Search Results - "Wen, Zhining"

Advancing Adverse Drug Reaction Prediction with Deep Chemical Language Model for Drug Safety Evaluation by Lin, Jinzhu, He, Yujie, Ru, Chengxiang, Long, Wulin, Li, Menglong, Wen, Zhining

“…The accurate prediction of adverse drug reactions (ADRs) is essential for comprehensive drug safety evaluation. Pre-trained deep chemical language models have…”
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Unraveling Structural Alerts in Marketed Drugs for Improving Adverse Outcome Pathway Framework of Drug-Induced QT Prolongation by Long, Wulin, Li, Shihai, He, Yujie, Lin, Jinzhu, Li, Menglong, Wen, Zhining

“…In pharmaceutical treatment, many non-cardiac drugs carry the risk of prolonging the QT interval, which can lead to fatal cardiac complications such as…”
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Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases by Zhang, Yuwei, Ren, Liang, Wang, Qi, Wen, Zhining, Liu, Chengcheng, Ding, Yi

“…Oral diseases impose a major health burden worldwide and have a profound effect on general health. Dental caries, periodontal diseases, and oral cancers are…”
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Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico by Liu, Yuan, Jing, Runyu, Wen, Zhining, Li, Menglong

“…Toxicogenomics (TGx) is a powerful method to evaluate toxicity and is widely used in both and assays. For TGx, reduction, refinement, and replacement represent…”
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Prediction of Synergistic Drug Combinations for Prostate Cancer by Transcriptomic and Network Characteristics by Li, Shiqi, Zhang, Fuhui, Xiao, Xiuchan, Guo, Yanzhi, Wen, Zhining, Li, Menglong, Pu, Xuemei

“…Prostate cancer (PRAD) is a major cause of cancer-related deaths. Current monotherapies show limited efficacy due to often rapidly emerging resistance…”
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Comparative Analysis for the Performance of Long-Read-Based Structural Variation Detection Pipelines in Tandem Repeat Regions by Guo, Mingkun, Li, Shihai, Zhou, Yifan, Li, Menglong, Wen, Zhining

“…There has been growing recognition of the vital links between structural variations (SVs) and diverse diseases. Research suggests that, with much longer DNA…”
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Uncovering the prognostic gene signatures for the improvement of risk stratification in cancers by using deep learning algorithm coupled with wavelet transform by Zhao, Yiru, Zhou, Yifan, Liu, Yuan, Hao, Yinyi, Li, Menglong, Pu, Xuemei, Li, Chuan, Wen, Zhining

“…The aim of gene expression-based clinical modelling in tumorigenesis is not only to accurately predict the clinical endpoints, but also to reveal the genome…”
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Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map by Wen, Zhining, Wang, Zhijun, Wang, Steven, Ravula, Ranadheer, Yang, Lun, Xu, Jun, Wang, Charles, Zuo, Zhong, Chow, Moses S S, Shi, Leming, Huang, Ying

“…To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM), we used microarrays, bioinformatics and the…”
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Structure-Activity Relationship (SAR) Model for Predicting Teratogenic Risk of Antiseizure Medications in Pregnancy by Using Support Vector Machine by Kang, Liyuan, Duan, Yifei, Chen, Cheng, Li, Shihai, Li, Menglong, Chen, Lei, Wen, Zhining

“…Teratogenicity is one of the main concerns in clinical medications of pregnant women. Prescription of antiseizure medications (ASMs) in women with epilepsy…”
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Differentiation of epilepsy and psychogenic nonepileptic events based on body fluid characteristics by Xia, Yilin, Lai, Wanlin, Li, Shihai, Wen, Zhining, Chen, Lei

“…Objective Differential diagnosis between epileptic seizures and psychogenic nonepileptic events (PNEEs) is a worldwide problem for neurologists. The present…”
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Transcriptome Analysis Identifies Piwi-Interacting RNAs as Prognostic Markers for Recurrence of Prostate Cancer by Zuo, Yuanli, Liang, Yu, Zhang, Jiting, Hao, Yingyi, Li, Menglong, Wen, Zhining, Zhao, Yun

“…Prostate cancer remains the second leading cause of male cancer death, and there is an unmet need for biomarkers to identify patients with such aggressive…”
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Mutation status coupled with RNA-sequencing data can efficiently identify important non-significantly mutated genes serving as diagnostic biomarkers of endometrial cancer by Liu, Keqin, He, Li, Liu, Zhichao, Xu, Junmei, Liu, Yuan, Kuang, Qifan, Wen, Zhining, Li, Menglong

“…Endometrial cancers (ECs) are one of the most common types of malignant tumor in females. Substantial efforts had been made to identify significantly mutated…”
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Expression dynamics and relations with nearby genes of rat transposable elements across 11 organs, 4 developmental stages and both sexes by Dong, Yongcheng, Huang, Ziyan, Kuang, Qifan, Wen, Zhining, Liu, Zhibin, Li, Yizhou, Yang, Yi, Li, Menglong

“…TEs pervade mammalian genomes. However, compared with mice, fewer studies have focused on the TE expression patterns in rat, particularly the comparisons…”
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Predicting disease-associated substitution of a single amino acid by analyzing residue interactions by Li, Yizhou, Wen, Zhining, Xiao, Jiamin, Yin, Hui, Yu, Lezheng, Yang, Li, Li, Menglong

“…The rapid accumulation of data on non-synonymous single nucleotide polymorphisms (nsSNPs, also called SAPs) should allow us to further our understanding of the…”
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Comparative Analysis for the Performance of Variant Calling Pipelines on Detecting the de novo Mutations in Humans by Liang, Yu, He, Li, Zhao, Yiru, Hao, Yinyi, Zhou, Yifan, Li, Menglong, Li, Chuan, Pu, Xuemei, Wen, Zhining

“…Despite of the low occurrence rate in the entire genomes, mutation is proved to be deleterious and will lead to severe genetic diseases via impacting on the…”
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Comprehensive Risk Assessment of Applying Biogas Slurry in Peanut Cultivation by Liu, Qingyu, Zhao, Zixuan, Xue, Zhiping, Li, Ding, Wen, Zhining, Ran, Yi, Mei, Zili, He, Li

“…Biogas slurry, a byproduct of biogas plants, is considered a high-quality bio-organic fertilizer. Despite providing nutrients to crops, biogas slurry may…”
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Advancing Genomics for Drug Development and Safety Evaluation by Liu, Zhichao, Xu, Joshua, Wen, Zhining

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Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles by Li, Zhiguang, Su, Zhenqiang, Wen, Zhining, Shi, Leming, Chen, Tao

“…Several different microarray platforms are available for measuring gene expression. There are disagreements within the microarray scientific community for…”
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Novel feature for catalytic protein residues reflecting interactions with other residues by Li, Yizhou, Li, Gongbing, Wen, Zhining, Yin, Hui, Hu, Mei, Xiao, Jiamin, Li, Menglong

“…Owing to their potential for systematic analysis, complex networks have been widely used in proteomics. Representing a protein structure as a topology network…”
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Abnormal gene expression in cerebellum of Npc1−/− mice during postnatal development by Liao, Guanghong, Wen, Zhining, Irizarry, Kristopher, Huang, Ying, Mitsouras, Katherine, Darmani, Mariam, Leon, Terry, Shi, Leming, Bi, Xiaoning

“…Abstract Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic…”
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