Search Results - "Wen, Zhexing"

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation by Qian, Xuyu, Su, Yijing, Adam, Christopher D., Deutschmann, Andre U., Pather, Sarshan R., Goldberg, Ethan M., Su, Kenong, Li, Shiying, Lu, Lu, Jacob, Fadi, Nguyen, Phuong T.T., Huh, Sooyoung, Hoke, Ahmet, Swinford-Jackson, Sarah E., Wen, Zhexing, Gu, Xiaosong, Pierce, R. Christopher, Wu, Hao, Briand, Lisa A., Chen, H. Isaac, Wolf, John A., Song, Hongjun, Ming, Guo-li

“…Human brain organoids provide unique platforms for modeling development and diseases by recapitulating the architecture of the embryonic brain. However,…”
Get full text

Epigenetic Regulations in Neuropsychiatric Disorders by Kuehner, Janise N, Bruggeman, Emily C, Wen, Zhexing, Yao, Bing

“…Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for proper brain development, function and circuitry formation in the…”
Get full text

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies by Kang, Yunhee, Zhou, Ying, Li, Yujing, Han, Yanfei, Xu, Jie, Niu, Weibo, Li, Ziyi, Liu, Shiying, Feng, Hao, Huang, Wen, Duan, Ranhui, Xu, Tianmin, Raj, Nisha, Zhang, Feiran, Dou, Juan, Xu, Chongchong, Wu, Hao, Bassell, Gary J., Warren, Stephen T., Allen, Emily G., Jin, Peng, Wen, Zhexing

“…Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein (FMRP), an RNA-binding protein that can regulate the translation of…”
Get full text

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen by Xu, Miao, Lee, Emily M, Wen, Zhexing, Cheng, Yichen, Huang, Wei-Kai, Qian, Xuyu, TCW, Julia, Kouznetsova, Jennifer, Ogden, Sarah C, Hammack, Christy, Jacob, Fadi, Nguyen, Ha Nam, Itkin, Misha, Hanna, Catherine, Shinn, Paul, Allen, Chase, Michael, Samuel G, Simeonov, Anton, Huang, Wenwei, Christian, Kimberly M, Goate, Alison, Brennand, Kristen J, Huang, Ruili, Xia, Menghang, Ming, Guo-li, Zheng, Wei, Song, Hongjun, Tang, Hengli

“…A high-throughput screen of preclinical, investigational and FDA-approved drugs identifies compounds that possess antiviral and neuroprotective effects against…”
Get full text

Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders by Michalski, Christina, Wen, Zhexing

“…Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated…”
Get full text

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure by Qian, Xuyu, Nguyen, Ha Nam, Song, Mingxi M., Hadiono, Christopher, Ogden, Sarah C., Hammack, Christy, Yao, Bing, Hamersky, Gregory R., Jacob, Fadi, Zhong, Chun, Yoon, Ki-jun, Jeang, William, Lin, Li, Li, Yujing, Thakor, Jai, Berg, Daniel A., Zhang, Ce, Kang, Eunchai, Chickering, Michael, Nauen, David, Ho, Cheng-Ying, Wen, Zhexing, Christian, Kimberly M., Shi, Pei-Yong, Maher, Brady J., Wu, Hao, Jin, Peng, Tang, Hengli, Song, Hongjun, Ming, Guo-li

“…Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability,…”
Get full text

A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data by Wang, Quan, Chen, Rui, Cheng, Feixiong, Wei, Qiang, Ji, Ying, Yang, Hai, Zhong, Xue, Tao, Ran, Wen, Zhexing, Sutcliffe, James S., Liu, Chunyu, Cook, Edwin H., Cox, Nancy J., Li, Bingshan

“…Genome-wide association studies (GWAS) have identified more than 100 schizophrenia (SCZ)-associated loci, but using these findings to illuminate disease…”
Get full text

Brain Organoids: Studying Human Brain Development and Diseases in a Dish by Xu, Jie, Wen, Zhexing

“…With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human…”
Get full text

Synaptic dysregulation in a human iPS cell model of mental disorders by Wen, Zhexing, Nguyen, Ha Nam, Guo, Ziyuan, Lalli, Matthew A., Wang, Xinyuan, Su, Yijing, Kim, Nam-Shik, Yoon, Ki-Jun, Shin, Jaehoon, Zhang, Ce, Makri, Georgia, Nauen, David, Yu, Huimei, Guzman, Elmer, Chiang, Cheng-Hsuan, Yoritomo, Nadine, Kaibuchi, Kozo, Zou, Jizhong, Christian, Kimberly M., Cheng, Linzhao, Ross, Christopher A., Margolis, Russell L., Chen, Gong, Kosik, Kenneth S., Song, Hongjun, Ming, Guo-li

“…Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology…”
Get full text

Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia by Sullivan, Courtney R., Mielnik, Catharine A., Funk, Adam, O’Donovan, Sinead M., Bentea, Eduard, Pletnikov, Mikhail, Ramsey, Amy J., Wen, Zhexing, Rowland, Laura M., McCullumsmith, Robert E.

“…Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and…”
Get full text

Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases by Lu, Leina, Liu, Xiaoxiao, Huang, Wei-Kai, Giusti-Rodríguez, Paola, Cui, Jian, Zhang, Shanshan, Xu, Wanying, Wen, Zhexing, Ma, Shufeng, Rosen, Jonathan D., Xu, Zheng, Bartels, Cynthia F., Kawaguchi, Riki, Hu, Ming, Scacheri, Peter C., Rong, Zhili, Li, Yun, Sullivan, Patrick F., Song, Hongjun, Ming, Guo-li, Li, Yan, Jin, Fulai

“…Genome-wide mapping of chromatin interactions at high resolution remains experimentally and computationally challenging. Here we used a low-input “easy Hi-C”…”
Get full text

LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia by Ni, Chaoying, Jiang, Wei, Wang, Zhongju, Wang, Zhuo, Zhang, Jian, Zheng, Xianzhen, Liu, Zelin, Ou, Haiyan, Jiang, Tingyun, Liang, Wenquan, Wu, Fengchun, Li, Qiyang, Hou, Yu, Yang, Qiong, Guo, Bo, Liu, Sihan, Li, Shuyun, Li, Shufen, Yang, Ence, Zhu, Xin-Hong, Huang, Xingbing, Wen, Zhexing, Zhao, Cunyou

“…Schizophrenia is a complex genetic disorder, the non-Mendelian features of which are likely complicated by epigenetic factors yet to be elucidated. Here, we…”
Get full text

Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids by Filan, Caroline, Charles, Seleipiri, Casteleiro Costa, Paloma, Niu, Weibo, Cheng, Brian, Wen, Zhexing, Lu, Hang, Robles, Francisco E.

“…Brain organoids provide a unique opportunity to model organ development in a system similar to human organogenesis in vivo. Brain organoids thus hold great…”
Get full text

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins by Yoon, Ki-Jun, Song, Guang, Qian, Xuyu, Pan, Jianbo, Xu, Dan, Rho, Hee-Sool, Kim, Nam-Shik, Habela, Christa, Zheng, Lily, Jacob, Fadi, Zhang, Feiran, Lee, Emily M., Huang, Wei-Kai, Ringeling, Francisca Rojas, Vissers, Caroline, Li, Cui, Yuan, Ling, Kang, Koeun, Kim, Sunghan, Yeo, Junghoon, Cheng, Yichen, Liu, Sheng, Wen, Zhexing, Qin, Cheng-Feng, Wu, Qingfeng, Christian, Kimberly M., Tang, Hengli, Jin, Peng, Xu, Zhiheng, Qian, Jiang, Zhu, Heng, Song, Hongjun, Ming, Guo-li

“…Zika virus (ZIKV) directly infects neural progenitors and impairs their proliferation. How ZIKV interacts with the host molecular machinery to impact…”
Get full text

Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation by Kim, Nam-Shik, Wen, Zhexing, Liu, Jing, Zhou, Ying, Guo, Ziyuan, Xu, Chongchong, Lin, Yu-Ting, Yoon, Ki-Jun, Park, Junhyun, Cho, Michelle, Kim, Minji, Wang, Xinyuan, Yu, Huimei, Sakamuru, Srilatha, Christian, Kimberly M., Hsu, Kuei-sen, Xia, Menghang, Li, Weidong, Ross, Christopher A., Margolis, Russell L., Lu, Xin-Yun, Song, Hongjun, Ming, Guo-li

“…We previously identified a causal link between a rare patient mutation in DISC1 (disrupted-in-schizophrenia 1) and synaptic deficits in cortical neurons…”
Get full text

TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response by Ho, Ming-Fen, Zhang, Cheng, Zhang, Lingxin, Wei, Lixuan, Zhou, Ying, Moon, Irene, Geske, Jennifer R., Choi, Doo-Sup, Biernacka, Joanna, Frye, Mark, Wen, Zhexing, Karpyak, Victor M., Li, Hu, Weinshilboum, Richard

“…We previously reported that SNPs near TSPAN5 were associated with plasma serotonin (5-HT) concentrations which were themselves associated with selective…”
Get full text

APOE expression and secretion are modulated by mitochondrial dysfunction by Wynne, Meghan E, Ogunbona, Oluwaseun, Lane, Alicia R, Gokhale, Avanti, Zlatic, Stephanie A, Xu, Chongchong, Wen, Zhexing, Duong, Duc M, Rayaprolu, Sruti, Ivanova, Anna, Ortlund, Eric A, Dammer, Eric B, Seyfried, Nicholas T, Roberts, Blaine R, Crocker, Amanda, Shanbhag, Vinit, Petris, Michael, Senoo, Nanami, Kandasamy, Selvaraju, Claypool, Steven Michael, Barrientos, Antoni, Wingo, Aliza, Wingo, Thomas S, Rangaraju, Srikant, Levey, Allan I, Werner, Erica, Faundez, Victor

“…Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine…”
Get full text

Role of Astrocytes in Major Neuropsychiatric Disorders by Zhang, Xiaolu, Alnafisah, Rawan S., Hamoud, Abdul-Rizaq A., Shukla, Rammohan, Wen, Zhexing, McCullumsmith, Robert E., O’Donovan, Sinead M.

“…Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to…”
Get full text

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model by Murai, Kiyohito, Sun, Guoqiang, Ye, Peng, Tian, E., Yang, Su, Cui, Qi, Sun, Guihua, Trinh, Daniel, Sun, Olivia, Hong, Teresa, Wen, Zhexing, Kalkum, Markus, Riggs, Arthur D., Song, Hongjun, Ming, Guo-li, Shi, Yanhong

“…Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its…”
Get full text

Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review by Grabowska, Monika E., Huang, Annabelle, Wen, Zhexing, Li, Bingshan, Wei, Wei-Qi

“…Background: Alzheimer’s disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought…”
Get full text