Search Results - "Wells, Julia E."

Deregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancer by Wells, Julia E., Howlett, Meegan, Cole, Catherine H., Kees, Ursula R.

“…Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific…”
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New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment by Cheung, Laurence C., Tickner, Jennifer, Hughes, Anastasia M., Skut, Patrycja, Howlett, Meegan, Foley, Bree, Oommen, Joyce, Wells, Julia E., He, Bo, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Mullighan, Charles G., Kotecha, Rishi S., Kees, Ursula R.

“…The microenvironments of leukemia and cancer are critical for multiple stages of malignancies, and they are an attractive therapeutic target. While skeletal…”
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Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia by Yadav, Babasaheb D, Samuels, Amy L, Wells, Julia E, Sutton, Rosemary, Venn, Nicola C, Bendak, Katerina, Anderson, Denise, Marshall, Glenn M, Cole, Catherine H, Beesley, Alex H, Kees, Ursula R, Lock, Richard B

“…Relapse in pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem and is thought to be associated with clonal selection…”
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Abstract 3075: Anti-leukemic activity of BCL-2/BCL-XL dual inhibitor - AZD0466 in T-acute lymphoblastic leukemia preclinical models by Kannan, Sankaranarayanan, Ghotbaldini, Sanaz, Wells, Julia E., Zhang, Qi, Balachander, Srividya, Cidado, Justin, Konopleva, Marina

“…Upregulation of BCL-2 family proteins, such as BCL-2 and BCL-XL, leads to imbalanced ratio between pro-death and pro-survival proteins that favors leukemic…”
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Deregulated expression of connective tissue growth factor ( CTGF / CCN2) is linked to poor outcome in human cancer: CTGF and Cancer by Wells, Julia E., Howlett, Meegan, Cole, Catherine H., Kees, Ursula R.

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Abstract B46: Connective Tissue Growth Factor (CTGF/CCN2) is increased in pre-B acute lymphoblastic leukemia and confers a growth advantage within the bone marrow niche by Wells, Julia E., Howlett, Meegan, Halse, Heloise M., Ford, Jette, Heng, Jasmin, Samuels, Amy L., Cole, Catherine H., Kees, Ursula R.

“…Introduction: Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Despite major improvements in cure rates, a significant number…”
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