The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis

T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has yet to be established. The aim...

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Bibliographic Details
Published in:	International journal of cardiology Vol. 260; pp. 184 - 190
Main Authors:	Simons, K.H., Aref, Z., Peters, H.A.B., Welten, S.P., Nossent, A.Y., Jukema, J.W., Hamming, J.F., Arens, R., de Vries, M.R., Quax, P.H.A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2018
Subjects:	Angiogenesis Animals Arteriogenesis CD27 Ligand - deficiency CD27 Ligand - physiology CD70 Co-stimulation Hindlimb - blood supply Hindlimb - diagnostic imaging Ischemia - diagnostic imaging Ischemia - physiopathology Laser-Doppler Flowmetry - methods Male Mice Mice, Inbred C57BL Mice, Knockout Neovascularization Neovascularization, Pathologic - diagnostic imaging Neovascularization, Pathologic - physiopathology Neovascularization, Physiologic - physiology T cell T-Lymphocytes - physiology Tumor Necrosis Factor Receptor Superfamily, Member 7 - deficiency Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology Arteriogenesis Angiogenesis Neovascularization Co-stimulation CD70 T cell
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Summary:	T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has yet to be established. The aim of this study was to investigate the role T cell co-stimulation and inhibition in angiogenesis, arteriogenesis and vasculogenesis. Hind limb ischemia was induced by double ligation of the left femoral artery in mice and blood flow recovery was measured with Laser Doppler Perfusion Imaging in control, CD70−/−, CD80/86−/−, CD70/80/86−/− and CTLA4+/− mice. Blood flow recovery was significantly impaired in mice lacking CD70 compared to control mice, but was similar in CD80/86−/−, CTLA4+/− and control mice. Mice lacking CD70 showed impaired vasculogenesis, since the number of pre-existing collaterals was reduced as observed in the pia mater compared to control mice. In vitro an impaired capability of vascular smooth muscle cells (VSMC) to activate T cells was observed in VSMC lacking CD70. Furthermore, CD70−/−, CD80/86−/− and CD70/80/86−/− mice showed reduced angiogenesis in the soleus muscle 10 days after ligation. Arteriogenesis was also decreased in CD70−/− compared to control mice 10 and 28 days after surgery. The present study is the first to describe an important role for T cell activation via co-stimulation in angiogenesis, arteriogenesis and vasculogenesis, where the CD27-CD70 T cell co-stimulation pathway appears to be the most important co-stimulation pathway in pre-existing collateral formation and post-ischemic blood flow recovery, by arteriogenesis and angiogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0167-5273 1874-1754
DOI:	10.1016/j.ijcard.2018.02.015