Search Results - "Welsh, C. Jane"

Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies by Eldridge, Raena, Osorio, Daniel, Amstalden, Katia, Edwards, Caitlin, Young, Colin R., Cai, James J., Konganti, Kranti, Hillhouse, Andrew, Threadgill, David W., Welsh, C. Jane, Brinkmeyer-Langford, Candice

“…Antecedent viral infection may contribute to increased susceptibility to several neurological diseases, such as multiple sclerosis and Parkinson’s disease…”
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Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection by Lawley, Koedi S, Rech, Raquel R, Elenwa, Faith, Han, Gang, Perez Gomez, Aracely A, Amstalden, Katia, Welsh, C Jane, Young, Colin R, Threadgill, David W, Brinkmeyer-Langford, Candice L

“…Host genetic background is a significant driver of the variability in neurological responses to viral infection. Here, we leverage the genetically diverse…”
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Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions by Brinkmeyer-Langford, Candice, Amstalden, Katia, Konganti, Kranti, Hillhouse, Andrew, Lawley, Koedi, Perez-Gomez, Aracely, Young, Colin R, Welsh, C Jane, Threadgill, David W

“…Virus-induced neurological sequelae resulting from infection by Theiler's murine encephalomyelitis virus (TMEV) are used for studying human conditions ranging…”
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Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection by Karmakar, Moumita, Pérez Gómez, Aracely A, Carroll, Raymond J, Lawley, Koedi S, Amstalden, Katia A Z, Welsh, C Jane, Threadgill, David W, Brinkmeyer-Langford, Candice

“…Neurological dysfunction following viral infection varies among individuals, largely due to differences in their genetic backgrounds. Gait patterns, which can…”
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Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background by Lawley, Koedi S, Rech, Raquel R, Perez Gomez, Aracely A, Hopkins, Laura, Han, Gang, Amstalden, Katia, Welsh, C Jane, Young, Colin R, Jones-Hall, Yava, Threadgill, David W, Brinkmeyer-Langford, Candice L

“…A wide range of viruses cause neurological manifestations in their hosts. Infection by neurotropic viruses as well as the resulting immune response can…”
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C57BL/6J mice exposed to perfluorooctanoic acid demonstrate altered immune responses and increased seizures after Theiler's murine encephalomyelitis virus infection by Pérez Gómez, Aracely A, Wang, Meichen, Kochan, Kelli, Amstalden, Katia, Young, Colin R, Welsh, C Jane, Phillips, Timothy D, Brinkmeyer-Langford, Candice L

“…Neurological diseases can stem from environmental influences such as antecedent viral infections or exposure to potential toxicants, some of which can trigger…”
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Serum Cytokines Predict Neurological Damage in Genetically Diverse Mouse Models by Pérez Gómez, Aracely A, Karmakar, Moumita, Carroll, Raymond J, Lawley, Koedi S, Amstalden, Katia, Young, Colin R, Threadgill, David W, Welsh, C Jane, Brinkmeyer-Langford, Candice

“…Viral infections contribute to neurological and immunological dysfunction driven by complex genetic networks. Theiler's murine encephalomyelitis virus (TMEV)…”
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Genetic and immunological contributors to virus-induced paralysis by Perez Gomez, Aracely A., Karmakar, Moumita, Carroll, Raymond J., Lawley, Koedi S., Amstalden, Katia, Young, Colin R., Threadgill, David W., Welsh, C. Jane, Brinkmeyer-Langford, Candice

“…Infection by a single virus can evoke diverse immune responses, resulting in different neurological outcomes, depending on the host's genetic background. To…”
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A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array by Jeong, Sehoon, Kim, Sunja, Buonocore, John, Park, Jaewon, Welsh, C. Jane, Li, Jianrong, Han, Arum

“…Objective: The blood-brain barrier (BBB) poses a unique challenge to the development of therapeutics against neurological disorders due to its impermeabi-lity…”
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Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection by Young, Erin E, Vichaya, Elisabeth G, Reusser, Nicole M, Cook, Jennifer L, Steelman, Andrew J, Welsh, C. Jane R, Meagher, Mary W

“…Abstract Prior exposure to social disruption (SDR) stress exacerbates Theiler's murine encephalomyelitis virus (TMEV) infection, a model of multiple sclerosis…”
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Restraint stress modulates virus specific adaptive immunity during acute Theiler’s virus infection by Steelman, Andrew J, Dean, Dana D, Young, Colin R, Smith, Roger, Prentice, Thomas W, Meagher, Mary W, Welsh, C. Jane R

“…Abstract Multiple sclerosis (MS) is a devastating CNS disease of unknown origin. Multiple factors including genetic background, infection, and psychological…”
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Galectin-9 Protein Is Up-regulated in Astrocytes by Tumor Necrosis Factor and Promotes Encephalitogenic T-cell Apoptosis by Steelman, Andrew J., Smith, Roger, Welsh, C. Jane, Li, Jianrong

“…Demyelination and axonal damage in multiple sclerosis (MS) are thought to be a consequence of inflammatory processes that are perpetuated by activated glia and…”
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Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler’s virus infection by Meagher, Mary W, Johnson, Robin R, Young, Erin E, Vichaya, Elisabeth G, Lunt, Shannon, Hardin, Elizabeth A, Connor, Marilyn A, Welsh, C. Jane R

“…Abstract Prior exposure to social disruption stress (SDR) exacerbates both the acute and chronic phase of Theiler’s murine encephalomyelitis virus infection…”
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Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity by Young, Erin E, Sieve, Amy N, Vichaya, Elisabeth G, Carcoba, Luis M, Young, Colin R, Ambrus, Andrew, Storts, Ralph, Welsh, C. Jane R, Meagher, Mary W

“…Abstract Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that…”
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Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection by Young, Erin E, Prentice, Thomas W, Satterlee, Danielle, McCullough, Heath, Sieve, Amy N, Johnson, Robin R, Welsh, Thomas H, Welsh, C. Jane R, Meagher, Mary W

“…Abstract Previous research has shown that chronic restraint stress exacerbates Theiler's virus infection, a murine model for CNS inflammation and multiple…”
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Host genetic background influences diverse neurological responses to viral infection in mice by Brinkmeyer-Langford, Candice L., Rech, Raquel, Amstalden, Katia, Kochan, Kelli J., Hillhouse, Andrew E., Young, Colin, Welsh, C. Jane, Threadgill, David W.

“…Infection by Theiler’s murine encephalomyelitis virus (TMEV) is a model for neurological outcomes caused by virus infection because it leads to diverse…”
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Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation by Van Sandt, Rae L, Welsh, C Jane, Jeffery, Nick D, Young, Colin R, McCreedy, Dylan A, Wright, Gus A, Boudreau, C Elizabeth, Levine, Gwendolyn J, Levine, Jonathan M

“…To investigate the time course of circulating neutrophil priming and activity in dogs with spinal cord injury secondary to intervertebral disk herniation that…”
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Differential abilities of central nervous system resident endothelial cells and astrocytes to serve as inducible antigen-presenting cells by Girvin, Ann M., Gordon, Kenneth B., Welsh, C. Jane, Clipstone, Neil A., Miller, Stephen D.

“…Microglial cells and astrocytes are capable of processing and presenting antigens for efficient activation of T cells. However, the antigen-presenting function…”
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Restraint stress facilitates systemic dissemination of Theiler's virus and alters its pathogenecity by Mi, Wentao, Young, Colin R., Storts, Ralph W., Steelman, Andrew J., Meagher, Mary W., Welsh, C. Jane R.

“…Theiler's murine encephalomyelitis virus (TMEV), a Picornavirus used as a viral model for multiple sclerosis (MS), causes an acute encephalomyelitis and…”
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Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury by Taylor, Amanda R, Welsh, C Jane, Young, Colin, Spoor, Erich, Kerwin, Sharon C, Griffin, John F, Levine, Gwendolyn J, Cohen, Noah D, Levine, Jonathan M

“…Canine intervertebral disk herniation (IVDH) is a common, naturally occurring form of spinal cord injury (SCI) that is increasingly being used in pre-clinical…”
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