Search Results - "Welsby, Philip J"

The Effect of Cryoprotectants and Storage Conditions on the Transfection Efficiency, Stability, and Safety of Lipid‐Based Nanoparticles for mRNA and DNA Delivery by Kafetzis, Konstantinos N., Papalamprou, Natalia, McNulty, Elisha, Thong, Kai X., Sato, Yusuke, Mironov, Aleksandr, Purohit, Atul, Welsby, Philip J., Harashima, Hideyoshi, Yu‐Wai‐Man, Cynthia, Tagalakis, Aristides D.

“…Lipid‐based nanoparticles have recently shown great promise, establishing themselves as the gold standard in delivering novel RNA therapeutics. However,…”
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Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus by Welsby, Philip J., Rowan, Michael J., Anwyl, Roger

“…We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long‐term potentiation (LTP) in the rat dentate gyrus in vitro…”
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Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma by Khan, Zahra R., Welsby, Philip J., Stasik, Izabela, Hayes, Joseph M.

“…Kinases have proven valuable targets in successful cancer drug discovery projects, but not yet for malignant brain tumors where type-II inhibition of…”
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Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its’ potential against glioblastoma in cellular models by Mathomes, Rachel T., Koulas, Symeon M., Tsialtas, Ioannis, Stravodimos, George, Welsby, Philip J., Psarra, Anna-Maria G., Stasik, Izabela, Leonidas, Demetres D., Hayes, Joseph M.

“…Glycogen phosphorylase (GP) is the rate-determining enzyme in the glycogenolysis pathway. Glioblastoma (GBM) is amongst the most aggressive cancers of the…”
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Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists by Welsby, Philip J, Kellett, Elaine, Wilkinson, Graeme, Milligan, Graeme

“…Fusion proteins between the human 5-hydroxytryptamine (5-HT)(1A) receptor and either wild type or certain pertussis toxin-resistant forms of G(o1)alpha and…”
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Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP by Welsby, Philip J., Rowan, Michael J., Anwyl, Roger

“…Nicotine has been postulated to be a possible neuroprotective agent in Alzheimer's Disease (AD). In the present studies, the effect of beta-amyloid (Aβ) was…”
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A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca2+/Calmodulin-Dependent Kinase II by Welsby, Philip J, Wang, Hongge, Wolfe, Joshua T, Colbran, Roger J, Johnson, Michael L, Barrett, Paula Q

“…Low-voltage-activated (LVA) Ca2+ channels are widely distributed throughout the CNS and are important determinants of neuronal excitability, initiating…”
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Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II by Yao, Junlan, Davies, Lucinda A, Howard, Jason D, Adney, Scott K, Welsby, Philip J, Howell, Nancy, Carey, Robert M, Colbran, Roger J, Barrett, Paula Q

“…Ang II receptor activation increases cytosolic Ca2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic…”
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Regulation of the avidity of ternary complexes containing the human 5‐HT1A receptor by mutation of a receptor contact site on the interacting G protein α subunit by Welsby, Philip J, Carr, I Craig, Wilkinson, Graeme, Milligan, Graeme

“…Fusion proteins were constructed between the human 5‐HT1A receptor and pertussis toxin‐resistant forms of both Gi1α and Go1α mutated at residue351 from…”
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P51PREPARATION OF ASIATIC ACID LOADED NANOPARTICLES FOR DELIVERY ACROSS THE BLOOD BRAIN BARRIER AND ITS EFFECTS ON GLIOBLASTOMA CELLS IN VITRO by Thakor, Flourina, Welsby, Philip J., Wan, Ka-Wai, Welsby, Gail

“…INTRODUCTION: Drug delivery across tight junctions of the blood brain barrier poses a significant challenge to glioma treatment. Biodegradable nanoparticles…”
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P51 PREPARATION OF ASIATIC ACID LOADED NANOPARTICLES FOR DELIVERY ACROSS THE BLOOD BRAIN BARRIER AND ITS EFFECTS ON GLIOBLASTOMA CELLS IN VITRO by Thakor, Flourina, Welsby, Philip J, Wan, Ka-Wai, Welsby, Gail

“…INTRODUCTION: Drug delivery across tight junctions of the blood brain barrier poses a significant challenge to glioma treatment. Biodegradable nanoparticles…”
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Regulation of the avidity of ternary complexes containing the human 5‐HT 1A receptor by mutation of a receptor contact site on the interacting G protein α subunit by Welsby, Philip J, Carr, I Craig, Wilkinson, Graeme, Milligan, Graeme

“…Fusion proteins were constructed between the human 5‐HT 1A receptor and pertussis toxin‐resistant forms of both G i1 α and G o1 α mutated at residue 351 from…”
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Molecular basis for the modulation of native T-type Ca super(2+) channels in vivo by Ca super(2+) /calmodulin-dependent protein kinase II by Yao, Junlan, Davies, Lucinda A, Howard, Jason D, Adney, Scott K, Welsby, Philip J, Howell, Nancy, Carey, Robert M, Colbran, Roger J, Barrett, Paula Q

“…Ang II receptor activation increases cytosolic Ca super(2+) levels to enhance the synthesis and secretion of aldosterone, a recently identified early…”
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Molecular basis for the modulation of native T-type [Ca.sup.2+] channels in vivo by [Ca.sup.2+]/calmodulin-dependent protein kinase II by Yao, Junlan, Davies, Lucinda A, Howard, Jason D, Adney, Scott K, Welsby, Philip J, Howell, Nancy, Carey, Robert M, Colbran, Roger J, Barrett, Paula Q

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Regulation of the avidity of ternary complexes containing the human 5-HT(1A) receptor by mutation of a receptor contact site on the interacting G protein alpha subunit by Welsby, Philip J, Carr, I Craig, Wilkinson, Graeme, Milligan, Graeme

“…1 Fusion proteins were constructed between the human 5-HT(1A) receptor and pertussis toxin-resistant forms of both G(i1)alpha and G(o1)alpha mutated at…”
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Regulation of the avidity of ternary complexes containing the human 5-HT1A receptor by mutation of a receptor contact site on the interacting G protein [alpha] subunit by Welsby, Philip J, Carr, I Craig, Wilkinson, Graeme, Milligan, Graeme

“…1 Fusion proteins were constructed between the human 5-HT(1A) receptor and pertussis toxin-resistant forms of both G(i1)alpha and G(o1)alpha mutated at…”
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A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca 2+ /Calmodulin-Dependent Kinase II by Welsby, Philip J., Wang, Hongge, Wolfe, Joshua T., Colbran, Roger J., Johnson, Michael L., Barrett, Paula Q.

“…Low-voltage-activated (LVA) Ca 2+ channels are widely distributed throughout the CNS and are important determinants of neuronal excitability, initiating…”
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Pharmacological characterisation of the human 5-HT1A receptor and its inhibitory G protein fusions by Welsby, Philip J

“…Fusion proteins between the human 5-HTIA receptor and wild type and pertussis toxin resistant forms of the Gi1α and Gi1α proteins were constructed and stably…”
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