Search Results - "Wellman, Andrew"

Defining Phenotypic Causes of Obstructive Sleep Apnea: Identification of Novel Therapeutic Targets by ECKERT, Danny J, WHITE, David P, JORDAN, Amy S, MALHOTRA, Atul, WELLMAN, Andrew

“…The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized. To define carefully the…”
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The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study by Azarbarzin, Ali, Sands, Scott A, Stone, Katie L, Taranto-Montemurro, Luigi, Messineo, Ludovico, Terrill, Philip I, Ancoli-Israel, Sonia, Ensrud, Kristine, Purcell, Shaun, White, David P, Redline, Susan, Wellman, Andrew

“…Abstract Aims Apnoea–hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity, poorly predicts the adverse outcomes of sleep apnoea,…”
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial by Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A, Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A, Eckert, Danny J, White, David P, Wellman, Andrew

“…There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and…”
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The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure by Azarbarzin, Ali, Sands, Scott A., Taranto-Montemurro, Luigi, Vena, Daniel, Sofer, Tamar, Kim, Sang-Wook, Stone, Katie L., White, David P., Wellman, Andrew, Redline, Susan

“…Heart failure (HF) is a leading cause of morbidity and mortality and although it is linked to sleep apnea, which physiological stressors most strongly…”
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Effects of the Combination of Atomoxetine and Oxybutynin on OSA Endotypic Traits by Taranto-Montemurro, Luigi, Messineo, Ludovico, Azarbarzin, Ali, Vena, Daniel, Hess, Lauren B., Calianese, Nicole A., White, David P., Wellman, Andrew, Sands, Scott A.

“…We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep…”
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Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis by Won, Christine H J, Reid, Michelle, Sofer, Tamar, Azarbarzin, Ali, Purcell, Shaun, White, David, Wellman, Andrew, Sands, Scott, Redline, Susan

“…Abstract Study Objectives The bases for sex disparities in obstructive sleep apnea (OSA), is poorly understood. We quantified the influences of event…”
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A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia by Kaur, Satvinder, Wang, Joshua L., Ferrari, Loris, Thankachan, Stephen, Kroeger, Daniel, Venner, Anne, Lazarus, Michael, Wellman, Andrew, Arrigoni, Elda, Fuller, Patrick M., Saper, Clifford B.

“…The precise neural circuitry that mediates arousal during sleep apnea is not known. We previously found that glutamatergic neurons in the external lateral…”
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Arousal Intensity is a Distinct Pathophysiological Trait in Obstructive Sleep Apnea by Amatoury, Jason, Azarbarzin, Ali, Younes, Magdy, Jordan, Amy S., Wellman, Andrew, Eckert, Danny J.

“…Abstract Study Objectives: Arousals from sleep vary in duration and intensity. Accordingly, the physiological consequences of different types of arousals may…”
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Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea by Sands, Scott A, Terrill, Philip I, Edwards, Bradley A, Taranto Montemurro, Luigi, Azarbarzin, Ali, Marques, Melania, de Melo, Camila M, Loring, Stephen H, Butler, James P, White, David P, Wellman, Andrew

“…Abstract Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient’s pathophysiological “traits.”…”
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Obstructive sleep apnea in older adults is a distinctly different physiological phenotype by Edwards, Bradley A, Wellman, Andrew, Sands, Scott A, Owens, Robert L, Eckert, Danny J, White, David P, Malhotra, Atul

“…Current evidence suggests that the pathological mechanisms underlying obstructive sleep apnea (OSA) are altered with age. However, previous studies examining…”
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Sleep apnea patients with epiglottic collapse elevate their larynx more with swallowing; videofluoroscopic swallowing study of 80 patients by Yang, Hyung Chae, Umugire, Alphonse, Song, Min-Keun, Man, Sung Chung, Kim, Hong Chan, Kim, Jisun, Vena, Daniel, Huyett, Phillip, Choi, Insung, Wellman, Andrew D.

“…Objective The epiglottis plays an integral role in the swallowing mechanism and is also implicated as an obstruction site in obstructive sleep apnea (OSA). The…”
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A method for measuring and modeling the physiological traits causing obstructive sleep apnea by WELLMAN, Andrew, ECKERT, Danny J, JORDAN, Amy S, EDWARDS, Bradley A, PASSAGLIA, Chris L, JACKSON, Andrew C, GAUTAM, Shiva, OWENS, Robert L, MALHOTRA, Atul, WHITE, David P

“…There is not a clinically available technique for measuring the physiological traits causing obstructive sleep apnea (OSA). Therefore, it is often difficult to…”
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Head rotation improves airway obstruction, especially in patients with less severe obstructive sleep apnea without oropharyngeal collapse by Tan, Shi Nee, Kim, Jong-Min, Kim, Jisun, Sung, Chung Man, Kim, Hong Chan, Lee, Jongho, Lim, Sang Chul, White, David P, Yang, Hyung Chae, Wellman, D Andrew

“…Head rotation is thought to have an effect on obstructive sleep apnea (OSA) severity. However, keeping the head rotated fully during sleep is difficult to…”
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Effect of oxygen in obstructive sleep apnea: Role of loop gain by Wellman, Andrew, Malhotra, Atul, Jordan, Amy S, Stevenson, Karen E, Gautam, Shiva, White, David P

“…Abstract We compared the effect of oxygen on the apnea–hypopnea index (AHI) in six obstructive sleep apnea patients with a relatively high loop gain (LG) and…”
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Breath-holding as a novel approach to risk stratification in COVID-19 by Messineo, Ludovico, Perger, Elisa, Corda, Luciano, Joosten, Simon A, Fanfulla, Francesco, Pedroni, Leonardo, Terrill, Philip I, Lombardi, Carolina, Wellman, Andrew, Hamilton, Garun S, Malhotra, Atul, Vailati, Guido, Parati, Gianfranco, Sands, Scott A

“…Despite considerable progress, it remains unclear why some patients admitted for COVID-19 develop adverse outcomes while others recover spontaneously. Clues…”
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The influence of aging on pharyngeal collapsibility during sleep by Eikermann, Matthias, Jordan, Amy S, Chamberlin, Nancy L, Gautam, Shiva, Wellman, Andrew, Lo, Yu-Lun, White, David P, Malhotra, Atul

“…Aging increases vulnerability to obstructive sleep apnea (OSA), but the underlying mechanisms remain unclear. Recent data in awake healthy volunteers show a…”
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Airway Dilator Muscle Activity and Lung Volume During Stable Breathing in Obstructive Sleep Apnea by JORDAN, Amy S, WHITE, David P, LO, Yu-Lun, WELLMAN, Andrew, ECKERT, Danny J, YIM-YEH, Susie, EIKERMANN, Matthias, SMITH, Scott A, STEVENSON, Karen E, MALHOTRA, Atul

“…Many patients with obstructive sleep apnea (OSA) have spontaneous periods of stable flow limited breathing during sleep without respiratory events or arousals…”
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Effect of Dupilumab on Sleep Apnea Severity in Patients With Chronic Rhinosinusitis by Kim, Sang-Wook, Sands, Scott A., Vena, Daniel, Hess, Lauren B., Calianese, Nicole A., Konefal, Robert James, Taranto-Montemurro, Luigi, Azarbarzin, Ali, Czeisler, Charles A., Laidlaw, Tanya M., Wellman, Andrew

“…Patients with chronic rhinosinusitis (CRS) report improved sleep quality after dupilumab, an anti IL4/13 therapy. Concurrent CRS and obstructive sleep apnea…”
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Ventilatory Control and Airway Anatomy in Obstructive Sleep Apnea by Wellman, Andrew, Jordan, Amy S, Malhotra, Atul, Fogel, Robert B, Katz, Eliot S, Schory, Karen, Edwards, Jill K, White, David P

“…Ventilatory instability may play an important role in the pathogenesis of obstructive sleep apnea. We hypothesized that the influence of ventilatory…”
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Comparison of Drug-Induced Sleep Endoscopy and Natural Sleep Endoscopy in the Assessment of Upper Airway Pathophysiology During Sleep: Protocol and Study Design by Van den Bossche, Karlien, Van de Perck, Eli, Wellman, Andrew, Kazemeini, Elahe, Willemen, Marc, Verbraecken, Johan, Vanderveken, Olivier M, Vena, Daniel, Op de Beeck, Sara

“…Obstructive sleep apnea (OSA) is increasingly recognized as a complex and heterogenous disorder. As a result, a "one-size-fits-all" management approach should…”
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