Search Results - "Wendt, Michael K."

Phosphoproteins in extracellular vesicles as candidate markers for breast cancer by Chen, I-Hsuan, Xue, Liang, Hsu, Chuan-Chih, Paez, Juan Sebastian Paez, Pan, Li, Andaluz, Hillary, Wendt, Michael K., Iliuk, Anton B., Zhu, Jian-Kang, Tao, W. Andy

“…The state of protein phosphorylation can be a key determinant of cellular physiology such as early-stage cancer, but the development of phosphoproteins in…”
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Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer by Shinde, Aparna, Wilmanski, Tomasz, Chen, Hao, Teegarden, Dorothy, Wendt, Michael K

“…Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic…”
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Autocrine Fibronectin Inhibits Breast Cancer Metastasis by Shinde, Aparna, Libring, Sarah, Alpsoy, Aktan, Abdullah, Ammara, Schaber, James A, Solorio, Luis, Wendt, Michael K

“…Both epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are linked to metastasis via their ability to increase invasiveness…”
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Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells by Cai, Bo, Kim, Dongwook, Akhand, Saeed, Sun, Yixing, Cassell, Robert J, Alpsoy, Aktan, Dykhuizen, Emily C, Van Rijn, Richard M, Wendt, Michael K, Krusemark, Casey J

“…We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach…”
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The paradoxical functions of EGFR during breast cancer progression by Ali, Remah, Wendt, Michael K

“…The epidermal growth factor receptor (EGFR) is one of the most well-studied signaling pathways in cancer progression. As a result, numerous therapeutics…”
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SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer by Chen, Hao, Libring, Sarah, Ruddraraju, Kasi Viswanatharaju, Miao, Jinmin, Solorio, Luis, Zhang, Zhong-Yin, Wendt, Michael K.

“…Metastatic breast cancer (MBC) is an extremely recalcitrant disease capable of bypassing current targeted therapies via engagement of several growth promoting…”
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Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer by Wendt, Michael K, Taylor, Molly A, Schiemann, Barbara J, Schiemann, William P

“…Reduced epithelial cadherin (E-cad) is a hallmark of invasive carcinomas that have acquired epithelial-mesenchymal transition (EMT) phenotypes. Here we show…”
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Epithelial to Mesenchymal Transition Promotes Breast Cancer Progression via a Fibronectin-dependent STAT3 Signaling Pathway by Balanis, Nikolas, Wendt, Michael K., Schiemann, Barbara J., Wang, Zhenghe, Schiemann, William P., Carlin, Cathleen R.

“…We previously established that overexpression of the EGF receptor (EGFR) is sufficient to induce tumor formation by otherwise nontransformed mammary epithelial…”
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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression by Coleman, Michael F, Cotul, Eylem Kulkoyluoglu, Pfeil, Alexander J, Devericks, Emily N, Safdar, Muhammad H, Monteiro, Marvis, Chen, Hao, Ho, Alyssa N, Attaar, Numair, Malian, Hannah M, Kiesel, Violet A, Ramos, Alexis, Smith, Matthew, Panchal, Heena, Mailloux, Adam, Teegarden, Dorothy, Hursting, Stephen D, Wendt, Michael K

“…Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and…”
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The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial-mesenchymal phenotype by Herndon, Mary E, Ayers, Mitchell, Gibson-Corley, Katherine, Wendt, Michael K, Wallrath, Lori L, Henry, Michael D, Stipp, Christopher S

“…Epithelial-mesenchymal transitions (EMTs) are thought to promote metastasis via downregulation of E-cadherin and upregulation of mesenchymal markers such as…”
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Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases by Uzunalli, Gozde, Dieterly, Alexandra M., Kemet, Chinyere M., Weng, Hsin-Yi, Soepriatna, Arvin H., Goergen, Craig J., Shinde, Aparna B., Wendt, Michael K., Lyle, L. Tiffany

“…Invasion of the brain by non-small cell lung cancer (NSCLC) results in a shift of the blood-brain barrier (BBB) to the insufficiently characterized blood-tumor…”
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Pyruvate carboxylase and cancer progression by Kiesel, Violet A, Sheeley, Madeline P, Coleman, Michael F, Cotul, Eylem Kulkoyluoglu, Donkin, Shawn S, Hursting, Stephen D, Wendt, Michael K, Teegarden, Dorothy

“…Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the…”
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Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library by Kim, Dongwook, Sun, Yixing, Xie, Dan, Denton, Kyle E, Chen, Hao, Lin, Hang, Wendt, Michael K, Post, Carol Beth, Krusemark, Casey J

“…As aberrant activity of protein kinases is observed in many disease states, these enzymes are common targets for therapeutics and detection of activity levels…”
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Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1 by Krabill, Aaron D, Chen, Hao, Hussain, Sajjad, Hewitt, Chad S, Imhoff, Ryan D, Muli, Christine S, Das, Chittaranjan, Galardy, Paul J, Wendt, Michael K, Flaherty, Daniel P

“…The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of…”
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Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease by Zimmerman, Noah P., Vongsa, Rebecca A., Wendt, Michael K., Dwinell, Michael B.

“…Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and…”
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Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells by Kiesel, Violet A, Sheeley, Madeline P, Hicks, Emily M, Andolino, Chaylen, Donkin, Shawn S, Wendt, Michael K, Hursting, Stephen D, Teegarden, Dorothy

“…Regions of hypoxia are common in solid tumors and drive changes in gene expression that increase risk of cancer metastasis. Tumor cells must respond to the…”
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Deptor Enhances Triple-Negative Breast Cancer Metastasis and Chemoresistance through Coupling to Survivin Expression by Parvani, Jenny G, Davuluri, Gangarao, Wendt, Michael K, Espinosa, Christine, Tian, Maozhen, Danielpour, David, Sossey-Alaoui, Khalid, Schiemann, William P

“…Abstract Transforming growth factor–β (TGF-β) functions to suppress tumorigenesis in normal mammary tissues and early-stage breast cancers and, paradoxically,…”
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The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6 by Wendt, Michael K, Williams, Whitney K, Pascuzzi, Pete E, Balanis, Nikolas G, Schiemann, Barbara J, Carlin, Cathleen R, Schiemann, William P

“…Abstract Numerous studies by our lab and others demonstrate that epidermal growth factor receptor (EGFR) plays critical roles in primary breast cancer (BC)…”
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Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancer by Shinde, Aparna, Kulkoyluoglu Cotul, Eylem, Chen, Hao, Smith, Andrew, Libring, Sarah, Solorio, Luis, Wendt, Michael K.

“…Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2 + subtype of breast cancer. Using an isogeneic progression…”
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Fibroblast growth receptor 1 is regulated by G-quadruplex in metastatic breast cancer by Lin, Hang, Hassan Safdar, Muhammad, Washburn, Sarah, S. Akhand, Saeed, Dickerhoff, Jonathan, Ayers, Mitchell, Monteiro, Marvis, Solorio, Luis, Yang, Danzhou, Wendt, Michael K.

“…Limiting cellular plasticity is of key importance for the therapeutic targeting of metastatic breast cancer (MBC). Fibroblast growth receptor (FGFR) is a…”
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