Search Results - "Wells, Christine A"

Ten simple rules for navigating the computational aspect of an interdisciplinary PhD by Islam, Sabrina, Wells, Christine A

“…The interdisciplinary nature of modern research brings new treasures to the adventurer—the internal rewards come in forms of mastering skills and overcoming…”
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Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias by Chaudhury, Shahzya, O’Connor, Caitríona, Cañete, Ana, Bittencourt-Silvestre, Joana, Sarrou, Evgenia, Prendergast, Áine, Choi, Jarny, Johnston, Pamela, Wells, Christine A., Gibson, Brenda, Keeshan, Karen

“…Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children…”
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Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages by Butcher, Suzanne K, O'Carroll, Christine E, Wells, Christine A, Carmody, Ruaidhrí J

“…Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. The physiological role…”
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IsoVis - a webserver for visualization and annotation of alternative RNA isoforms by Wan, Ching Yin, Davis, Jack, Chauhan, Manveer, Gleeson, Josie, Prawer, Yair D J, De Paoli-Iseppi, Ricardo, Wells, Christine A, Choi, Jarny, Clark, Michael B

“…Genes commonly express multiple RNA products (RNA isoforms), which differ in exonic content and can have different functions. Making sense of the plethora of…”
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease by Baillie, J Kenneth, Arner, Erik, Daub, Carsten, De Hoon, Michiel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Forrest, Alistair R R, Hayashizaki, Yoshihide, Faulkner, Geoffrey J, Wells, Christine A, Rehli, Michael, Pavli, Paul, Summers, Kim M, Hume, David A

“…The FANTOM5 consortium utilised cap analysis of gene expression (CAGE) to provide an unprecedented insight into transcriptional regulation in human cells and…”
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Transcriptional Profiling of Stem Cells: Moving from Descriptive to Predictive Paradigms by Wells, Christine A., Choi, Jarny

“…Transcriptional profiling is a powerful tool commonly used to benchmark stem cells and their differentiated progeny. As the wealth of stem cell data builds in…”
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Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells by Somma, Domenico, Kok, Fatma O, Kerrigan, David, Wells, Christine A, Carmody, Ruaidhrí J

“…Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what…”
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The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons by Ovchinnikov, Dmitry A., Korn, Othmar, Virshup, Isaac, Wells, Christine A., Wolvetang, Ernst J.

“…Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly attributed to an increased dosage of the amyloid precursor protein (APP) gene…”
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Stemformatics: visualize and download curated stem cell data by Choi, Jarny, Pacheco, Chris M, Mosbergen, Rowland, Korn, Othmar, Chen, Tyrone, Nagpal, Isha, Englart, Steve, Angel, Paul W, Wells, Christine A

“…Abstract Stemformatics is an established gene expression data portal containing over 420 public gene expression datasets derived from microarray, RNA…”
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Discovery of NRG1-VII: the myeloid-derived class of NRG1 by Berrocal-Rubio, Miguel A, Pawer, Yair David Joseph, Dinevska, Marija, De Paoli-Iseppi, Ricardo, Widodo, Samuel S, Gleeson, Josie, Rajab, Nadia, De Nardo, Will, Hallab, Jeannette, Li, Anran, Mantamadiotis, Theo, Clark, Michael B, Wells, Christine A

“…The growth factor Neuregulin-1 (NRG1) has pleiotropic roles in proliferation and differentiation of the stem cell niche in different tissues. It has been…”
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Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal by Lau, Kevin X., Mason, Elizabeth A., Kie, Joshua, De Souza, David P., Kloehn, Joachim, Tull, Dedreia, McConville, Malcolm J., Keniry, Andrew, Beck, Tamara, Blewitt, Marnie E., Ritchie, Matthew E., Naik, Shalin H., Zalcenstein, Daniela, Korn, Othmar, Su, Shian, Romero, Irene Gallego, Spruce, Catrina, Baker, Christopher L., McGarr, Tracy C., Wells, Christine A., Pera, Martin F.

“…Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast stem cells, which correspond to…”
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The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans by Wells, Christine A, Salvage-Jones, Judith A, Li, Xin, Hitchens, Kelly, Butcher, Suzanne, Murray, Rachael Z, Beckhouse, Anthony G, Lo, Yu-Lan-Sandra, Manzanero, Silvia, Cobbold, Christian, Schroder, Kate, Ma, Bo, Orr, Sally, Stewart, Lauren, Lebus, Daniel, Sobieszczuk, Peter, Hume, David A, Stow, Jennifer, Blanchard, Helen, Ashman, Robert B

“…The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the…”
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A simple, scalable approach to building a cross-platform transcriptome atlas by Angel, Paul W, Rajab, Nadia, Deng, Yidi, Pacheco, Chris M, Chen, Tyrone, Lê Cao, Kim-Anh, Choi, Jarny, Wells, Christine A

“…Gene expression atlases have transformed our understanding of the development, composition and function of human tissues. New technologies promise improved…”
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Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye by Lee, Ellen J, Brown, Brieanna R, Vance, Emily E, Snow, Paige E, Silver, Phyllis B, Heinrichs, David, Lin, Xin, Iwakura, Yoichiro, Wells, Christine A, Caspi, Rachel R, Rosenzweig, Holly L

“…Uveitis, which occurs in association with systemic immunological diseases, presents a considerable medical challenge because of incomplete understanding of its…”
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Australian researchers’ perceptions and experiences with stem cell registration by Hu, Mengqi, Santos, Dan, Lopes, Edilene, Nicol, Dianne, Kurtz, Andreas, Mah, Nancy, Muller, Sabine, Ankeny, Rachel A., Wells, Christine A.

“…•Researchers who perceive registration as a publication hurdle are unlikely to complete the registration process.•Incomplete registration promotes…”
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An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator by Lee, Dong-Sung, Shin, Jong-Yeon, Tonge, Peter D., Puri, Mira C., Lee, Seungbok, Park, Hansoo, Lee, Won-Chul, Hussein, Samer M. I., Bleazard, Thomas, Yun, Ji-Young, Kim, Jihye, Li, Mira, Cloonan, Nicole, Wood, David, Clancy, Jennifer L., Mosbergen, Rowland, Yi, Jae-Hyuk, Yang, Kap-Seok, Kim, Hyungtae, Rhee, Hwanseok, Wells, Christine A., Preiss, Thomas, Grimmond, Sean M., Rogers, Ian M., Nagy, Andras, Seo, Jeong-Sun

“…Reprogramming of somatic cells to induced pluripotent stem cells involves a dynamic rearrangement of the epigenetic landscape. To characterize this epigenomic…”
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Single-Cell Gene Expression Profiles Define Self-Renewing, Pluripotent, and Lineage Primed States of Human Pluripotent Stem Cells by Hough, Shelley R., Thornton, Matthew, Mason, Elizabeth, Mar, Jessica C., Wells, Christine A., Pera, Martin F.

“…Pluripotent stem cells display significant heterogeneity in gene expression, but whether this diversity is an inherent feature of the pluripotent state remains…”
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An atypical role for the myeloid receptor Mincle in central nervous system injury by Arumugam, Thiruma V, Manzanero, Silvia, Furtado, Milena, Biggins, Patrick J, Hsieh, Yu-Hsuan, Gelderblom, Mathias, MacDonald, Kelli PA, Salimova, Ekaterina, Li, Yu-I, Korn, Othmar, Dewar, Deborah, Macrae, I Mhairi, Ashman, Robert B, Tang, Sung-Chun, Rosenthal, Nadia A, Ruitenberg, Marc J, Magnus, Tim, Wells, Christine A

“…The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well…”
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Human CD141 + Dendritic Cell and CD1c + Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo by Minoda, Yoshihito, Virshup, Isaac, Leal Rojas, Ingrid, Haigh, Oscar, Wong, Yide, Miles, John J, Wells, Christine A, Radford, Kristen J

“…Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34 hematopoietic stem cells. These "humanized" mice are useful…”
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Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses by Alikhan, Maliha A, Jones, Christina V, Williams, Timothy M, Beckhouse, Anthony G, Fletcher, Anne L, Kett, Michelle M, Sakkal, Samy, Samuel, Chrishan S, Ramsay, Robert G, Deane, James A, Wells, Christine A, Little, Melissa H, Hume, David A, Ricardo, Sharon D

“…Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of…”
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