Search Results - "Welsh, Michael"

Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response by Welsh, Michael

“…The vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly…”
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The Felicitous Success of the Subsection Molecular Oncology of International Journal of Molecular Sciences by Welsh, Michael

“…The evolvement of the newly started subsection IJMS molecular oncology is discussed. The breadth and depth of the journal articles is alluded to. A bright…”
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The arc of discovery, from the description of cystic fibrosis to effective treatments by Welsh, Michael J

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Origins of Cystic Fibrosis Lung Disease by Stoltz, David A, Meyerholz, David K, Welsh, Michael J

“…Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator undermine many host defense systems by inhibiting the function of…”
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Chemical probes of quorum sensing: from compound development to biological discovery by Welsh, Michael A., Blackwell, Helen E.

“…Bacteria can utilize chemical signals to coordinate the expression of group-beneficial behaviors in a method of cell–cell communication called quorum sensing…”
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Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa by Welsh, Michael A, Blackwell, Helen E

“…Nutritional cues differentially influence the activities of the three quorum sensing (QS) circuits-Las, Rhl, and Pqs-in the pathogen Pseudomonas aeruginosa. A…”
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Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases by Cai, Rong, Zhang, Yu, Simmering, Jacob E, Schultz, Jordan L, Li, Yuhong, Fernandez-Carasa, Irene, Consiglio, Antonella, Raya, Angel, Polgreen, Philip M, Narayanan, Nandakumar S, Yuan, Yanpeng, Chen, Zhiguo, Su, Wenting, Han, Yanping, Zhao, Chunyue, Gao, Lifang, Ji, Xunming, Welsh, Michael J, Liu, Lei

“…Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and…”
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Acidic pH increases airway surface liquid viscosity in cystic fibrosis by Tang, Xiao Xiao, Ostedgaard, Lynda S, Hoegger, Mark J, Moninger, Thomas O, Karp, Philip H, McMenimen, James D, Choudhury, Biswa, Varki, Ajit, Stoltz, David A, Welsh, Michael J

“…Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs…”
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Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease by Simmering, Jacob E, Welsh, Michael J, Liu, Lei, Narayanan, Nandakumar S, Pottegård, Anton

“…Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and…”
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Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala by Du, Jianyang, Reznikov, Leah R., Price, Margaret P., Zha, Xiang-ming, Lu, Yuan, Moninger, Thomas O., Wemmie, John A., Welsh, Michael J.

“…Stimulating presynaptic terminals can increase the proton concentration in synapses. Potential receptors for protons are acid-sensing ion channels (ASICs), Na…”
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ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster by Lu, Beika, LaMora, Angela, Sun, Yishan, Welsh, Michael J, Ben-Shahar, Yehuda

“…Insects utilize diverse families of ion channels to respond to environmental cues and control mating, feeding, and the response to threats. Although…”
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Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes by Welsh, Michael A, Eibergen, Nora R, Moore, Joseph D, Blackwell, Helen E

“…The opportunistic pathogen Pseudomonas aeruginosa uses three interwoven quorum-sensing (QS) circuitsLas, Rhl, and Pqsto regulate the global expression of…”
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Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis by Hoegger, Mark J., Fischer, Anthony J., McMenimen, James D., Ostedgaard, Lynda S., Tucker, Alex J., Awadalla, Maged A., Moninger, Thomas O., Michalski, Andrew S., Hoffman, Eric A., Zabner, Joseph, Stoltz, David A., Welsh, Michael J.

“…Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. Advanced CF is…”
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Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions by Miller, Aaron C., Comellas, Alejandro P., Hornick, Douglas B., Stoltz, David A., Cavanaugh, Joseph E., Gerke, Alicia K., Welsh, Michael J., Zabner, Joseph, Polgreen, Philip M.

“…Autosomal recessive diseases, such as cystic fibrosis (CF), require inheritance of 2 mutated genes. However, some studies indicate that CF carriers are at…”
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Use of Glycolysis‐Enhancing Drugs and Risk of Parkinson's Disease by Simmering, Jacob E., Welsh, Michael J., Schultz, Jordan, Narayanan, Nandakumar S.

“…Background Terazosin (TZ) and closely related α1‐adrenergic receptor antagonists (doxazosin [DZ] and alfuzosin [AZ]) enhance glycolysis and reduce…”
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Airway acidification initiates host defense abnormalities in cystic fibrosis mice by Shah, Viral S., Meyerholz, David K., Tang, Xiao Xiao, Reznikov, Leah, Alaiwa, Mahmoud Abou, Ernst, Sarah E., Karp, Philip H., Wohlford-Lenane, Christine L., Heilmann, Kristopher P., Leidinger, Mariah R., Allen, Patrick D., Zabner, Joseph, McCray, Paul B., Ostedgaard, Lynda S., Stoltz, David A., Randak, Christoph O., Welsh, Michael J.

“…Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans…”
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Motile Cilia of Human Airway Epithelia Are Chemosensory by Shah, Alok S, Ben-Shahar, Yehuda, Moninger, Thomas O, Kline, Joel N, Welsh, Michael J

“…Cilia are microscopic projections that extend from eukaryotic cells. There are two general types of cilia; primary cilia serve as sensory organelles, whereas…”
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Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases by Welsh, Michael A, Schaefer, Kaitlin, Taguchi, Atsushi, Kahne, Daniel, Walker, Suzanne

“…The bacterial cell wall is composed of peptidoglycan, and its biosynthesis is an established target for antibiotics. Peptidoglycan is assembled from a…”
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Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach by Manna, Uttam, Raman, Namrata, Welsh, Michael A., Zayas-Gonzalez, Yashira M., Blackwell, Helen E., Palecek, Sean P., Lynn, David M.

“…Many types of slippery liquid‐infused porous surfaces (‘SLIPS’) can resist adhesion and colonization by microorganisms. These ‘slippery’ materials thus offer…”
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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung by Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph

“…In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface…”
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