Search Results - "Wendt, Karen L."

Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens by Lee, Jin Woo, Collins, Jennifer E., Hulverson, Matthew A., Aguila, Laarni Kendra T., Kim, Caroline M., Wendt, Karen L., Chakrabarti, Debopam, Ojo, Kayode K., Wood, Gwendolyn E., Van Voorhis, Wesley C., Cichewicz, Robert H.

“…Xanthoquinodins make up a distinctive class of xanthone-anthraquinone heterodimers reported as secondary metabolites from several fungal species. Through a…”
Get full text

Identification of natural product modulators of Merkel cell carcinoma cell growth and survival by Smith, Emily A., Hill, Natasha T., Gelb, Tara, Garman, Khalid A., Goncharova, Ekaterina I., Bokesch, Heidi R., Kim, Chang-Kwon, Wendt, Karen L., Cichewicz, Robert H., Gustafson, Kirk R., Brownell, Isaac, Henrich, Curtis J.

“…Merkel cell carcinoma (MCC) is a rare, but aggressive skin cancer the incidence of which has increased significantly in recent years. The majority of MCCs have…”
Get full text

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea by Kim, Chang-Kwon, Krumpe, Lauren R. H., Smith, Emily, Henrich, Curtis J., Brownell, Isaac, Wendt, Karen L., Cichewicz, Robert H., O’Keefe, Barry R., Gustafson, Kirk R.

“…A new 11 amino acid linear peptide named roseabol A (1) and the known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the…”
Get full text

Identification of fungal natural products with potent inhibition in Toxoplasma gondii by Jiang, Tiantian, Godinez-Macias, Karla P, Collins, Jennifer E, Lee, Jin Woo, Wendt, Karen L, Carolino, Krypton, Chakrabarti, Debopam, Cichewicz, Robert H, Winzeler, Elizabeth A

“…In an effort to identify novel compounds with potent inhibition against a phenotypic screen was performed utilizing a library of 683 pure compounds derived…”
Get full text

Identification of Fungus-Derived Natural Products as New Antigiardial Scaffolds by Hulverson, Matthew A, Michaels, Samantha A, Lee, Jin Woo, Wendt, Karen L, Tran, Linh T, Choi, Ryan, Van Voorhis, Wesley C, Cichewicz, Robert H, Ojo, Kayode K

“…There is an unmet need for effective therapies for treating diseases associated with the intestinal parasite Giardia lamblia. In this study, a library of…”
Get full text

Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies by Anderson, Victoria M, Wendt, Karen L, Najar, Fares Z, McCall, Laura-Isobel, Cichewicz, Robert H

“…The success of natural product-based drug discovery is predicated on having chemical collections that offer broad coverage of metabolite diversity. We propose…”
Get full text

Correction for Anderson et al., "Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies" by Anderson, Victoria M, Wendt, Karen L, Najar, Fares Z, McCall, Laura-Isobel, Cichewicz, Robert H

Get full text

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents against Trypanosoma cruzi by Bernatchez, Jean A, Kil, Yun-Seo, Barbosa da Silva, Elany, Thomas, Diane, McCall, Laura-Isobel, Wendt, Karen L, Souza, Julia M, Ackermann, Jasmin, McKerrow, James H, Cichewicz, Robert H, Siqueira-Neto, Jair L

“…Safe and effective treatments for Chagas disease, a potentially fatal parasitic infection associated with cardiac and gastrointestinal pathology and caused by…”
Get full text

Resolving a Natural Product Cold Case: Elucidation of Fusapyrone Structure and Absolute Configuration and Demonstration of Their Fungal Biofilm Disrupting Properties by Kil, Yun-Seo, You, Jianlan, Wendt, Karen L., King, Jarrod B., Cichewicz, Robert H.

“…Fusapyrones are fungal metabolites, which have been reported to have broad-spectrum antibacterial and antifungal properties. Despite the first members of this…”
Get full text

Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics by Lee, Jin Woo, Collins, Jennifer E, Wendt, Karen L, Chakrabarti, Debopam, Cichewicz, Robert H

“…Malaria remains a worldwide threat, afflicting over 200 million people each year. The emergence of drug resistance against existing therapeutics threatens to…”
Get full text

Genomic and metabolomic diversity within a familial population of Aspergillus flavus by Moore, Geromy G, Mack, Brian M, Wendt, Karen L, Castano-Duque, Lina, Anderson, Victoria M, Cichewicz, Robert H

“…Aspergillus flavus is an agriculturally significant micro-fungus having potential to contaminate food and feed crops with toxic secondary metabolites such as…”
Get full text

Iron(III) Binding Properties of PF1140, a Fungal N‑Hydroxypyridone, and Activity against Mycoplasma genitalium by Peramuna, Thilini, Kim, Caroline M., Aguila, Laarni Kendra T., Wendt, Karen L., Wood, Gwendolyn E., Cichewicz, Robert H.

“…Mycoplasma genitalium is a sexually transmitted bacterium associated with urogenital disease syndromes in the US and worldwide. The global rise in drug…”
Get full text

Persephacin Is a Broad-Spectrum Antifungal Aureobasidin Metabolite That Overcomes Intrinsic Resistance in Aspergillus fumigatus by Du, Lin, Haldar, Saikat, King, Jarrod B., Mattes, Allison O., Srivastava, Shikha, Wendt, Karen L., You, Jianlan, Cunningham, Chad, Cichewicz, Robert H.

“…Fungi pose a persistent threat to humankind with worrying indications that emerging and re-emerging pathogens (e.g., Candida auris, Coccidioides spp.,…”
Get full text

The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium by Wood, Gwendolyn E, Lee, Jin Woo, Peramuna, Thilini, Wendt, Karen L, Kim, Caroline M, Aguila, Laarni Kendra T, Calderon, Claire L, Cichewicz, Robert H

“…Antimicrobial resistance is extremely common in , a frequent cause of urethritis in men and cervicitis, vaginitis, and pelvic inflammatory disease in women…”
Get more information

Inhibitor of Chromosome Segregation in Pseudomonas aeruginosa from Fungal Extracts by Zhao, Hang, Peramuna, Thilini, Ajmal, Sidra, Wendt, Karen L., Petrushenko, Zoya M., Premachandra, Kaushika, Cichewicz, Robert H., Rybenkov, Valentin V.

“…Chromosome segregation is an essential cellular process that has the potential to yield numerous targets for drug development. This pathway is presently…”
Get full text

Chemoreactive 2,5-Diketopiperazines from a Penicillium sp., Structure Revision of Reported Analogues and Proposed Facile Transformation Pathways by Khong, Quan T., Smith, Emily A., Wendt, Karen L., Dalilian, Masoumeh, Goncharova, Ekaterina I., Brownell, Isaac, Cichewicz, Robert H., Henrich, Curtis J., Beutler, John A., O’Keefe, Barry R., Du, Lin

“…Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer. Two new prenylated indole 2,5-diketopiperazine alkaloids, brevianamides E1 (1) and E2…”
Get full text

Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum by Senadeera, Sarath P. D., Wang, Dongdong, Kim, Chang-Kwon, Smith, Emily A., Durrant, David E., Alexander, Patrick A., Wendt, Karen L., Stephen, Andrew G., Morrison, Deborah K., Cichewicz, Robert H., Henrich, Curtis J., Beutler, John A.

“…Seven new peptaibols named tolypocladamides A–G have been isolated from an extract of the fungus Tolypocladium inflatum, which inhibits the interaction between…”
Get full text

Assessing Microbial Metabolic and Biological Diversity to Inform Natural Product Library Assembly by Anderson, Victoria M, Wendt, Karen L, Caughron, James B, Matlock, Hagan P, Rangu, Nitin, Najar, Fares Z, Miller, Andrew N, Luttenton, Mark R, Cichewicz, Robert H

“…The pressing need for novel chemical matter to support bioactive compound discovery has led natural product researchers to explore a wide range of source…”
Get full text

Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods by Tran, Trong D., Wilson, Brice A.P., Henrich, Curtis J., Wendt, Karen L., King, Jarrod, Cichewicz, Robert H., Stchigel, Alberto M., Miller, Andrew N., O'Keefe, Barry R., Gustafson, Kirk R.

“…Following the discovery of a new class of compounds that inhibit the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) protease in a prior…”
Get full text

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities by Tran, Trong D, Wilson, Brice A. P, Henrich, Curtis J, Staudt, Louis M, Krumpe, Lauren R. H, Smith, Emily A, King, Jarrod, Wendt, Karen L, Stchigel, Alberto M, Miller, Andrew N, Cichewicz, Robert H, O’Keefe, Barry R, Gustafson, Kirk R

“…Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1–6, together with five known…”
Get full text