Search Results - "Wellhausen, Nils"

Identification and Development of Therapeutics for COVID-19 by Rando, Halie M, Wellhausen, Nils, Ghosh, Soumita, Lee, Alexandra J, Dattoli, Anna Ada, Hu, Fengling, Byrd, James Brian, Rafizadeh, Diane N, Lordan, Ronan, Qi, Yanjun, Sun, Yuchen, Brueffer, Christian, Field, Jeffrey M, Ben Guebila, Marouen, Jadavji, Nafisa M, Skelly, Ashwin N, Ramsundar, Bharath, Wang, Jinhui, Goel, Rishi Raj, Park, YoSon, Boca, Simina M, Gitter, Anthony, Greene, Casey S

“…After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021,…”
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Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma by O’Connell, Ryan P, Liaw, Kevin, Wellhausen, Nils, Chuckran, Christopher A, Bhojnagarwala, Pratik S, Bordoloi, Devivasha, Park, Daniel, Shupin, Nicholas, Kulp, Daniel, June, Carl H, Weiner, David

“…BackgroundAdvanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer for which long-term survival rates are abysmal, though immunotherapies…”
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Application of Traditional Vaccine Development Strategies to SARS-CoV-2 by Rando, Halie M, Lordan, Ronan, Lee, Alexandra J, Naik, Amruta, Wellhausen, Nils, Sell, Elizabeth, Kolla, Likhitha, Gitter, Anthony, Greene, Casey S

“…Over the past 150 years, vaccines have revolutionized the relationship between people and disease. During the COVID-19 pandemic, technologies such as mRNA…”
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The Coming of Age of Nucleic Acid Vaccines during COVID-19 by Rando, Halie M, Lordan, Ronan, Kolla, Likhitha, Sell, Elizabeth, Lee, Alexandra J, Wellhausen, Nils, Naik, Amruta, Kamil, Jeremy P, Gitter, Anthony, Greene, Casey S

“…In the 21st century, several emergent viruses have posed a global threat. Each pathogen has emphasized the value of rapid and scalable vaccine development…”
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CD45 threads the needle of cytokine cancer immunotherapy by Wellhausen, Nils, Gill, Saar

“…Immunocytokines are cytokine-based fusion proteins with therapeutic potential. New CD45-targeted immunocytokines can reprogram systemic anti-tumor immunity by…”
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Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure by Rando, Halie M., MacLean, Adam L., Lee, Alexandra J., Lordan, Ronan, Ray, Sandipan, Bansal, Vikas, Skelly, Ashwin N., Sell, Elizabeth, Dziak, John J., Shinholster, Lamonica, D’Agostino McGowan, Lucy, Ben Guebila, Marouen, Wellhausen, Nils, Knyazev, Sergey, Boca, Simina M., Capone, Stephen, Qi, Yanjun, Park, YoSon, Mai, David, Sun, Yuchen, Boerckel, Joel D., Brueffer, Christian, Byrd, James Brian, Kamil, Jeremy P., Wang, Jinhui, Velazquez, Ryan, Szeto, Gregory L., Barton, John P., Goel, Rishi Raj, Mangul, Serghei, Lubiana, Tiago, Gitter, Anthony, Greene, Casey S.

“…The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions of people with coronavirus…”
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Correction for Rando et al., "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure" by Rando, Halie M, MacLean, Adam L, Lee, Alexandra J, Lordan, Ronan, Ray, Sandipan, Bansal, Vikas, Skelly, Ashwin N, Sell, Elizabeth, Dziak, John J, Shinholster, Lamonica, D'Agostino McGowan, Lucy, Ben Guebila, Marouen, Wellhausen, Nils, Knyazev, Sergey, Boca, Simina M, Capone, Stephen, Qi, Yanjun, Park, YoSon, Mai, David, Sun, Yuchen, Boerckel, Joel D, Brueffer, Christian, Byrd, James Brian, Kamil, Jeremy P, Wang, Jinhui, Velazquez, Ryan, Szeto, Gregory L, Barton, John P, Goel, Rishi Raj, Mangul, Serghei, Lubiana, Tiago, Gitter, Anthony, Greene, Casey S

“…In the 2nd paragraph of Acknowledgements, “S.M.B. is currently an employee at AstraZeneca, Gaithersburg, MD, USA, and may own stock or stock options; work was…”
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Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance by Wellhausen, Nils, Baek, Joanne, Gill, Saar I., June, Carl H.

“…Adoptive cell therapies engineered to express chimeric antigen receptors (CARs) or transgenic T cell receptors (TCRs) to recognize and eliminate cancer cells…”
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An NK-like CAR T cell transition in CAR T cell dysfunction by Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

“…Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in…”
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Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy by Wellhausen, Nils, O'Connell, Ryan P, Lesch, Stefanie, Engel, Nils W, Rennels, Austin K, Gonzales, Donna, Herbst, Friederike, Young, Regina M, Garcia, K Christopher, Weiner, David, June, Carl H, Gill, Saar I

“…In the absence of cell surface cancer-specific antigens, immunotherapies such as chimeric antigen receptor (CAR) T cells, monoclonal antibodies, or bispecific…”
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Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy by Wellhausen, Nils, Agarwal, Sangya, Rommel, Philipp C, Gill, Saar I, June, Carl H

“…•Gene editing using CRIPSR/Cas has the potential to increase anti-tumor efficacy and persistence of adoptively transferred cells.•Allogeneic T cells can be…”
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Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures by Dagher, Oula, King, Tiffany R., Wellhausen, Nils, Posey, Avery D.

“…CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine,…”
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Epitope Editing in Hematopoietic Cells Enables CD45-Directed Immune Therapy by Wellhausen, Nils, Rennels, Austin K, Lesch, Stefanie, Agarwal, Sangya, Charria, Brooke, Choi, Grace, Young, Regina M, Garcia, Christopher, June, Carl H, Gill, Saar

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Production of Human CRISPR-Engineered CAR-T Cells by Agarwal, Sangya, Wellhausen, Nils, Levine, Bruce L, June, Carl H

“…Adoptive cell therapies using chimeric antigen receptor T cells (CAR-T cells) have demonstrated remarkable clinical efficacy in patients with hematological…”
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Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α by Roselle, Christopher, Horikawa, Izumi, Chen, Linhui, Kelly, Andre R, Gonzales, Donna, Da, Tong, Wellhausen, Nils, Rommel, Philipp C, Baker, Daniel, Suhoski, Megan, Scholler, John, O'Connor, Roddy S, Young, Regina M, Harris, Curtis C, June, Carl H

“…Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic…”
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Abstract 60: Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment by Good, Charly R., Kuramitsu, Shunichiro, Samareh, Parisa, Donahue, Greg, Ishiyama, Kenichi, Ma, Yujie, Wellhausen, Nils, Tian, Lifeng, Agarwal, Sangya, Guedan, Sonia, Aznar, M. Angela, Alexander, Katherine A., Zhang, Zhen, Singh, Nathan, Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O'Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

“…Abstract Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains largely ineffective in solid…”
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Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors by Chang, Ju-Fang, Wellhausen, Nils, Engel, Nils W, Landmann, Jack H, Hopkins, Caitlin R, Salas-McKee, January, Bear, Adham S, Selli, Mehmet E, Agarwal, Sangya, Jadlowsky, Julie K, Linette, Gerald P, Gill, Saar, June, Carl H, Fraietta, Joseph A, Singh, Nathan

“…Genome editing technologies have seen remarkable progress in recent years, enabling precise regulation of exogenous and endogenous genes. These advances have…”
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Abstract 3579: T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade by Muroyama, Yuki, Manne, Sasikanth, Oldridge, Derek A., Wellhausen, Nils, Greenplate, Allison R., Chilukuri, Lakshmi, Mathew, Divij, Xu, Caiyue, Herati, Ramin S., Huang, Alexander C., Zamarin, Dmitriy, Friedman, Claire F., Wherry, E. John

“…Abstract Despite the high tumor mutational burden (TMB), immune check point blockade (ICB) still fails in about half of microsatellite instability-high (MSI-H)…”
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Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure by Rando, Halie M, MacLean, Adam L, Lee, Alexandra J, Lordan, Ronan, Ray, Sandipan, Bansal, Vikas, Skelly, Ashwin N, Sell, Elizabeth, Dziak, John J, Shinholster, Lamonica, D'Agostino McGowan, Lucy, Ben Guebila, Marouen, Wellhausen, Nils, Knyazev, Sergey, Boca, Simina M, Capone, Stephen, Qi, Yanjun, Park, YoSon, Mai, David, Sun, Yuchen, Boerckel, Joel D, Brueffer, Christian, Byrd, James Brian, Kamil, Jeremy P, Wang, Jinhui, Velazquez, Ryan, Szeto, Gregory L, Barton, John P, Goel, Rishi Raj, Mangul, Serghei, Lubiana, Tiago, Gitter, Anthony, Greene, Casey S

“…The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions of people with coronavirus…”
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Abstract 3602: Mechanisms of CAR T cell dysfunction and identification of transcription factors that drive the exhaustion phenotype by Aznar, M. Angela, Good, Charly R., Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

“…Abstract Chimeric antigen receptor (CAR) T cell immunotherapy is FDA approved for the treatment of a subset of B cell malignancies but has shown limited…”
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