Search Results - "Welling, Cris M."

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation by Tanabe, Katsuya, Liu, Yang, Hasan, Syed D, Martinez, Sara C, Cras-Méneur, Corentin, Welling, Cris M, Bernal-Mizrachi, Ernesto, Tanizawa, Yukio, Rhodes, Christopher J, Zmuda, Erik, Hai, Tsonwin, Abumrad, Nada A, Permutt, M Alan

“…The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death…”
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Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance by Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Meneur, Corentin, Martinez, Sara C, Welling, Cris M, White, Morris F, Bernal-Mizrachi, Ernesto, Woodgett, James R, Permutt, M. Alan

“…Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and…”
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Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians by INOUE, H, FERRER, J, PROVINCE, M, BRYAN, J, PERMUTT, M. A, AGUILAR-BRYAN, L, WELLING, C. M, ELBEIN, S. C, HOFFMAN, M, MAYORGA, R, WARREN-PERRY, M, ZHANG, Y, MILLNS, H, TURNER, R

“…NIDDM is a common heterogeneous disorder, the genetic basis of which has yet to be determined. The sulfonylurea receptor (SUR) gene, now known to encode an…”
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Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance by Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Méneur, Corentin, Martinez, Sara C, Welling, Cris M, White, Morris F, Bernal-Mizrachi, Ernesto, Woodgett, James R, Permutt, M Alan

“…Despite treatment with agents that enhance beta-cell function and insulin action, reduction in beta-cell mass is relentless in patients with insulin resistance…”
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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia by Bernal-Mizrachi, E, Wen, W, Stahlhut, S, Welling, C M, Permutt, M A

“…The phosphoinositide 3-kinase-Akt/PKB pathway mediates the mitogenic effects various nutrients and growth factors in cultured cells. To study its effects in…”
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Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3[beta] Independent of JNK Activation by Tanabe, Katsuya, Liu, Yang, Hasan, Syed D, Martinez, Sara C, Cras-Méneur, Corentin, Welling, Cris M, Bernal-Mizrachi, Ernesto, Tanizawa, Yukio, Rhodes, Christopher J, Zmuda, Erik, Hai, Tsonwin, Abumrad, Nada A, Permutt, M. Alan

“…Background The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic…”
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Genetic Deficiency of Glycogen Synthase Kinase-3b Corrects Diabetes in Mouse Models of Insulin Resistance by Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Meneur, Corentin, Martinez, Sara C, Welling, Cris M, White, Morris F, Bernal-Mizrachi, Ernesto, Woodgett, James R, Permutt, MAlan, Vidal-Puig, Antonio J

“…Despite treatment with agents that enhance b-cell function and insulin action, reduction in b-cell mass is relentless in patients with insulin resistance and…”
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Genetic Deficiency of Glycogen Synthase Kinase-3[beta] Corrects Diabetes in Mouse Models of Insulin Resistance: e37 by Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Méneur, Corentin, Martinez, Sara C, Welling, Cris M, White, Morris F, Bernal-Mizrachi, Ernesto, Woodgett, James R, Permutt, M Alan

“…Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and…”
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Human Cholecystokinin Type A Receptor Gene: Cytogenetic Localization, Physical Mapping, and Identification of Two Missense Variants in Patients with Obesity and Non-Insulin-Dependent Diabetes Mellitus (NIDDM) by Inoue, Hiroshi, Iannotti, Christopher A., Welling, Cris M., Veile, Rosalie, Donis-Keller, Helen, Permutt, M.Alan

“…The human CCKAR gene was previously mapped to chromosome 4 using a panel of human/hamster somatic cell hybrids. We now report the cytogenetic and physical…”
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Human Liver Glucokinase Gene: Cloning and Sequence Determination of Two Alternatively Spliced cDNAs by Tanizawa, Yukio, Koranyi, Laszlo I., Welling, Cris M., Permutt, M. Alan

“…A human liver glucokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) cDNA was isolated from a liver cDNA library. This cDNA (hLGLK1) appeared to be full…”
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Human islet glucokinase gene : isolation and sequence analysis of full-length cDNA by KORANYI, L. I, TANIZAWA, Y, WELLING, C. M, RABIN, D. U, PERMUTT, A. A

“…Pancreatic islet glucokinase (ATP:D-hexose-6-phosphotransferase) cDNAs were isolated from a human islet cDNA library in lambda-gt11. One clone (hlGLK2), 2723…”
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