Search Results - "Wells, Timothy NC"

Natural products as starting points for future anti-malarial therapies: going back to our roots? by Wells, Timothy N C

“…The discovery and development of new anti-malarials are at a crossroads. Fixed dose artemisinin combination therapy is now being used to treat a hundred…”
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The global pipeline of new medicines for the control and elimination of malaria by Anthony, Melinda P, Burrows, Jeremy N, Duparc, Stephan, Moehrle, Joerg J, Wells, Timothy N C

“…Over the past decade, there has been a transformation in the portfolio of medicines to combat malaria. New fixed-dose artemisinin combination therapy is…”
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A framework for assessing the risk of resistance for anti-malarials in development by Ding, Xavier C, Ubben, David, Wells, Timothy N C

“…Resistance is a constant challenge for anti-infective drug development. Since they kill sensitive organisms, anti-infective agents are bound to exert an…”
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New drugs for the control and elimination of malaria: a snapshot of the pipeline by Wells, Timothy NC

“…Doc number: O31…”
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A framework for assessing the risk of resistance for antimalarials in development by Ding, Xavier C, Ubben, David, Wells, Timothy NC

“…Doc number: P23…”
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New medicines to improve control and contribute to the eradication of malaria by Wells, Timothy NC

“…Despite being one of the most prevalent tropical diseases, for many years malaria was not a commercial priority for the pharmaceutical industry. However, in…”
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Malaria medicines: a glass half full? by Wells, Timothy N. C., van Huijsduijnen, Rob Hooft, Van Voorhis, Wesley C.

“…Key Points Antimalarial drug discovery has substantially contributed to the gains achieved against malaria over the past two decades. However, this progress…”
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The antimalarial pipeline by Hooft van Huijsduijnen, Rob, Wells, Timothy NC

“…•The antimalarial pipeline has been enriched with new molecules and targets.•The antimalarial target compound and product profiles have been redefined.•In…”
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Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria? by Hemingway, Janet, Shretta, Rima, Wells, Timothy N C, Bell, David, Djimdé, Abdoulaye A, Achee, Nicole, Qi, Gao

“…Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development…”
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New medicines to improve control and contribute to the eradication of malaria by Wells, Timothy N. C, Alonso, Pedro L, Gutteridge, Winston E

“…Key Points Currently available medicines against Plasmodium falciparum are largely fixed-dose artemisinin-based combination therapies; the combination serves…”
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Designing the next generation of medicines for malaria control and eradication by Burrows, Jeremy N, van Huijsduijnen, Rob Hooft, Möhrle, Jörg J, Oeuvray, Claude, Wells, Timothy N C

“…In the fight against malaria new medicines are an essential weapon. For the parts of the world where the current gold standard artemisinin combination…”
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Antimalarial drug discovery - the path towards eradication by Burrows, Jeremy N, Burlot, Emilie, Campo, Brice, Cherbuin, Stephanie, Jeanneret, Sarah, Leroy, Didier, Spangenberg, Thomas, Waterson, David, Wells, Timothy Nc, Willis, Paul

“…Malaria is a disease that still affects a significant proportion of the global human population. Whilst advances have been made in lowering the numbers of…”
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Ferroquine: welcome to the next generation of antimalarials by Wells, Timothy NC, van Huijsduijnen, Rob Hooft

“…During the past decade, tremendous progress has been made in the fight against malaria, and the number of cases and deaths from malaria has decreased by half…”
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Open data in drug discovery and development: lessons from malaria by Wells, Timothy N. C., Willis, Paul, Burrows, Jeremy N., van Huijsduijnen, Rob Hooft

“…There is a growing consensus that drug discovery thrives in an open environment. Here, we describe how the malaria community has embraced four levels of open…”
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Managing intellectual property to develop medicines for the world's poorest by Fonteilles-Drabek, Sylvie, Reddy, David, Wells, Timothy N. C.

“…It has been argued that patents impede the development and access of medicines for tropical diseases such as malaria. However, we believe that intellectual…”
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Is the Tide Turning for New Malaria Medicines? by Wells, Timothy N. C.

“…A return to traditional screening methods has rapidly produced a candidate malaria drug. Every so often, the tide turns in a field of science. In malaria…”
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Orally active antischistosomal early leads identified from the open access malaria box by Ingram-Sieber, Katrin, Cowan, Noemi, Panic, Gordana, Vargas, Mireille, Mansour, Nuha R, Bickle, Quentin D, Wells, Timothy N C, Spangenberg, Thomas, Keiser, Jennifer

“…Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of…”
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A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines by Delves, Michael J., Ramakrishnan, Chandra, Blagborough, Andrew M., Leroy, Didier, Wells, Timothy N.C., Sinden, Robert E.

“…[Display omitted] ► A novel Plasmodium transmission-stage screening assay is reported. ► The assay used in this study is high throughput, easy to perform and…”
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Targeting the hypnozoite reservoir of Plasmodium vivax : the hidden obstacle to malaria elimination by Wells, Timothy N.C, Burrows, Jeremy N, Baird, J. Kevin

“…Plasmodium vivax is the major species of malaria parasite outside Africa. It is especially problematic in that the infection can relapse in the absence of…”
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A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments: e0003987 by Huston, Christopher D, Spangenberg, Thomas, Burrows, Jeremy, Willis, Paul, Wells, Timothy NC, Voorhis, Wesley van

“…Numerous smaller studies had also demonstrated the importance of cryptosporidiosis in young children and its association with malnutrition (reviewed in [5])…”
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