Search Results - "Wen, Xingzhao"

Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration by Sun, Hao, Wen, Xingzhao, Li, Hongyi, Wu, Peihui, Gu, Minghui, Zhao, Xiaoyi, Zhang, Ziji, Hu, Shu, Mao, Guping, Ma, Ruofan, Liao, Weiming, Zhang, Zhiqi

“…The heterogeneity of meniscus cells and the mechanism of meniscus degeneration is not well understood. Here, single-cell RNA sequencing (scRNA-seq) was used to…”
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Genome-wide colocalization of RNA–DNA interactions and fusion RNA pairs by Yan, Zhangming, Huang, Norman, Wu, Weixin, Chen, Weizhong, Jiang, Yiqun, Chen, Jingyao, Huang, Xuerui, Wen, Xingzhao, Xu, Jie, Jin, Qiushi, Zhang, Kang, Chen, Zhen, Chien, Shu, Zhong, Sheng

“…Fusion transcripts are used as biomarkers in companion diagnoses. Although more than 15,000 fusion RNAs have been identified from diverse cancer types, few…”
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MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2 by Hu, Shu, Zhao, Xiaoyi, Mao, Guping, Zhang, Ziji, Wen, Xingzhao, Zhang, Chengyun, Liao, Weiming, Zhang, Zhiqi

“…MicroRNAs (miRNAs, miR) play a key role in the pathogenesis of osteoarthritis (OA). Few studies have examined the regulatory role of P21-activated kinases…”
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Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells by Calandrelli, Riccardo, Wen, Xingzhao, Charles Richard, John Lalith, Luo, Zhifei, Nguyen, Tri C., Chen, Chien-Ju, Qi, Zhijie, Xue, Shuanghong, Chen, Weizhong, Yan, Zhangming, Wu, Weixin, Zaleta-Rivera, Kathia, Hu, Rong, Yu, Miao, Wang, Yuchuan, Li, Wenbo, Ma, Jian, Ren, Bing, Zhong, Sheng

“…The interphase genome is dynamically organized in the nucleus and decorated with chromatin-associated RNA (caRNA). It remains unclear whether the genome…”
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Whole-Transcriptome Sequence of Degenerative Meniscus Cells Unveiling Diagnostic Markers and Therapeutic Targets for Osteoarthritis by Jiang, Zongrui, Du, Xue, Wen, Xingzhao, Li, Hongyi, Zeng, Anyu, Sun, Hao, Hu, Shu, He, Qing, Liao, Weiming, Zhang, Zhiqi

“…Meniscus plays an important role in joint homeostasis. Tear or degeneration of meniscus might facilitate the process of knee osteoarthritis (OA). Hence, to…”
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The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-related miRNAs by Zhao, Xiaoyi, Meng, Fangang, Hu, Shu, Yang, Zibo, Huang, Hao, Pang, Rui, Wen, Xingzhao, Kang, Yan, Zhang, Zhiqi

“…Knee osteoarthritis (KOA) is a highly prevalent disabling joint disease in aged people. Progressive cartilage degradation is the hallmark of KOA, but its…”
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Inhibition of miR-490-5p Promotes Human Adipose-Derived Stem Cells Chondrogenesis and Protects Chondrocytes via the PITPNM1/PI3K/AKT Axis by Li, Hongyi, Zhao, Xiaoyi, Wen, Xingzhao, Zeng, Anyu, Mao, Guping, Lin, Ruifu, Hu, Shu, Liao, Weiming, Zhang, Zhiqi

“…MicroRNAs (miRNAs) play a pivotal role in cartilage development and homeostasis in osteoarthritis (OA). While the fundamental roles of miRNAs in cartilage…”
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Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner by Sun, Hao, Liu, Fangzhou, Lin, Zhencan, Jiang, Zongrui, Wen, Xingzhao, Xu, Jie, Zhang, Zhiqi, Ma, Ruofan

“…The mechanisms of meniscus fibrosis and novel ways to enhance fibrosis is unclear. This work reveals human meniscus fibrosis initiated at E24 weeks. Smooth…”
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Meniscus cell lysate induces mitochondrial dysfunction of fibroblast-like synoviocytes via upregulating ANT3 in osteoarthritis: aNT3 is a potentially important novel mediator and drug target in osteoarthritis by Du, Xue, Jiang, Zongrui, Fang, Guibin, Liu, Ruonan, Wen, Xingzhao, Wu, Yinjuan, Hu, Shu, Zhang, Zhiqi

“…Aims This study aimed to investigate the role and mechanism of meniscal cell lysate (MCL) in fibroblast-like synoviocytes (FLSs) and osteoarthritis (OA)…”
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Functional organization of the maternal and paternal human 4D Nucleome by Lindsly, Stephen, Jia, Wenlong, Chen, Haiming, Liu, Sijia, Ronquist, Scott, Chen, Can, Wen, Xingzhao, Stansbury, Cooper, Dotson, Gabrielle A., Ryan, Charles, Rehemtulla, Alnawaz, Omenn, Gilbert S., Wicha, Max, Li, Shuai Cheng, Muir, Lindsey, Rajapakse, Indika

“…Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific…”
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Alu transposable elements rewire enhancer-promoter network through RNA pairing by Wen, Xingzhao, Zhong, Sheng

“…A recent study by Liang et al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify…”
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MicroRNA-320c inhibits development of osteoarthritis through downregulation of canonical Wnt signaling pathway by Hu, Shu, Mao, Guping, Zhang, Ziji, Wu, Peihui, Wen, Xingzhao, Liao, Weiming, Zhang, Zhiqi

“…Osteoarthritis (OA) is a leading cause of deformity in aging people. Emerging evidence suggests that microRNAs and Wnt signaling pathway are associated with…”
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MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway by Wen, Xingzhao, Li, Hongyi, Sun, Hao, Zeng, Anyu, Lin, Ruifu, Zhao, Jing, Zhang, Zhiqi

“…This study aimed to explore the functions of miR-455-3p, PTEN, and PI3K/AKT pathway in osteoarthritis. We used the human bone marrow stem cell (BMSC), healthy…”
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Single-cell multiplex chromatin and RNA interactions in ageing human brain by Wen, Xingzhao, Luo, Zhifei, Zhao, Wenxin, Calandrelli, Riccardo, Nguyen, Tri C., Wan, Xueyi, Charles Richard, John Lalith, Zhong, Sheng

“…Dynamically organized chromatin complexes often involve multiplex chromatin interactions and sometimes chromatin-associated RNA 1 – 3 . Chromatin complex…”
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Inferring single cell expression profiles from overlapped pooling sequencing data with compressed sensing strategy by Huang, Mengting, Yang, Yixuan, Wen, Xingzhao, Xu, Weiqiang, Lu, Na, Sun, Xiao, Tu, Jing, Lu, Zuhong

“…Abstract Though single cell RNA sequencing (scRNA-seq) technologies have been well developed, the acquisition of large-scale single cell expression data may…”
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Revealing protein-protein interactions at the transcriptome scale by sequencing by Johnson, Kara L., Qi, Zhijie, Yan, Zhangming, Wen, Xingzhao, Nguyen, Tri C., Zaleta-Rivera, Kathia, Chen, Chien-Ju, Fan, Xiaochen, Sriram, Kiran, Wan, Xueyi, Chen, Zhen Bouman, Zhong, Sheng

“…We describe PROPER-seq (protein-protein interaction sequencing) to map protein-protein interactions (PPIs) en masse. PROPER-seq first converts transcriptomes…”
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Hyaluronan size alters chondrogenesis of mesenchymal stem cells cultured on tricalcium phosphate‐collagen‐hyaluronan scaffolds by Meng, Fangang, Yang, Zibo, Long, Dianbo, Gu, Minghui, Shang, Mei, Zeng, Anyu, Wen, Xingzhao, Xue, Yueran, Zhao, Xiaoyi, He, Aishan

“…Hyaluronan (HA) provides a favorable environment for chondrogenesis of bone marrow mesenchymal stem cells (BMSCs). A previous report from our group indicated…”
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Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP) by Jain, Sanjay, Pei, Liming, Spraggins, Jeffrey M., Angelo, Michael, Carson, James P., Gehlenborg, Nils, Ginty, Fiona, Gonçalves, Joana P., Hagood, James S., Hickey, John W., Kelleher, Neil L., Laurent, Louise C., Lin, Shin, Lin, Yiing, Liu, Huiping, Naba, Alexandra, Nakayasu, Ernesto S., Qian, Wei-Jun, Radtke, Andrea, Robson, Paul, Stockwell, Brent R., Van de Plas, Raf, Vlachos, Ioannis S., Zhou, Mowei, Börner, Katy, Snyder, Michael P.

“…The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying…”
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Higher Pelvic Incidence Was Associated with a Higher Risk of Sagittal Malposition of Femoral Component and Poor Outcomes of Primary Total Knee Arthroplasty: A Retrospective Cohort Analysis by Li, Hongyi, Zhu, Fei, Liao, Shufen, Wang, Xiangjiang, Zhong, Yanlin, Wen, Xingzhao, Zhao, Xiaoyi, Liao, Weiming, Zhang, Zhiqi

“…Spine-pelvis-lower extremity sagittal alignment is regarded as a global sagittal balance. Currently, there are few studies evaluating the pelvic and femoral…”
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Revealing protein-protein interactions at the transcriptome scale by sequencing by Johnson, Kara L., Qi, Zhijie, Yan, Zhangming, Wen, Xingzhao, Nguyen, Tri C., Zaleta-Rivera, Kathia, Chen, Chien-Ju, Fan, Xiaochen, Sriram, Kiran, Wan, Xueyi, Chen, Zhen Bouman, Zhong, Sheng

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