Search Results - "Wells, S"

Cross-tissue immune cell analysis reveals tissue-specific features in humans by Domínguez Conde, C, Xu, C, Jarvis, L B, Rainbow, D B, Wells, S B, Gomes, T, Howlett, S K, Suchanek, O, Polanski, K, King, H W, Mamanova, L, Huang, N, Szabo, P A, Richardson, L, Bolt, L, Fasouli, E S, Mahbubani, K T, Prete, M, Tuck, L, Richoz, N, Tuong, Z K, Campos, L, Mousa, H S, Needham, E J, Pritchard, S, Li, T, Elmentaite, R, Park, J, Rahmani, E, Chen, D, Menon, D K, Bayraktar, O A, James, L K, Meyer, K B, Yosef, N, Clatworthy, M R, Sims, P A, Farber, D L, Saeb-Parsy, K, Jones, J L, Teichmann, S A

“…Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16…”
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Learning from Longitudinal Data in Electronic Health Record and Genetic Data to Improve Cardiovascular Event Prediction by Zhao, Juan, Feng, QiPing, Wu, Patrick, Lupu, Roxana A., Wilke, Russell A., Wells, Quinn S., Denny, Joshua C., Wei, Wei-Qi

“…Current approaches to predicting a cardiovascular disease (CVD) event rely on conventional risk factors and cross-sectional data. In this study, we applied…”
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Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism by Weitz, Jeffrey I, Lensing, Anthonie W.A, Prins, Martin H, Bauersachs, Rupert, Beyer-Westendorf, Jan, Bounameaux, Henri, Brighton, Timothy A, Cohen, Alexander T, Davidson, Bruce L, Decousus, Hervé, Freitas, Maria C.S, Holberg, Gerlind, Kakkar, Ajay K, Haskell, Lloyd, van Bellen, Bonno, Pap, Akos F, Berkowitz, Scott D, Verhamme, Peter, Wells, Philip S, Prandoni, Paolo

“…In this study involving nearly 3400 patients with venous thromboembolism, both prophylactic and therapeutic doses of rivaroxaban were superior to aspirin in…”
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A Metabolic Basis for Endothelial-to-Mesenchymal Transition by Xiong, Jianhua, Kawagishi, Hiroyuki, Yan, Ye, Liu, Jie, Wells, Quinn S., Edmunds, Lia R., Fergusson, Maria M., Yu, Zu-Xi, Rovira, Ilsa I., Brittain, Evan L., Wolfgang, Michael J., Jurczak, Michael J., Fessel, Joshua P., Finkel, Toren

“…Endothelial-to-mesenchymal transition (EndoMT) is a cellular process often initiated by the transforming growth factor β (TGF-β) family of ligands. Although…”
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Warming and redistribution of nitrogen inputs drive an increase in terrestrial nitrous oxide emission factor by Harris, E., Yu, L., Wang, Y-P., Mohn, J., Henne, S., Bai, E., Barthel, M., Bauters, M., Boeckx, P., Dorich, C., Farrell, M., Krummel, P. B., Loh, Z. M., Reichstein, M., Six, J., Steinbacher, M., Wells, N. S., Bahn, M., Rayner, P.

“…Anthropogenic nitrogen inputs cause major negative environmental impacts, including emissions of the important greenhouse gas N 2 O. Despite their importance,…”
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Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia by McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Saberi, Saeed, Swayampakula, Mridula, Venkateswaran, Geetha, Nemirovsky, Oksana, Gillespie, Jordan A., Karasinska, Joanna M., Kalloger, Steve E., Supuran, Claudiu T., Schaeffer, David F., Bashashati, Ali, Shah, Sohrab P., Topham, James T., Yapp, Donald T., Li, Jinyang, Renouf, Daniel J., Stanger, Ben Z., Dedhar, Shoukat

“…Most pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo and radiation…”
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CrRLK1L receptor‐like kinases HERK1 and ANJEA are female determinants of pollen tube reception by Galindo‐Trigo, Sergio, Blanco‐Touriñán, Noel, DeFalco, Thomas A, Wells, Eloise S, Gray, Julie E, Zipfel, Cyril, Smith, Lisa M

“…Communication between the gametophytes is vital for angiosperm fertilisation. Multiple Cr RLK1L‐type receptor kinases prevent premature pollen tube burst,…”
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Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty by Anderson, David R, Dunbar, Michael, Murnaghan, John, Kahn, Susan R, Gross, Peter, Forsythe, Michael, Pelet, Stephane, Fisher, William, Belzile, Etienne, Dolan, Sean, Crowther, Mark, Bohm, Eric, MacDonald, Steven J, Gofton, Wade, Kim, Paul, Zukor, David, Pleasance, Susan, Andreou, Pantelis, Doucette, Steve, Theriault, Chris, Abianui, Abongnwen, Carrier, Marc, Kovacs, Michael J, Rodger, Marc A, Coyle, Doug, Wells, Philip S, Vendittoli, Pascal-Andre

“…In a large, randomized trial involving patients undergoing knee or hip arthroplasty, aspirin was found to be noninferior to rivaroxaban in clot prevention and…”
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Microvascular Disease, Peripheral Artery Disease, and Amputation by Beckman, Joshua A, Duncan, Meredith S, Damrauer, Scott M, Wells, Quinn S, Barnett, Joey V, Wasserman, David H, Bedimo, Roger J, Butt, Adeel A, Marconi, Vincent C, Sico, Jason J, Tindle, Hilary A, Bonaca, Marc P, Aday, Aaron W, Freiberg, Matthew S

“…BACKGROUND:The mechanism of adverse limb events associated with peripheral artery disease remains incompletely understood. We investigated whether…”
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Multi-species measurements of nitrogen isotopic composition reveal the spatial constraints and biological drivers of ammonium attenuation across a highly contaminated groundwater system by Wells, Naomi S., Hakoun, Vivien, Brouyère, Serge, Knöller, Kay

“…Groundwater under industrial sites is characterised by heterogeneous chemical mixtures, making it difficult to assess the fate and transport of individual…”
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Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer by Shinde, Aparna, Hardy, Shana D, Kim, Dongwook, Akhand, Saeed Salehin, Jolly, Mohit Kumar, Wang, Wen-Hung, Anderson, Joshua C, Khodadadi, Ryan B, Brown, Wells S, George, Jason T, Liu, Sheng, Wan, Jun, Levine, Herbert, Willey, Christopher D, Krusemark, Casey J, Geahlen, Robert L, Wendt, Michael K

“…The ability of breast cancer cells to transiently transition between epithelial and mesenchymal states contributes to their metastatic potential. Therefore,…”
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Marine mammals harbor unique microbiotas shaped by and yet distinct from the sea by Bik, Elisabeth M., Costello, Elizabeth K., Switzer, Alexandra D., Callahan, Benjamin J., Holmes, Susan P., Wells, Randall S., Carlin, Kevin P., Jensen, Eric D., Venn-Watson, Stephanie, Relman, David A.

“…Marine mammals play crucial ecological roles in the oceans, but little is known about their microbiotas. Here we study the bacterial communities in 337 samples…”
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Apixaban for the prevention of venous thromboembolism in high-risk ambulatory cancer patients receiving chemotherapy: Rational and design of the AVERT trial by Kimpton, Miriam, Wells, Philip S., Carrier, Marc

“…Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although…”
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Profiling of the plasma proteome across different stages of human heart failure by Egerstedt, Anna, Berntsson, John, Smith, Maya Landenhed, Gidlöf, Olof, Nilsson, Roland, Benson, Mark, Wells, Quinn S., Celik, Selvi, Lejonberg, Carl, Farrell, Laurie, Sinha, Sumita, Shen, Dongxiao, Lundgren, Jakob, Rådegran, Göran, Ngo, Debby, Engström, Gunnar, Yang, Qiong, Wang, Thomas J., Gerszten, Robert E., Smith, J. Gustav

“…Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic…”
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Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy by Rodger, Marc A, Kahn, Susan R, Wells, Philip S, Anderson, David A, Chagnon, Isabelle, Le Gal, Grégoire, Solymoss, Susan, Crowther, Mark, Perrier, Arnaud, White, Richard, Vickars, Linda, Ramsay, Tim, Betancourt, Marisol T, Kovacs, Michael J

“…Whether to continue oral anticoagulant therapy beyond 6 months after an "unprovoked" venous thromboembolism is controversial. We sought to determine clinical…”
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Work-related stress and well-being of direct care workers in intellectual disability services: a scoping review of the literature by Ryan, Cathal, Bergin, Michael, Wells, John S.G.

“…Understanding the nature of work-related stress and burnout among intellectual disability care staff is important to protect the well-being of these workers…”
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Understanding the population consequences of disturbance by Pirotta, Enrico, Booth, Cormac G., Costa, Daniel P., Fleishman, Erica, Kraus, Scott D., Lusseau, David, Moretti, David, New, Leslie F., Schick, Robert S., Schwarz, Lisa K., Simmons, Samantha E., Thomas, Len, Tyack, Peter L., Weise, Michael J., Wells, Randall S., Harwood, John

“…Managing the nonlethal effects of disturbance on wildlife populations has been a long‐term goal for decision makers, managers, and ecologists, and assessment…”
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Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer by Brown, Wells S, Tan, Li, Smith, Andrew, Gray, Nathanael S, Wendt, Michael K

“…Therapeutic targeting of late-stage breast cancer is limited by an inadequate understanding of how tumor cell signaling evolves during metastatic progression…”
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FGFR signaling maintains a drug persistent cell population following epithelial-mesenchymal transition by Brown, Wells S, Akhand, Saeed Salehin, Wendt, Michael K

“…An emerging characteristic of drug resistance in cancer is the induction of epithelial-mesenchymal transition (EMT). However, the mechanisms of EMT-mediated…”
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Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery by Aragam, Krishna G, Chaffin, Mark, Levinson, Rebecca T, McDermott, Gregory, Choi, Seung Hoan, Shoemaker, M Benjamin, Haas, Mary E, Weng, Lu-Chen, Lindsay, Mark E, Smith, J Gustav, Newton-Cheh, Christopher, Roden, Dan M, London, Barry, Wells, Quinn S, Ellinor, Patrick T, Kathiresan, Sekar, Lubitz, Steven A

“…BACKGROUND:Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic…”
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