In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications

Thiolated o‐quinone‐capped electrocatalysts modeled on the naturally occurring o‐quinone cofactor pyrroloquinoline quinone (PQQ) were designed and synthesized for the development of biosensor devices. The o‐quinone‐capped electrocatalysts self assembled on gold electrodes through a thiolated phenyle...

Full description

Saved in:

Bibliographic Details
Published in:	Electroanalysis (New York, N.Y.) Vol. 23; no. 10; pp. 2275 - 2279
Main Authors:	Wendland, Tom R., Muntean, Brian S., Kaur, Jaskiran, Mukherjee, Jhindan, Chen, Jie, Tan, Xinxuan, Attygalle, Dinesh, Collins, Robert W., Kirchhoff , Jon R., Tillekeratne , L. M. Viranga
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-10-2011 WILEY‐VCH Verlag
Subjects:	Amperometric biosensors Capping Electrical measurements Electrocatalysts Electrodes Nucleophiles Quinones Self assembly Thiols
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Thiolated o‐quinone‐capped electrocatalysts modeled on the naturally occurring o‐quinone cofactor pyrroloquinoline quinone (PQQ) were designed and synthesized for the development of biosensor devices. The o‐quinone‐capped electrocatalysts self assembled on gold electrodes through a thiolated phenyleneethynylene linkage to form a monolayer less than 2 nm in thickness. Cyclic voltammetric measurements demonstrated reversible electrochemical properties between the quinone and hydroquinone forms of the head group. In an amperometric sensing mode, the modified electrodes reproducibly detected ethanethiol at micromolar levels demonstrating their robust electrocatalytic activity toward thiols. Their redox cycling and electrocatalytic properties show promise for detection of biologically important thiols and other nucleophiles.
Bibliography:	istex:EF96A239A65155E962B0B88E74595C6EAE6C57CF ark:/67375/WNG-D8VHTZ5J-Q ArticleID:ELAN201100276 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1040-0397 1521-4109
DOI:	10.1002/elan.201100276