremy A., Miralles, Raquel M., Wengert, Eric R., Wagley, Pravin K., Yu, Wenxi, Wenker, Ian C., Patel, Manoj K.

“…Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder…”
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Nitric oxide activates hypoglossal motoneurons by cGMP-dependent inhibition of TASK channels and cGMP-independent activation of HCN channels by Wenker, Ian C, Benoit, Justin P, Chen, Xinnian, Liu, Hattie, Horner, Richard L, Mulkey, Daniel K

“…Nitric oxide (NO) is an important signaling molecule that regulates numerous physiological processes, including activity of respiratory motoneurons. However,…”
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Neuronal plasticity contributes to postictal death by Brodovskaya, Anastasia, Sun, Huayu, Adotevi, Nadia, Wenker, Ian C., Mitchell, Keri E., Clements, Rachel T., Kapur, Jaideep

“…Repeated generalized tonic-clonic seizures (GTCSs) are the most critical risk factor for sudden unexpected death in epilepsy (SUDEP). GTCSs can cause fatal…”
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Neurologic outcomes with cerebral oxygen monitoring in traumatic brain injury by McCarthy, Mary C., MD, Moncrief, Hugh, MD, Sands, Jean M., RN, Markert, Ronald J., PhD, Hall, Lawrence C., DO, Wenker, Ian C., BS, Anderson, Harry L., MD, Ekeh, A. Peter, MD, Walusimbi, Mbaga S., MD, Woods, Randy J., MD, Saxe, Jonathan M., MD, Tchorz, Kathryn M., MD

“…Background Optimizing cerebral oxygenation is advocated to improve outcome in head-injured patients. The purpose of this study was to compare outcomes in…”
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Opto‐ and Chemogenetic Dissection of Ictal Apnea Neural Circuitry by Wenker, Ian C., Wagley, Pravin K., Boscia, Alexis R., Lewis, Christine, Patel, Manoj K.

“…Sudden Unexpected Death in Epilepsy (SUDEP) is defined as the sudden, unexpected and unexplained death of a person with epilepsy and accounts for between 8 and…”
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Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome by Wengert, Eric R., Wagley, Pravin K., Strohm, Samantha M., Reza, Nuha, Wenker, Ian C., Gaykema, Ronald P., Christiansen, Anne, Liau, Gene, Patel, Manoj K.

“…[Display omitted] •STK-001 treatment reduces seizures in a mouse model of Dravet Syndrome.•STK-001 prolongs survival in a mouse model of Dravet…”
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A Water Nymph’s Curse and the Serotonergic Mechanism of Postictal Breathing Dysfunction by Wenker, Ian C., Patel, Manoj K.

“…Seizures Cause Prolonged Impairment of Ventilation, CO2 Chemoreception and Thermoregulation Teran FA, Sainju RK, Bravo E, Wagnon J, Kim Y, Granner A, Gehlbach…”
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Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy by Wenker, Ian C., Teran, Frida A., Wengert, Eric R., Wagley, Pravin K., Panchal, Payal S., Blizzard, Elizabeth A., Saraf, Priyanka, Wagnon, Jacy L., Goodkin, Howard P., Meisler, Miriam H., Richerson, George B., Patel, Manoj K.

“…Objective Sudden unexpected death in epilepsy (SUDEP) is an unpredictable and devastating comorbidity of epilepsy that is believed to be due to…”
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Proton detection and breathing regulation by the retrotrapezoid nucleus by Guyenet, Patrice G., Bayliss, Douglas A., Stornetta, Ruth L., Ludwig, Marie‐Gabrielle, Kumar, Natasha N., Shi, Yingtang, Burke, Peter G. R., Kanbar, Roy, Basting, Tyler M., Holloway, Benjamin B., Wenker, Ian C.

“…We discuss recent evidence which suggests that the principal central respiratory chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that…”
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Waiting to Inhale: Preventing Fatality From Seizure-Induced Apnea by Wenker, Ian C., Patel, Manoj K.

“…Diaphragmatic Pacing for the Prevention of Sudden Unexpected Death in Epilepsy Purnell BS, Braun A, Fedele D, Murugan M, Boison D. Brain Commun…”
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Somatostatin-Positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy by Wengert, Eric R, Miralles, Raquel M, Wedgwood, Kyle C A, Wagley, Pravin K, Strohm, Samantha M, Panchal, Payal S, Idrissi, Abrar Majidi, Wenker, Ian C, Thompson, Jeremy A, Gaykema, Ronald P, Patel, Manoj K

“…epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant , which encodes the voltage-gated sodium channel Na 1.6. To date, it is unclear if…”
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Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus by Guyenet, Patrice G., Bayliss, Douglas A., Stornetta, Ruth L., Kanbar, Roy, Shi, Yingtang, Holloway, Benjamin B., Souza, George M. P. R., Basting, Tyler M., Abbott, Stephen B. G., Wenker, Ian C.

“…The retrotrapezoid nucleus (RTN) regulates breathing in a CO2‐ and state‐dependent manner. RTN neurons are glutamatergic and innervate principally the…”
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Regulation of ventral surface CO2/H+‐sensitive neurons by purinergic signalling by Wenker, Ian C., Sobrinho, Cleyton R., Takakura, Ana C., Moreira, Thiago S., Mulkey, Daniel K.

“…Key points  •  The retrotrapezoid nucleus (RTN) is an important site of chemoreception, i.e. the mechanism by which the brain regulates breathing in response…”
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Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe by Sobrinho, Cleyton R., Wenker, Ian C., Poss, Erin M., Takakura, Ana C., Moreira, Thiago S., Mulkey, Daniel K.

“…Key points Several brain regions are thought to sense changes in tissue CO2/H+ to regulate breathing (i.e. central chemoreceptors) including the nucleus of the…”
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