Search Results - "Wenk, G.L."

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory by Lana, D., Di Russo, J., Mello, T., Wenk, G.L., Giovannini, M.G.

“…•mTOR/p70S6K activation in area CA3 are involved in long term memory formation.•Rapamycin inhibited mTOR/p70S6K activation at 4h and impaired long term memory…”
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Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation by Marchalant, Y, Rosi, S, Wenk, G.L

“…Abstract Cannabinoid receptors (CBr) stimulation induces numerous central and peripheral effects. A growing interest in the beneficial properties of…”
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Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism by Hopp, S.C, D’Angelo, H.M, Royer, S.E, Kaercher, R.M, Adzovic, L, Wenk, G.L

“…Highlights • Ryanodine receptor expression is negatively correlated with memory in aged rats. • Antagonism of ryanodine receptors improves spatial memory…”
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129. Blockade of L-type voltage dependent calcium channels or ryanodine receptors during chronic neuroinflammation improves spatial memory and reduces expression of inflammatory markers by Hopp, S.C, Royer, S.E, D’Angelo, H.M, Kaercher, R.M, Adzovic, L, Crockett, A.M, Wenk, G.L

“…Chronic neuroinflammation is a key component of Alzheimer’s disease and other neurodegenerative processes. Prolonged neuroinflammation produces elevation of…”
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Chronic Brain Inflammation Results in Cell Loss in the Entorhinal Cortex and Impaired LTP in Perforant Path-Granule Cell Synapses by Hauss-Wegrzyniak, B., Lynch, M.A., Vraniak, P.D., Wenk, G.L.

“…Alzheimer's disease (AD) is characterized by chronic neuroinflammation, significant temporal lobe cell loss, and dementia. We investigated the influence of…”
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Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat by Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C. A., Wenk, G.L.

“…Neuroinflammation is reliably associated with the pathogenesis of a number of neurodegenerative diseases, and can be detected by the presence of activated…”
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Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain by Marchalant, Y, Brothers, H M, Wenk, G L

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New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment by Marchalant, Y, Brothers, H M, Wenk, G L

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Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors by Barnes, C.A, Meltzer, J, Houston, F, Orr, G, McGann, K, Wenk, G.L

“…The function of the cholinergic system is known to change during normal aging and in pathological conditions such as Alzheimer’s disease. The present study was…”
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Chemokine receptor 5 antagonist d-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease by Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K., Wenk, G.L.

“…Chronic neuroinflammation plays a prominent role in the progression of Alzheimer's disease. Reactive microglia and astrocytes are observed within the…”
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The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition by WILLARD, L. B, HAUSS-WEGRZYNIAK, B, DANYSZ, W, WENK, G. L

“…The proinflammagen lipopolysaccharide (LPS) was infused chronically (37 days) into the basal forebrain of rats. The current study determined whether the…”
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The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease by Wenk, G.L, McGann, K, Hauss-Wegrzyniak, B, Rosi, S

“…Inflammation and reduced forebrain norepinephrine are features of Alzheimer's disease that may interact to contribute to the degeneration of specific neural…”
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Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats by Willard, B, Hauss-Wegrzyniak, B, Wenk, G.L

“…Inflammatory processes may play a critical role in the degeneration of basal forebrain cholinergic cells that underlies some of the cognitive impairments…”
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S12 PRECLINICAL BASIS FOR MEMANTINE EFFICACY IN ALZHEIMER??S DISEASE by Danysz, W., Wenk, G.L., Banerjee, P., Parsons, C.G.

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The presence of the app swe mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation by Wenk, G.L, McGann-Gramling, K, Hauss-Wegrzyniak, B

“…Neuroinflammation, and elevated levels of inflammatory proteins, such as tumor necrosis factor-α, and the deposition of β-amyloid may interact to contribute to…”
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The presence of the APPSWE mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation by WENK, G. L, MCGANN-GRAMLING, K, HAUSS-WEGRZYNIAK, B

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Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors by Woodruff-Pak, D.S, Vogel, R.W, Wenk, G.L

“…Patch-clamp recordings of single ion channel activity demonstrated that donepezil, but not galantamine, could be blocked by the nicotinic cholinergic…”
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Neurobiological Consequences of Long-Term Estrogen Therapy by Marriott, L. K., Wenk, G. L.

“…Postmenopausal women demonstrate an increased incidence of Alzheimer's disease (AD). Epidemiological evidence suggests that estrogen replacement therapy (ERT)…”
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The effect of a novel NO-NSAID on chronic neuroinflammation by Baker, L.M., Hauss-Wegrzyniak, B., Wenk, G.L.

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Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance by Wrenn, C.C, Marriott, L.K, Kinney, J.W, Holmes, A, Wenk, G.L, Crawley, J.N

“…Galanin-overexpressing transgenic mice (GAL-tg) generated on a dopamine β-hydroxylase promoter were previously shown to express high levels of galanin mRNA in…”
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