Search Results - "Wenk, G. L."

Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine by Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Esparza, E. E., Larkin, P. B., Fike, J. R., Wenk, G. L., Barnes, C. A.

“…Understanding how the hippocampus processes episodic memory information during neuropathological conditions is important for treatment and prevention…”
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Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat by Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C. A., Wenk, G.L.

“…Neuroinflammation is reliably associated with the pathogenesis of a number of neurodegenerative diseases, and can be detected by the presence of activated…”
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Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism by Hopp, S.C, D’Angelo, H.M, Royer, S.E, Kaercher, R.M, Adzovic, L, Wenk, G.L

“…Highlights • Ryanodine receptor expression is negatively correlated with memory in aged rats. • Antagonism of ryanodine receptors improves spatial memory…”
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Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation by Marchalant, Y, Rosi, S, Wenk, G.L

“…Abstract Cannabinoid receptors (CBr) stimulation induces numerous central and peripheral effects. A growing interest in the beneficial properties of…”
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Chronic Brain Inflammation Results in Cell Loss in the Entorhinal Cortex and Impaired LTP in Perforant Path-Granule Cell Synapses by Hauss-Wegrzyniak, B., Lynch, M.A., Vraniak, P.D., Wenk, G.L.

“…Alzheimer's disease (AD) is characterized by chronic neuroinflammation, significant temporal lobe cell loss, and dementia. We investigated the influence of…”
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Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors by Barnes, C.A, Meltzer, J, Houston, F, Orr, G, McGann, K, Wenk, G.L

“…The function of the cholinergic system is known to change during normal aging and in pathological conditions such as Alzheimer’s disease. The present study was…”
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Chemokine receptor 5 antagonist d-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease by Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K., Wenk, G.L.

“…Chronic neuroinflammation plays a prominent role in the progression of Alzheimer's disease. Reactive microglia and astrocytes are observed within the…”
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The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition by WILLARD, L. B, HAUSS-WEGRZYNIAK, B, DANYSZ, W, WENK, G. L

“…The proinflammagen lipopolysaccharide (LPS) was infused chronically (37 days) into the basal forebrain of rats. The current study determined whether the…”
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The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress by Wenk, Gary L.

“…The nucleus basalis magnocellularis (NBM) contains a population of large cholinergic (Ch) neurons that send their axons to the entire cortical mantle, the…”
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Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain by Perry, Elaine K., Lee, Mandy L.W., Martin-Ruiz, Carmen M., Court, Jennifer A., Volsen, Stephen G., Merrit, Jenny, Folly, Elizabeth, Iversen, Portia E., Bauman, Margaret L., Perry, Robert H., Wenk, Gary L.

“…OBJECTIVE: Measures of cholinergic transmitter activity were investigated in patients with autism because of reported neuropathological abnormalities in…”
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The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease by Wenk, G.L, McGann, K, Hauss-Wegrzyniak, B, Rosi, S

“…Inflammation and reduced forebrain norepinephrine are features of Alzheimer's disease that may interact to contribute to the degeneration of specific neural…”
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Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats by Willard, B, Hauss-Wegrzyniak, B, Wenk, G.L

“…Inflammatory processes may play a critical role in the degeneration of basal forebrain cholinergic cells that underlies some of the cognitive impairments…”
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Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease by Hauss-Wegrzyniak, Beatrice, Dobrzanski, Pawel, Stoehr, James D, Wenk, Gary L

“…Inflammatory processes may play a critical role in the pathogenesis of the degenerative changes and cognitive impairments associated with Alzheimer's disease…”
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Brain Infusion of Lipopolysaccharide Increases Uterine Growth as a Function of Estrogen Replacement Regimen: Suppression of Uterine Estrogen Receptor-α by Constant, But Not Pulsed, Estrogen Replacement by Marriott, L. K, McGann-Gramling, K. R, Hauss-Wegrzyniak, B, Sheldahl, L. C, Shapiro, R. A, Dorsa, D. M, Wenk, G. L

“…The effects of estrogen therapy can differ depending on the regimen of estrogen administration. In addition, estrogen can modulate the effects of stressors. To…”
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Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats by Hauss-Wegrzyniak, Beatrice, Vannucchi, Maria G., Wenk, Gary L.

“…We investigated the ultrastructural, immunohistochemical, biochemical and behavioral effects of chronic neuroinflammation in young rats produced by injection…”
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LPS-induced neuroinflammatory effects do not recover with time by Hauss-Wegrzyniak, Beatrice, Vraniak, Peter D, Wenk, Gary L

“…Inflammatory processes develop in the vicinity of the neuro-pathological hallmarks associated with Alzheimerʼs disease (AD) and may play a role in the…”
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Long-Term Estrogen Therapy Worsens the Behavioral and Neuropathological Consequences of Chronic Brain Inflammation by Marriott, L. K, Hauss-Wegrzyniak, B, Benton, R. S, Vraniak, P. D, Wenk, G. L

“…Alzheimer's disease (AD) is accompanied by chronic neuroinflammation and occurs with greater incidence in postmenopausal women. The increased incidence may be…”
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Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors by Woodruff-Pak, D.S, Vogel, R.W, Wenk, G.L

“…Patch-clamp recordings of single ion channel activity demonstrated that donepezil, but not galantamine, could be blocked by the nicotinic cholinergic…”
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Neuropathologic changes in Alzheimer's disease: potential targets for treatment by Wenk, Gary L

“…The cognitive symptoms of Alzheimer's disease (AD) are believed to be caused not only by the loss of neurons in the cholinergic and glutamatergic neural…”
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Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory by Lana, D., Di Russo, J., Mello, T., Wenk, G.L., Giovannini, M.G.

“…•mTOR/p70S6K activation in area CA3 are involved in long term memory formation.•Rapamycin inhibited mTOR/p70S6K activation at 4h and impaired long term memory…”
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