Search Results - "Weng, Chunhua"

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity by Shen, Xiujin, Wang, Haibing, Weng, Chunhua, Jiang, Hong, Chen, Jianghua

“…Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently…”
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Translating evidence into practice: eligibility criteria fail to eliminate clinically significant differences between real-world and study populations by Averitt, Amelia J., Weng, Chunhua, Ryan, Patrick, Perotte, Adler

“…Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may…”
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Defining and measuring completeness of electronic health records for secondary use by Weiskopf, Nicole G., Hripcsak, George, Swaminathan, Sushmita, Weng, Chunhua

“…[Display omitted] •The completeness of EHR data is dependent upon the definition of completeness being used.•We present four definitions of EHR completeness:…”
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Evaluating large language models on medical evidence summarization by Tang, Liyan, Sun, Zhaoyi, Idnay, Betina, Nestor, Jordan G., Soroush, Ali, Elias, Pierre A., Xu, Ziyang, Ding, Ying, Durrett, Greg, Rousseau, Justin F., Weng, Chunhua, Peng, Yifan

“…Recent advances in large language models (LLMs) have demonstrated remarkable successes in zero- and few-shot performance on various downstream tasks, paving…”
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Doc2Hpo: a web application for efficient and accurate HPO concept curation by Liu, Cong, Peres Kury, Fabricio Sampaio, Li, Ziran, Ta, Casey, Wang, Kai, Weng, Chunhua

“…We present Doc2Hpo, an interactive web application that enables interactive and efficient phenotype concept curation from clinical text with automated concept…”
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Deep Phenotyping on Electronic Health Records Facilitates Genetic Diagnosis by Clinical Exomes by Son, Jung Hoon, Xie, Gangcai, Yuan, Chi, Ena, Lyudmila, Li, Ziran, Goldstein, Andrew, Huang, Lulin, Wang, Liwei, Shen, Feichen, Liu, Hongfang, Mehl, Karla, Groopman, Emily E., Marasa, Maddalena, Kiryluk, Krzysztof, Gharavi, Ali G., Chung, Wendy K., Hripcsak, George, Friedman, Carol, Weng, Chunhua, Wang, Kai

“…Integration of detailed phenotype information with genetic data is well established to facilitate accurate diagnosis of hereditary disorders. As a rich source…”
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A comparative study of pre-trained language models for named entity recognition in clinical trial eligibility criteria from multiple corpora by Li, Jianfu, Wei, Qiang, Ghiasvand, Omid, Chen, Miao, Lobanov, Victor, Weng, Chunhua, Xu, Hua

“…Abstract Background Clinical trial protocols are the foundation for advancing medical sciences, however, the extraction of accurate and meaningful information…”
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Guideline concordant care for prevention of acute chemotherapy-induced nausea and vomiting in children, adolescents, and young adults by Beauchemin, Melissa, Sung, Lillian, Hershman, Dawn L., Weng, Chunhua, Dupuis, L. Lee, Schnall, Rebecca

“…Purpose Prescribing guideline-recommended anti-emetics is an effective strategy to prevent CINV. However, the rate of guideline-concordant care is not…”
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Genome-wide polygenic score to predict chronic kidney disease across ancestries by Khan, Atlas, Turchin, Michael C., Patki, Amit, Srinivasasainagendra, Vinodh, Shang, Ning, Nadukuru, Rajiv, Jones, Alana C., Malolepsza, Edyta, Dikilitas, Ozan, Kullo, Iftikhar J., Schaid, Daniel J., Karlson, Elizabeth, Ge, Tian, Meigs, James B., Smoller, Jordan W., Lange, Christoph, Crosslin, David R., Jarvik, Gail P., Bhatraju, Pavan K., Hellwege, Jacklyn N., Chandler, Paulette, Torvik, Laura Rasmussen, Fedotov, Alex, Liu, Cong, Kachulis, Christopher, Lennon, Niall, Abul-Husn, Noura S., Cho, Judy H., Ionita-Laza, Iuliana, Gharavi, Ali G., Chung, Wendy K., Hripcsak, George, Weng, Chunhua, Nadkarni, Girish, Irvin, Marguerite R., Tiwari, Hemant K., Kenny, Eimear E., Limdi, Nita A., Kiryluk, Krzysztof

“…Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and…”
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Polygenic risk alters the penetrance of monogenic kidney disease by Khan, Atlas, Shang, Ning, Nestor, Jordan G., Weng, Chunhua, Hripcsak, George, Harris, Peter C., Gharavi, Ali G., Kiryluk, Krzysztof

“…Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and environmental risks. Autosomal dominant polycystic kidney disease…”
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Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus by Zhu, Huanhuan, Bai, Mengqiu, Xie, Xishao, Wang, Junni, Weng, Chunhua, Dai, Huifen, Chen, Jianghua, Han, Fei, Lin, Weiqiang

“…Background: Metabolomics is useful in elucidating the progression of diabetes; however, the follow-up changes in metabolomics among health, diabetes mellitus,…”
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Rapid exome sequencing in PICU patients with new-onset metabolic or neurological disorders by Carey, Abigail S., Schacht, John P., Umandap, Christine, Fasel, David, Weng, Chunhua, Cappell, Joshua, Chung, Wendy K., Kernie, Steven G.

“…Background Genomic assessment previously took months to result and was unable to impact clinical care in the pediatric intensive care unit (PICU). The advent…”
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The Burden of Candidate Pathogenic Variants for Kidney and Genitourinary Disorders Emerging From Exome Sequencing by Rasouly, Hila Milo, Groopman, Emily E, Heyman-Kantor, Reuben, Fasel, David A, Mitrotti, Adele, Westland, Rik, Bier, Louise, Weng, Chunhua, Ren, Zhong, Copeland, Brett, Krithivasan, Priya, Chung, Wendy K, Sanna-Cherchi, Simone, Goldstein, David B, Gharavi, Ali G

“…Exome sequencing is increasingly being used for clinical diagnostics, with an impetus to expand reporting of incidental findings across a wide range of…”
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Valx: A System for Extracting and Structuring Numeric Lab Test Comparison Statements from Text by Hao, Tianyong, Liu, Hongfang, Weng, Chunhua

“…To develop an automated method for extracting and structuring numeric lab test comparison statements from text and evaluate the method using clinical trial…”
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The Mitochondria-Targeted Metabolic Tubular Injury in Diabetic Kidney Disease by Jiang, Hong, Shao, Xue, Jia, Sha, Qu, Lihui, Weng, Chunhua, Shen, Xiujin, Wang, Yucheng, Huang, Hongfeng, Wang, Yingying, Wang, Cuili, Feng, Shi, Wang, Meizhen, Feng, Huajun, Geekiyanage, Sudarshanee, Davidson, Alan James, Chen, Jianghua

“…Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD) worldwide, and the importance of tubular injury has been highlighted in…”
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A deep database of medical abbreviations and acronyms for natural language processing by Grossman Liu, Lisa, Grossman, Raymond H., Mitchell, Elliot G., Weng, Chunhua, Natarajan, Karthik, Hripcsak, George, Vawdrey, David K.

“…The recognition, disambiguation, and expansion of medical abbreviations and acronyms is of upmost importance to prevent medically-dangerous misinterpretation…”
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Performance of Retrieval-Augmented Large Language Models to Recommend Head and Neck Cancer Clinical Trials by Hung, Tony K W, Kuperman, Gilad J, Sherman, Eric J, Ho, Alan L, Weng, Chunhua, Pfister, David G, Mao, Jun J

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Towards clinical data-driven eligibility criteria optimization for interventional COVID-19 clinical trials by Kim, Jae Hyun, Ta, Casey N, Liu, Cong, Sung, Cynthia, Butler, Alex M, Stewart, Latoya A, Ena, Lyudmila, Rogers, James R, Lee, Junghwan, Ostropolets, Anna, Ryan, Patrick B, Liu, Hao, Lee, Shing M, Elkind, Mitchell S V, Weng, Chunhua

“…This research aims to evaluate the impact of eligibility criteria on recruitment and observable clinical outcomes of COVID-19 clinical trials using electronic…”
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Formal representation of eligibility criteria: A literature review by Weng, Chunhua, Tu, Samson W., Sim, Ida, Richesson, Rachel

“…Standards-based, computable knowledge representations for eligibility criteria are increasingly needed to provide computer-based decision support for automated…”
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Natural language processing (NLP) tools in extracting biomedical concepts from research articles: a case study on autism spectrum disorder by Peng, Jacqueline, Zhao, Mengge, Havrilla, James, Liu, Cong, Weng, Chunhua, Guthrie, Whitney, Schultz, Robert, Wang, Kai, Zhou, Yunyun

“…Natural language processing (NLP) tools can facilitate the extraction of biomedical concepts from unstructured free texts, such as research articles or…”
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