Search Results - "Wells, Timothy N.C"

The state of the art in anti-malarial drug discovery and development by Burrows, Jeremy N, Chibale, Kelly, Wells, Timothy N C

“…Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet, unfortunately, apart from artemisinin combination therapies there…”
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Malaria medicines: a glass half full? by Wells, Timothy N. C., van Huijsduijnen, Rob Hooft, Van Voorhis, Wesley C.

“…Key Points Antimalarial drug discovery has substantially contributed to the gains achieved against malaria over the past two decades. However, this progress…”
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Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials by Duffey, Maëlle, Blasco, Benjamin, Burrows, Jeremy N., Wells, Timothy N.C., Fidock, David A., Leroy, Didier

“…Strategies to counteract or prevent emerging drug resistance are crucial for the design of next-generation antimalarials. In the past, resistant parasites were…”
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New medicines to improve control and contribute to the eradication of malaria by Wells, Timothy N. C, Alonso, Pedro L, Gutteridge, Winston E

“…Key Points Currently available medicines against Plasmodium falciparum are largely fixed-dose artemisinin-based combination therapies; the combination serves…”
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Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro by Jonsdottir, Hulda R., Siegrist, Denise, Julien, Thomas, Padey, Blandine, Bouveret, Mendy, Terrier, Olivier, Pizzorno, Andres, Huang, Song, Samby, Kirandeep, Wells, Timothy N.C., Boda, Bernadett, Rosa-Calatrava, Manuel, Engler, Olivier B., Constant, Samuel

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic with unprecedented economic and societal impact. Currently,…”
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Definition, function and pathophysiological significance of chemokine receptors by Wells, Timothy N.C, Power, Christine A, Proudfoot, Amanda E.I

“…Chemokines and their receptors are at the core of many processes in biology, from routine immunosurveillance and the inflammatory process, through to the…”
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Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis by Rufener, Reto, Dick, Luca, D'Ascoli, Laura, Ritler, Dominic, Hizem, Amani, Wells, Timothy N.C., Hemphill, Andrew, Lundström-Stadelmann, Britta

“…The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the lethal disease alveolar echinococcosis. Current chemotherapeutic treatment…”
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Orally active antischistosomal early leads identified from the open access malaria box by Ingram-Sieber, Katrin, Cowan, Noemi, Panic, Gordana, Vargas, Mireille, Mansour, Nuha R, Bickle, Quentin D, Wells, Timothy N C, Spangenberg, Thomas, Keiser, Jennifer

“…Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of…”
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A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments by Huston, Christopher D, Spangenberg, Thomas, Burrows, Jeremy, Willis, Paul, Wells, Timothy N C, van Voorhis, Wesley

“…  Numerous smaller studies had also demonstrated the importance of cryptosporidiosis in young children and its association with malnutrition (reviewed in [5])…”
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Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm by Preston, Sarah, Jiao, Yaqing, Jabbar, Abdul, McGee, Sean L., Laleu, Benoît, Willis, Paul, Wells, Timothy N.C., Gasser, Robin B.

“…There is a substantial need to develop new medicines against parasitic diseases via public-private partnerships. Based on high throughput phenotypic screens of…”
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Targeting the hypnozoite reservoir of Plasmodium vivax : the hidden obstacle to malaria elimination by Wells, Timothy N.C, Burrows, Jeremy N, Baird, J. Kevin

“…Plasmodium vivax is the major species of malaria parasite outside Africa. It is especially problematic in that the infection can relapse in the absence of…”
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Molecular Cloning and Characterization of a Highly Selective Chemokine-binding Protein from the Tick Rhipicephalus sanguineus by Frauenschuh, Achim, Power, Christine A., Déruaz, Maud, Ferreira, Beatriz R., Silva, João S., Teixeira, Mauro M., Dias, João M., Martin, Thierry, Wells, Timothy N.C., Proudfoot, Amanda E.I.

“…Ticks are blood-feeding parasites that secrete a number of immuno-modulatory factors to evade the host immune response. Saliva isolated from different species…”
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The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity by Proudfoot, Amanda E.I., Fritchley, Sarah, Borlat, Frédéric, Shaw, Jeffrey P., Vilbois, Francis, Zwahlen, Catherine, Trkola, Alexandra, Marchant, David, Clapham, Paul R., Wells, Timothy N.C.

“…The chemokine RANTES (regulated on activation normal T cell expressed and secreted; CCL5) binds selectively to glycosaminoglycans (GAGs) such as heparin,…”
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A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock by Chvatchko, Y, Hoogewerf, A J, Meyer, A, Alouani, S, Juillard, P, Buser, R, Conquet, F, Proudfoot, A E, Wells, T N, Power, C A

“…CC chemokine receptor (CCR)4, a high affinity receptor for the CC chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine…”
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The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness by Gonzalo, J A, Lloyd, C M, Wen, D, Albar, J P, Wells, T N, Proudfoot, A, Martinez-A, C, Dorf, M, Bjerke, T, Coyle, A J, Gutierrez-Ramos, J C

“…The complex pathophysiology of lung allergic inflammation and bronchial hyperresponsiveness (BHR) that characterize asthma is achieved by the regulated…”
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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity by Mack, M, Luckow, B, Nelson, P J, Cihak, J, Simmons, G, Clapham, P R, Signoret, N, Marsh, M, Stangassinger, M, Borlat, F, Wells, T N, Schlöndorff, D, Proudfoot, A E

“…CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal…”
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Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro by Kadi, Linda, Selvaraju, Ram, de Lys, Patricia, Proudfoot, Amanda E.I., Wells, Timothy N.C., Boschert, Ursula

“…Chemokines have recently been postulated to have important functions in the central nervous system (CNS) in addition to their principal role of directional…”
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Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist by Simmons, Graham, Clapham, Paul R., Picard, Laurent, Offord, Robin E., Rosenkilde, Mette M., Schwartz, Thue W., Buser, Raphaële, Timothy N. C. Wells, Amanda E. I. Proudfoot

“…The chemokine receptors CXCR4 and CCR5 have recently been shown to act as coreceptors, in concert with CD4, for human immunodeficiency virus-type 1 (HIV-1)…”
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RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis by Lloyd, C M, Minto, A W, Dorf, M E, Proudfoot, A, Wells, T N, Salant, D J, Gutierrez-Ramos, J C

“…The involvement of chemokines in inflammation is well established, but their functional role in disease progression, and particularly in the development of…”
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CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4 by Endres, Michael J, Clapham, Paul R, Marsh, Mark, Ahuja, Ména, Turner, Julie Davis, McKnight, Aine, Thomas, Jill F, Stoebenau-Haggarty, Beth, Choe, Sunny, Vance, Patricia J, Wells, Timothy N.C, Power, Christine A, Sutterwala, Shaheen S, Doms, Robert W, Landau, Nathaniel R, Hoxie, James A

“…Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the…”
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