Search Results - "Wenk, GL"

Neuropathologic changes in Alzheimer's disease by Wenk, Gary L

“…Alzheimer's disease is characterized by degenerative changes in a variety of neurotransmitter systems. These include alterations in the function of the…”
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Neuropathologic changes in Alzheimer's disease: potential targets for treatment by Wenk, Gary L

“…The cognitive symptoms of Alzheimer's disease (AD) are believed to be caused not only by the loss of neurons in the cholinergic and glutamatergic neural…”
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Microglial Activation and beta -Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice by Jantzen, Paul T, Connor, Karen E, DiCarlo, Giovanni, Wenk, Gary L, Wallace, John L, Rojiani, Amyn M, Coppola, Domenico, Morgan, Dave, Gordon, Marcia N

“…3-4-(2-Fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester (NCX-2216), a nitric oxide (NO)-releasing…”
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Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine by Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Esparza, E. E., Larkin, P. B., Fike, J. R., Wenk, G. L., Barnes, C. A.

“…Understanding how the hippocampus processes episodic memory information during neuropathological conditions is important for treatment and prevention…”
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Neuroinflammation Alters the Hippocampal Pattern of Behaviorally Induced Arc Expression by Rosi, Susanna, Ramirez-Amaya, Victor, Vazdarjanova, Almira, Worley, Paul F, Barnes, Carol A, Wenk, Gary L

“…Neuroinflammation is associated with a variety of neurological and pathological diseases, such as Alzheimer's disease (AD), and is reliably detected by the…”
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The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress by Wenk, Gary L.

“…The nucleus basalis magnocellularis (NBM) contains a population of large cholinergic (Ch) neurons that send their axons to the entire cortical mantle, the…”
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Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain by Perry, Elaine K., Lee, Mandy L.W., Martin-Ruiz, Carmen M., Court, Jennifer A., Volsen, Stephen G., Merrit, Jenny, Folly, Elizabeth, Iversen, Portia E., Bauman, Margaret L., Perry, Robert H., Wenk, Gary L.

“…OBJECTIVE: Measures of cholinergic transmitter activity were investigated in patients with autism because of reported neuropathological abnormalities in…”
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Chronic Brain Inflammation Results in Cell Loss in the Entorhinal Cortex and Impaired LTP in Perforant Path-Granule Cell Synapses by Hauss-Wegrzyniak, B., Lynch, M.A., Vraniak, P.D., Wenk, G.L.

“…Alzheimer's disease (AD) is characterized by chronic neuroinflammation, significant temporal lobe cell loss, and dementia. We investigated the influence of…”
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Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease by Hauss-Wegrzyniak, Beatrice, Dobrzanski, Pawel, Stoehr, James D, Wenk, Gary L

“…Inflammatory processes may play a critical role in the pathogenesis of the degenerative changes and cognitive impairments associated with Alzheimer's disease…”
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Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors by Barnes, C.A, Meltzer, J, Houston, F, Orr, G, McGann, K, Wenk, G.L

“…The function of the cholinergic system is known to change during normal aging and in pathological conditions such as Alzheimer’s disease. The present study was…”
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Attenuation of chronic neuroinflammation by a nitric oxide‐releasing derivative of the antioxidant ferulic acid by Wenk, Gary L., McGann‐Gramling, Kristin, Hauss‐Wegrzyniak, Beatrice, Ronchetti, Daniela, Maucci, Raffaella, Rosi, Susanna, Gasparini, Laura, Ongini, Ennio

“…Chronic neuroinflammation and oxidative stress contribute to the neurodegeneration associated with Alzheimer's disease and represent targets for therapy…”
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APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer’s disease by Mohmmad Abdul, Hafiz, Wenk, Gary L., Gramling, McGann, Hauss-Wegrzyniak, Beatrice, Butterfield, D. Allan

“…Epidemiological and biochemical studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer’s disease (AD). Mutation in the PS-1 and APP…”
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Chemokine receptor 5 antagonist d-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease by Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K., Wenk, G.L.

“…Chronic neuroinflammation plays a prominent role in the progression of Alzheimer's disease. Reactive microglia and astrocytes are observed within the…”
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Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments by Hepler, DJ, Olton, DS, Wenk, GL, Coyle, JT

“…The functional contribution of nucleus basalis magnocellularis (NBM) and the medial septal area (MSA) to memory was evaluated in two different spatial…”
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Nucleus basalis magnocellularis and medial septal area lesions differentially impair temporal memory by Meck, WH, Church, RM, Wenk, GL, Olton, DS

“…Functional dissociations between the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM) were examined using the concepts and experimental…”
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Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle by Hauss-Wegrzyniak, Beatrice, Wenk, Gary L.

“…Beta-amyloid deposition and neuroinflammation are two important features of Alzheimer's disease (AD) that may influence its progression. Chronic infusion of…”
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Regional changes in the hippocampal density of AMPA and NMDA receptors across the lifespan of the rat by Wenk, Gary L., Barnes, Carol A.

“…The current study dissected the fascia dentata (FD) and hilar region from the CA and subicular cell fields of the rat and conducted in vitro determinations of…”
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The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition by WILLARD, L. B, HAUSS-WEGRZYNIAK, B, DANYSZ, W, WENK, G. L

“…The proinflammagen lipopolysaccharide (LPS) was infused chronically (37 days) into the basal forebrain of rats. The current study determined whether the…”
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Cognitive enhancers: potential strategies and experimental results by Wenk, G L, Olton, D S

“…1. Cognitive impairments follow natural processes such as aging, diseases, exposure to neurotoxins, and traumatic injury. In all of these instances, the brain…”
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Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats by Hauss-Wegrzyniak, Beatrice, Vannucchi, Maria G., Wenk, Gary L.

“…We investigated the ultrastructural, immunohistochemical, biochemical and behavioral effects of chronic neuroinflammation in young rats produced by injection…”
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