Search Results - "Wells, P G"

Pregnancy registries in epilepsy : A consensus statement on health outcomes by MEADOR, K. J, PENNELL, P. B, CRAMER, J. A, HARDEN, C. L, GORDON, J. C, TOMSON, T, KAPLAN, P. W, HOLMES, G. L, FRENCH, J. A, HAUSER, W. A, WELLS, P. G

“…Most pregnant women with epilepsy require antiepileptic drug (AED) therapy. Present guidelines recommend optimizing treatment prior to conception, choosing the…”
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State of the marine environment reports––a need to evaluate their role in marine environmental protection and conservation by Wells, P.G

“…This paper discusses the rationale behind the preparation of state of the marine environment (SOME) reports, and the need to evaluate their role in marine…”
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Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity by Wells, Peter G, Parman, Toufan, Wiley, Michael J

“…The sedative drug thalidomide ([+]-alpha-phthalimidoglutarimide), once abandoned for causing birth defects in humans, has found new therapeutic license in…”
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Gulfwatch: Monitoring spatial and temporal patterns of trace metal and organic contaminants in the Gulf of Maine (1991-1997) with the blue mussel, Mytilus edulis L by CHASE, M. E, JONES, S. H, PEDERSON, J, TAYLOR, D, HENNIGAR, P, SOWLES, J, HARDING, G. C. H, FREEMAN, K, WELLS, P. G, KRAHFORST, C, COOMBS, K, CRAWFORD, R

“…Gulfwatch, established in 1991, is an international contaminant monitoring program in which the blue mussel, Mytilus edulis, is used as an indicator of the…”
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Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity by Winn, L M, Wells, P G

“…A murine embryo culture model was used to investigate phenytoin-initiated embryonic DNA oxidation and dysmorphogenesis and to determine the embryoprotective…”
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Oxoguanine glycosylase 1 (OGG1) protects cells from DNA double-strand break damage following methylmercury (MeHg) exposure by Ondovcik, Stephanie L, Tamblyn, Laura, McPherson, John Peter, Wells, Peter G

“…Methylmercury (MeHg) is a potent neurotoxin, teratogen, and probable carcinogen, but the underlying mechanisms of its actions remain unclear. Although MeHg…”
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Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis by Winn, Louise M., Wells, Peter G.

“…A mouse embryo culture model was used to determine whether embryonic prostaglandin H synthase (PHS)-catalyzed bioactivation and resultant oxidative damage to…”
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Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate by Arlen, R R, Wells, P G

“…Thalidomide is a teratogenic sedative-hypnotic drug that is structurally similar to phenytoin, which is thought to be bioactivated by prostaglandin H synthase…”
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In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in Gunn and RHA rats with a genetic deficiency in bilirubin uridine diphosphate-glucuronosyltransferase by Hu, Z, Wells, P G

“…Like many polycyclic aromatic hydrocarbons in the environment, >30% of benzo(a)pyrene (BP), an environmental carcinogen and teratogen, is eliminated by…”
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Biomonitoring the Health of Coastal Marine Ecosystems – The Roles and Challenges of Microscale Toxicity Tests by Wells, Peter G

“…Coastal marine ecosystems in many parts of the world are under unrelenting stress caused by urban development, hazardous or toxic substances, overfishing,…”
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The editorial ‘Missing and needed: Polar marine ecotoxicology’ by P.M. Chapman and M.J. Riddle by Wells, P.G.

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Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients: Toxicological and pathological implications by WALMSLEY, S. L, WINN, L. M, HARRISON, M. L, UETRECHT, J. P, WELLS, P. G

“…To determine, first, whether the plasma and lymphocytes of HIV-positive individuals and AIDS patients have alterations in the major thiols glutathione and…”
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Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene by KIM, P. M, WELLS, P. G

“…UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation and elimination of putative tobacco carcinogens such as benzo[a]pyrene (B[a]P) and…”
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In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase, and thyroid peroxidase by Kubow, S, Wells, P G

“…Certain toxic effects of phenytoin are thought to result from its cytochrome P-450-catalyzed bioactivation to a reactive arene oxide intermediate that binds…”
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Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts by VIENNEAU, D. S, DEBONI, U, WELLS, P. G

“…UDP-glucuronosyltransferases (UGTs) are cytoprotective and may also be genoprotective. Since over 10% of the population have hereditary deficiencies in UGTs,…”
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Potential Molecular Targets Mediating Chemical Teratogenesis: In Vitro Peroxidase-Catalyzed Phenytoin Metabolism and Oxidative Damage to Proteins and Lipids in Murine Maternal Hepatic Microsomes and Embryonic 9000g Supernatant by Liu, L., Wells, P.G.

“…Phenytoin and related proteratogens may be bioactivated by peroxidases to a reactive free radical intermediate that initiates teratogenesis. This study…”
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DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: Phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2′-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues by Liu, Ling, Wells, Peter G.

“…A considerable number of teratogens, including the anticonvulsant drug phenytoin and structurally related drugs and environmental chemicals, may be…”
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Key(s) to marine ecology and understanding pollution impacts – a tribute to Dr. Howard Sanders, Marine Benthic Biologist Extra-Ordinaire by Pearce, J.B, Wells, P.G

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Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) by Wong, M, Wells, P G

“…The teratogenicity of phenytoin may be mediated through a reactive electrophilic and/or free radical intermediate which, if not detoxified, may interact with…”
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Modulation of embryonic glutathione peroxidase activity and phenytoin teratogenicity by dietary deprivation of selenium in CD-1 mice by Ozolins, T R, Siksay, D L, Wells, P G

“…Selenium (Se)-dependent and -independent glutathione (GSH) peroxidases detoxify H2O2 and lipid hydroperoxides, which may mediate the teratogenicity of…”
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