Search Results - "Welting, T J M"

Reporter gene comparison demonstrates interference of complex body fluids with secreted luciferase activity by Neefjes, M., Housmans, B. A. C., van den Akker, G. G. H., van Rhijn, L. W., Welting, T. J. M., van der Kraan, P. M.

“…Reporter gene assays are widely used to study cellular signaling and transcriptional activity. Few studies describe the use of reporter genes for studying…”
Get full text

Novel Radiopaque Ultrahigh Molecular Weight Polyethylene Sublaminar Wires in a Growth-Guidance System for the Treatment of Early-Onset Scoliosis: Feasibility in a Large Animal Study by Bogie, Rob, Roth, A K, de Faber, S, de Jong, J. J A, Welting, T. J M, Willems, P C, Arts, J J, van Rhijn, L W

“…STUDY DESIGN.In vivo analysis in an ovine model. OBJECTIVE.To evaluate the feasibility of radiopaque ultrahigh molecular weight polyethylene (UHMWPE)…”
Get full text

Tissue-engineered constructs: the effect of scaffold architecture in osteochondral repair by Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., Riesle, J., van Rhijn, L. W., Kuijer, R.

“…Cartilage has a poor regenerative capacity. Tissue‐engineering approaches using porous scaffolds seeded with chondrocytes may improve cartilage repair. The aim…”
Get full text

Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures by Caron, M.M.J, Emans, P.J, Coolsen, M.M.E, Voss, L, Surtel, D.A.M, Cremers, A, van Rhijn, L.W, Welting, T.J.M

“…Summary Objective Three-dimensional (3D) cultures are widely used to redifferentiate chondrocytes. However, the rationale behind the choice for 3D above…”
Get full text

Identification of tissue-dependent proteins in knee OA synovial fluid by Timur, U.T., Jahr, H., Anderson, J., Green, D.C., Emans, P.J., Smagul, A., van Rhijn, L.W., Peffers, M.J., Welting, T.J.M.

“…For many proteins from osteoarthritic synovial fluid, their intra-articular tissue of origin remains unknown. In this study we performed comparative proteomics…”
Get full text

Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling by Housmans, B.A.C., Neefjes, M., Surtel, D.A.M., Vitík, M., Cremers, A., van Rhijn, L.W., van der Kraan, P.M., van den Akker, G.G.H., Welting, T.J.M.

“…Alterations in the composition of synovial fluid have been associated with adverse effects on cartilage integrity and function. Here, we examined the…”
Get full text

Unravelling the Basic Calcium Phosphate crystal-dependent chondrocyte protein secretome; a role for TGF-β signaling by Stassen, R.H.M.J., van den Akker, G.G.H., Surtel, D.A.M., Housmans, B.A.C., Cremers, A., Caron, M.M.J., Smagul, A., Peffers, M.J., van Rhijn, L.W., Welting, T.J.M.

“…Basic Calcium Phosphate (BCP) crystals play an active role in the progression of osteoarthritis (OA). However, the cellular consequences remain largely…”
Get full text

Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes by Housmans, B.A.C., van den Akker, G.G.H., Neefjes, M., Timur, U.T., Cremers, A., Peffers, M.J., Caron, M.M.J., van Rhijn, L.W., Emans, P.J., Boymans, T.A.E.J., Feczko, P.Z., van der Kraan, P.M., Welting, T.J.M.

“…Since the joint microenvironment and tissue homeostasis are highly dependent on synovial fluid, we aimed to compare the essential chondrocyte signaling…”
Get full text

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7 by Caron, M.M.J, Emans, P.J, Cremers, A, Surtel, D.A.M, Coolsen, M.M.E, van Rhijn, L.W, Welting, T.J.M

“…Summary Objective Bone morphogenic protein (BMP)-2 and BMP-7 are clinically approved and their recombinant proteins are used for bone tissue regenerative…”
Get full text

Development of a cyclic-inverso AHSG/Fetuin A-based peptide for inhibition of calcification in osteoarthritis by van den Akker, G.G.H., Steijns, J.S.J.J., Stassen, R.H.M.J., Wasilewski, G.B., Peeters, L.C.W., Wijnands, K.A.P., Schurgers, L.J., Caron, M.M.J., van Rhijn, L.W., Welting, T.J.M.

“…Ectopic calcification is an important contributor to chronic diseases, such as osteoarthritis. Currently, no effective therapies exist to counteract…”
Get full text

Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis by Chabronova, A., van den Akker, G.G.H., Housmans, B.A.C., Caron, M.M.J., Cremers, A., Surtel, D.A.M., Wichapong, K., Peffers, M.M.J., van Rhijn, L.W., Marchand, V., Motorin, Y., Welting, T.J.M.

“…Osteoarthritis-related cartilage extracellular matrix remodeling is dependent on changes in chondrocyte protein expression. Yet, the role of ribosomes in…”
Get full text

Celecoxib-mediated reduction of prostanoid release in Hoffa's fat pad from donors with cartilage pathology results in an attenuated inflammatory phenotype by Timur, U.T., Caron, M.M.J., Bastiaansen-Jenniskens, Y.M., Welting, T.J.M., van Rhijn, L.W., van Osch, G.J.V.M., Emans, P.J.

“…The Hoffa's fat pad (HFP) is an intra-articular adipose tissue which is situated under and behind the patella. It contains immune cells next to adipocytes and…”
Get full text

Dysplasia epiphysealis hemimelica: A histological comparative study with osteochondromas by Stevens, J., Welting, T. J. M., Witlox, A. M., van Rhijn, L. W., Staal, H. M.

“…Purpose Dysplasia epiphysealis hemimelica (DEH) is a rare developmental disorder resulting in epiphyseal overgrowth. Based on histological appearance, it is…”
Get full text

Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment by Laagland, LT, Bach, FC, Riemers, FM, Erdmann, G, Braun, TS, van den Akker, GGH, Schmitz, TC, Creemers, LB, Sachse, C, Le Maitre, CL, Welting, TJM, Ito, K, Templin, MF, Tryfonidou, MA

“…Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the…”
Get full text

Impairment of the chondrogenic phase of endochondral ossification in vivo by inhibition of cyclooxygenase-2 by Janssen, M P, Caron, M M, van Rietbergen, B, Surtel, D A, van Rhijn, L W, Welting, T J, Emans, P J

“…Many studies have reported on the effects of cyclooxygenase-2 (COX-2) inhibition on osteogenesis. However, far less is known about the effects of COX-2…”
Get full text

Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification by Welting, T J M, Caron, M M J, Emans, P J, Janssen, M P F, Sanen, K, Coolsen, M M E, Voss, L, Surtel, D A M, Cremers, A, Voncken, J W, van Rhijn, L W

“…Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone…”
Get full text

Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex by Welting, Tim J. M., van Venrooij, Walther J., Pruijn, Ger J. M.

“…The eukaryotic ribonuclease for mitochondrial RNA processing (RNase MRP) is mainly located in the nucleoli and belongs to the small nucleolar ribonucleoprotein…”
Get full text

Tissue-engineered constructs: the effect of scaffold architecture in osteochondral repair: Role of scaffold architecture in osteochondral repair by Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., Riesle, J., van Rhijn, L. W., Kuijer, R.

Get full text

Chimeric Arteriviruses Generated by Swapping of the M Protein Ectodomain Rule Out a Role of This Domain in Viral Targeting by Verheije, M.H., Welting, T.J.M., Jansen, H.T., Rottier, P.J.M., Meulenberg, J.J.M.

“…Arteriviruses are enveloped, positive-strand RNA viruses for which the two major envelope proteins GP 5 and M occur as disulfide-linked heterodimers. These…”
Get full text