Search Results - "Welsh, K. M"

Effect of cyclic pneumatic soft tissue compression on simulated distal radius fractures by Challis, M J, Welsh, M K, Jull, G A, Crawford, R

“…We investigated the effect of pneumatic pressure applied to the proximal musculature of the sheep foreleg on load at the site of a transverse osteotomy of the…”
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Isolation and Characterization of the Escherichia coli mutL Gene Product by Grilley, M, Welsh, K M, Su, S S, Modrich, P

“…The Escherichia coli mutL gene product has been purified to near homogeneity from an overproducing clone. The mutL locus encodes a polypeptide of 70,000…”
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Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis by Welsh, K M, Trach, K A, Folger, C, Hoch, J A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Isolation and characterization of the Escherichia coli mutH gene product by Welsh, K M, Lu, A L, Clark, S, Modrich, P

“…The Escherichia coli mutH gene product has been isolated in near homogeneous form using an in vitro complementation assay for DNA mismatch correction (Lu,…”
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Salivary cortisol changes in humans after winning or losing a dominance contest depend on implicit power motivation by Wirth, Michelle M., Welsh, Kathryn M., Schultheiss, Oliver C.

“…In two studies, one with an all-male German sample and the other with a mixed-sex U.S. sample, subjects competed in pairs on reaction time-based cognitive…”
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Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones by Webber, Stephen E, Bleckman, Ted M, Attard, John, Deal, Judith G, Kathardekar, Vinit, Welsh, Katherine M, Webber, Stephanie, Janson, Cheryl A, Matthews, David A

“…The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out…”
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Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase by Varney, Michael D, Marzoni, Gifford P, Palmer, Cindy L, Deal, Judith G, Webber, Stephanie, Welsh, Katherine M, Bacquet, Russell J, Bartlett, Charlotte A, Morse, Catharine A

“…The X-ray crystal-structure-based design, synthesis, and biological activity of a novel family of benz[cd]indole-containing inhibitors of thymidylate synthase…”
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Synthesis and Biological Evaluation of Novel 2,6-Diaminobenz[cd]indole Inhibitors of Thymidylate Synthase Using the Protein Structure as a Guide by Varney, Michael D, Palmer, Cindy L, Deal, Judith G, Webber, Stephanie, Welsh, Katherine M, Bartlett, Charlotte A, Morse, Catharine A, Smith, Ward W, Janson, Cheryl A

“…The design, synthesis, and biochemical and biological evaluations of a novel series of 2,6-diaminobenz[cd]indole-containing inhibitors of human thymidylate…”
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Thermodynamics, kinetics, and mechanism in yeast inorganic pyrophosphatase catalysis of inorganic pyrophosphate:inorganic phosphate equilibration by Springs, B, Welsh, K. M, Cooperman, B. S

“…We have developed two methods for quantitatively measuring inorganic pyrophosphate (PPi) in the presence of 10(3)--10(4) molar excesses of inorganic phosphate…”
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Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis by Reich, Siegfried H, Fuhry, Mary Ann M, Nguyen, Dzuy, Pino, Mark J, Welsh, Katherine M, Webber, Stephanie, Janson, Cheryl A, Jordan, Steven R, Matthews, David A

“…Antifolate inhibitors of thymidylate synthase (TS) have primarily been based on the structure of folic acid. This paper describes the identification and…”
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Alteration of the metastatic potential of line 1 lung carcinoma cells: opposite effects of class I antigen induction by interferons versus DMSO or gene transfection by Cerosaletti, K M, Blieden, T M, Harwell, L W, Welsh, K M, Frelinger, J G, Lord, E M

“…Class I antigens are necessary for the recognition of tumor cells by cytotoxic T lymphocytes (CTL). The line 1 lung carcinoma is a spontaneous murine tumor…”
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Evidence that catalysis by yeast inorganic pyrophosphatase proceeds by direct phosphoryl transfer to water and not via a phosphoryl enzyme intermediate by Gonzalez, Marcel A, Webb, Martin R, Welsh, Katherine M, Cooperman, Barry S

“…In this work, we show that adenosine 5'-O-(3-thiotriphosphate) (ATP gamma S) is a substrate for yeast inorganic pyrophosphatase (PPase) (EC 3.6.1.1) and…”
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The Effect of Recombinant Human Growth Hormone on Wound Healing in Normal Individuals by WELSH, KATHLEEN M., LAMIT, MARGARET, MORHENN, VERA B.

“…Growth hormone therapy has been suggested to speed wound healing in postoperative patients and in patients with severe burns. This study was undertaken to…”
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Asthma clinical pathway: an interdisciplinary approach to implementation in the inpatient setting by Welsh, K M, Magnusson, M, Napoli, L

“…Asthma is a leading cause of admission to the pediatric inpatient setting. Despite advances in the treatment of this chronic condition, morbidity and mortality…”
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Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase by Jones, Terence R, Webber, Stephen E, Varney, Michael D, Reddy, M. Rami, Lewis, Kathleen K, Kathardekar, Vinit, Mazdiyasni, Hormoz, Deal, Judith, Nguyen, Dzuy, Welsh, Katharine M, Webber, Stephanie, Johnston, Amanda, Matthews, David A, Smith, Ward W, Janson, Cheryl A, Bacquet, Russell J, Howland, Eleanor F, Booth, Carol L. J, Herrmann, Steven M, Ward, Robert W, White, Jennifer, Bartlett, Charlotte A, Morse, Cathy A

“…Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate…”
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Characterization of membrane-bound nicotinamide adenine dinucleotide glycohydrolase of Vibrio cholerae by Fernandes, P B, Welsh, K M, Bayer, M E

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Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase by Reddy, M. Rami, Bacquet, Russell J., Zichi, Dominic, Matthews, David A., Welsh, Katherine M., Jones, Terence R., Freer, Stephan

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The photochemistry of matrix-isolated di-tert-butyldiazidosilane. Observation of di-tert-butylsilylene and N,N'-di-tert-butylsilanediimine by Welsh, Kevin M, Michl, Josef, West, Robert

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Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis by Perego, M, Hanstein, C, Welsh, K M, Djavakhishvili, T, Glaser, P, Hoch, J A

“…The initiation of sporulation in B. subtilis is regulated by the Spo0A transcription factor, which is activated by phosphorylation to control developmental…”
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Yeast inorganic pyrophosphatase. A model for active-site structure based on 113Cd2+ and 31P NMR studies by WELSH, K. M, COOPERMAN, B. S

“…Equilibrium dialysis and 113Cd2+ NMR studies in the presence of inorganic phosphate (Pi) provide clear evidence for the existence of four well-defined Cd2+…”
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