Search Results - "Welsh, Clement J"

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation by Cabot, Myles C., Welsh, Clement J., Cao, Hui-ting, Chabbott, Holly

“…Agonist-induced degradation of phosphatidylcholine (PC) is of interest as this pathway of diacylglycerol (DG) generation may provide added opportunities for…”
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Formation of mitochondrial phospholipid adducts by nephrotoxic cysteine conjugate metabolites by Hayden, Patrick J, Welsh, Clement J, Yang, Yun, Schaefer, William H, Ward, Anthony J. I, Stevens, James L

“…Nephrotoxic cysteine conjugates derived from a variety of halogenated alkenes are enzymatically activated via the beta-lyase pathway to yield reactive…”
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Platelet-Derived Growth Factor Activates Phospholipase D and Chemotactic Responses in Vascular Smooth Muscle Cells by Clement J. Welsh, Karen Schmeichel, McBride, Kevin

“…Platelet-derived growth factor (BB dimer; PDGF-BB) stimulates a mitogenic response in A-10 vascular smooth muscle cells. In addition, PDGF-BB stimulates…”
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Fatty acid metabolism in phorbol ester-differentiating human leukemia cells by Cabot, M C, Welsh, C J

“…Human promyelocytic leukemia cells (HL-60) undergo differentiation when treated with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). As the…”
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Alterations in lipid metabolism induced by 12-O-tetradecanoylphorbol-13-acetate in differentiating human myeloid leukemia cells by Cabot, M C, Welsh, C J, Callaham, M F, Huberman, E

“…Several aspects of lipid metabolism were evaluated in differentiating human myeloid leukemia (HL-60) cells after treatment with the tumor promoter…”
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Hormonal regulation of preputial gland function in male Microtus montanus, the montane vole by Rowsemitt, C N, Welsh, C J, Kuehl, M C, Moore, R E, Jackson, L L

“…1. Preputial gland function in male Microtus montanus is androgen-dependent, both in terms of preputial weights and in the production of a series of lipids…”
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Effects of Proximate Cholesterol Precursors and Steroid Hormones on Mouse Myeloma Growth in Serum-Free Medium by Sato, J. Denry, Hui-Ting Cao, Kayada, Yoshiaki, Cabot, Myles C., Sato, Gordon H., Okamoto, Tetsuji, Clement J. Welsh

“…The proximate cholesterol precursors lathosterol, 7-dehydrocholesterol and desmosterol supported the growth of NS-1 and X63 mouse myeloma cells. These cells…”
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Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism by Critchfield, J W, Welsh, C J, Phang, J M, Yeh, G C

“…Since P-glycoprotein (P-gp) in normal tissues may serve as a cellular defense mechanism against naturally occurring xenobiotics, we considered whether…”
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Assays for investigations of signal transduction mechanisms involving phospholipase D: mass measurements of phosphatidate, phosphatidylethanol, and diacylglycerol in cultured cells by Welsh, C J, Schmeichel, K

“…With the intent of achieving a better understanding of agonist-induced phospholipase D activity, we have developed simple, rapid assays for quantitating the…”
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Increased phospholipase D activity in multidrug resistant breast cancer cells by Welsh, C J, Yeh, G C, Phang, J M

“…An adriamycin-resistant MCF-7 cell line (300-fold increased resistance vs. wild type MCF-7) showed an increased phorbol ester-stimulated phospholipase D…”
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Evidence for a protein kinase C-directed mechanism in the phorbol diester-induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine by Cabot, Myles C., Welsh, Clement J., Zhang, Zu-chuan, Cao, Hui-ting

“…In this study we provide evidence for the involvement of protein kinase C (PKC) in phorbol diester-induced phosphatidylcholine (PC) hydrolysis by the…”
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Vasopressin stimulates phospholipase D activity against phosphatidylcholine in vascular smooth muscle cells by Welsh, Clement J., Schmeichel, Karen, Cao, Hui‐ting, Chabbott, Holly

“…It is now clear that various hormones and agonists can stimulate the production of lipid mediators from nonphosphoinositide phospholipids. We have investigated…”
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Accumulation of fatty alcohol in MCF-7 breast cancer cells by Welsh, C J, Robinson, M, Warne, T R, Pierce, J H, Yeh, G C, Phang, J M

“…The MCF-7 cell line (human breast epithelial cells) accumulates fatty alcohols. The fatty alcohols were identified as C16:0, C18:0, and C18:1 alcohols by…”
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sn-1,2-diacylglycerols and phorbol diesters: uptake, metabolism, and subsequent assimilation of the diacylglycerol metabolites into complex lipids of cultured cells by Welsh, C J, Cabot, M C

“…The cell-permeable diacylglycerol mediators have been shown to mimic partially the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on cultured cells. In…”
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Vasopressin is the only component of serum-free medium that stimulates phosphatidylcholine hydrolysis and accumulation of diacylglycerol in cultured REF52 cells by Welsh, C J, Cao, H T, Chabbott, H, Cabot, M C

“…Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing…”
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Book Review by Welsh, Clement J.

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Methods in Inositide Research by Clement J. Welsh

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Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond by Cabot, M C, Welsh, C J, Zhang, Z C, Cao, H T, Chabbott, H, Lebowitz, M

“…REF52, a rat embryo cell line, and several transformed derivatives were used to examine the lipid-related events associated with agonist treatment (phorbol…”
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Novel, species-typical esters from preputial glands of sympatric voles, Microtus montanus and M. pennsylvanicus by WELSH, C. J, MOORE, R. E, BARTELT, R. J, JACKSON, L. L

“…Olfactory signals may facilitate species recognition between the sympatric voles, Microtus montanus and M. pennsylvanicus . In an effort to isolate and…”
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Novel, species-typical esters from preputial glands of sympatric voles,Microtus montanus andM. pennsylvanicus by Welsh, C J, Moore, R E, Bartelt, R J, Jackson, L L

“…Olfactory signals may facilitate species recognition between the sympatric voles,Microtus montanus andM. pennsylvanicus. In an effort to isolate and identify…”
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